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ONTOLOGY REPORT - ANNOTATIONS

Term:retromer complex
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Accession:GO:0030904 term browser browse the term
Definition:A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35.


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retromer complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankfy1 ankyrin repeat and FYVE domain containing 1 located_in ISO (PMID:22284051) RGD PMID:22284051 NCBI chr10:57,312,246...57,383,964
Ensembl chr10:57,312,246...57,383,964 		JBrowse link
G Dctn1 dynactin subunit 1 part_of
located_in		 IEA
ISO		 GO_REF:0000107
(PMID:19619496)		 Ensembl
RGD		 PMID:19619496 GO_REF:0000107 NCBI chr 4:115,671,024...115,703,824
Ensembl chr 4:115,661,638...115,703,815 		JBrowse link
G Dennd4c DENN domain containing 4C part_of ISO (PMID:22472443) RGD PMID:22472443 NCBI chr 5:101,272,298...101,369,529
Ensembl chr 5:101,272,005...101,368,118 		JBrowse link
G Dennd5a DENN domain containing 5A located_in ISO (PMID:19619496) RGD PMID:19619496 NCBI chr 1:163,928,183...163,994,207
Ensembl chr 1:163,928,183...163,994,316 		JBrowse link
G Entr1 endosome associated trafficking regulator 1 located_in ISO (PMID:25278552) RGD PMID:25278552 NCBI chr 3:9,200,967...9,207,688
Ensembl chr 3:9,200,967...9,207,688 		JBrowse link
G Magel2 MAGE family member L2 located_in ISO (PMID:23452853) RGD PMID:23452853 NCBI chr 1:115,880,142...115,884,684
Ensembl chr 1:115,880,474...115,884,250 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family located_in ISO (PMID:19531583), (PMID:24344282) RGD PMID:19531583 PMID:24344282 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Snx1 sorting nexin 1 part_of ISO (PMID:19619496) RGD PMID:19619496 NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360 		JBrowse link
G Snx12 sorting nexin 12 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:66,226,995...66,356,945
Ensembl chr  X:66,227,053...66,356,950 		JBrowse link
G Snx2 sorting nexin 2 part_of ISO (PMID:11102511), (PMID:19619496) RGD PMID:11102511 PMID:19619496 NCBI chr18:46,602,223...46,643,870
Ensembl chr18:46,602,284...46,643,865 		JBrowse link
G Snx27 sorting nexin 27 part_of
located_in		 IEA
ISO
ISS		 GO_REF:0000107
(PMID:23563491)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:23563491 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:182,135,904...182,218,906
Ensembl chr 2:182,135,905...182,218,906 		JBrowse link
G Snx3 sorting nexin 3 located_in
part_of		 ISO
IBA		 (PMID:21725319), (PMID:24344282)
GO_REF:0000033		 RGD
GO_Central		 PMID:21725319 PMID:24344282 GO_REF:0000033 NCBI chr20:45,992,446...46,025,361
Ensembl chr20:45,992,720...46,025,379 		JBrowse link
G Snx5 sorting nexin 5 part_of ISO
ISS		 (PMID:19619496)
GO_REF:0000024		 RGD
UniProt		 PMID:19619496 GO_REF:0000024 NCBI chr 3:131,621,875...131,641,127
Ensembl chr 3:131,621,880...131,641,192 		JBrowse link
G Snx6 sorting nexin 6 part_of ISO (PMID:19619496) RGD PMID:19619496 NCBI chr 6:72,230,950...72,274,157
Ensembl chr 6:72,229,870...72,315,911 		JBrowse link
G Snx8 sorting nexin 8 located_in ISO (PMID:19782049) RGD PMID:19782049 NCBI chr12:14,251,829...14,300,435
Ensembl chr12:14,251,859...14,300,432 		JBrowse link
G Tbc1d5 TBC1 domain family, member 5 part_of ISO (PMID:20923837) RGD PMID:20923837 NCBI chr 9:3,503,328...4,017,131
Ensembl chr 9:3,513,623...4,016,913 		JBrowse link
G Trim27 tripartite motif-containing 27 located_in ISO (PMID:23452853) RGD PMID:23452853 NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643 		JBrowse link
G Vps26a VPS26 retromer complex component A part_of ISO
IDA		 (PMID:11102511), (PMID:28892079)
(MGI:4867115|PMID:21040701)		 RGD PMID:11102511 PMID:21040701 PMID:28892079 PMID:11102511 MGI:4867115, RGD:10412293 NCBI chr20:30,404,320...30,434,266
Ensembl chr20:30,404,325...30,434,131 		JBrowse link
G Vps26b VPS26 retromer complex component B part_of ISO (MGI:4867115|PMID:21040701) RGD PMID:21040701 MGI:4867115 NCBI chr 8:25,415,877...25,436,985
Ensembl chr 8:25,415,261...25,436,985 		JBrowse link
G Vps29 VPS29 retromer complex component part_of ISO
IBA
IEA
ISS		 (PMID:11102511), (PMID:28892079)
GO_REF:0000033
GO_REF:0000002
(MGI:4867115|PMID:21040701)
GO_REF:0000024		 RGD
GO_Central
InterPro
UniProt		 PMID:11102511 PMID:21040701 PMID:28892079 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 MGI:4867115 NCBI chr12:34,208,911...34,217,977
Ensembl chr12:34,207,263...34,217,964 		JBrowse link
G Vps35 VPS35 retromer complex component part_of IDA
IBA
ISO		 PMID:11102511
GO_REF:0000033
(MGI:4867115|PMID:21040701)
(PMID:11102511), (PMID:28892079)		 GO_Central
RGD		 PMID:11102511 PMID:21040701 PMID:28892079 PMID:11102511 GO_REF:0000033 MGI:4867115, RGD:10412293 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
retromer, cargo-selective complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vps26a VPS26 retromer complex component A part_of ISO
IEA		 (PMID:27385586)
GO_REF:0000107		 RGD
Ensembl		 PMID:27385586 GO_REF:0000107 NCBI chr20:30,404,320...30,434,266
Ensembl chr20:30,404,325...30,434,131 		JBrowse link
G Vps29 VPS29 retromer complex component part_of ISO
IEA		 (PMID:27385586)
GO_REF:0000107		 RGD
Ensembl		 PMID:27385586 GO_REF:0000107 NCBI chr12:34,208,911...34,217,977
Ensembl chr12:34,207,263...34,217,964 		JBrowse link
G Vps35 VPS35 retromer complex component part_of ISO (PMID:20164305), (PMID:27385586) RGD PMID:20164305 PMID:27385586 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
retromer, tubulation complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102549158 sorting nexin-1-like part_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr11:27,412,769...27,414,504
Ensembl chr11:27,413,195...27,414,109 		JBrowse link
G Snx1 sorting nexin 1 part_of ISO
IEA		 UniProtKB:O60749 (PMID:11102511)
GO_REF:0000107		 RGD
Ensembl		 PMID:11102511 GO_REF:0000107 NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360 		JBrowse link
G Snx2 sorting nexin 2 part_of ISO UniProtKB:Q13596 (PMID:11102511) RGD PMID:11102511 NCBI chr18:46,602,223...46,643,870
Ensembl chr18:46,602,284...46,643,865 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20624
    cellular anatomical entity 20386
      endomembrane system 4271
        retromer complex 22
          retromer, cargo-selective complex 3
          retromer, tubulation complex 3
Path 2
Term Annotations click to browse term
  cellular_component 20624
    cellular anatomical entity 20386
      membrane 10274
        membrane protein complex 1383
          retromer complex 22
            retromer, cargo-selective complex 3
            retromer, tubulation complex 3
paths to the root