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Gene: Dennd5a (DENN domain containing 5A) Rattus norvegicus

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Symbol:

Dennd5a

Name:

DENN domain containing 5A

RGD ID:

1306759

Description:

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in negative regulation of neuron projection development. Predicted to be located in Golgi apparatus. Predicted to be part of retromer complex. Predicted to be active in trans-Golgi network. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 49. Orthologous to human DENND5A (DENN domain containing 5A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

DENN domain-containing protein 5A; DENN/MADD domain containing 5A; LOC308942; Rab6 interacting protein 1; Rab6ip1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DENND5A (DENN domain containing 5A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dennd5a (DENN domain containing 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dennd5a (DENN domain containing 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DENND5A (DENN domain containing 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DENND5A (DENN domain containing 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dennd5a (DENN domain containing 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DENND5A (DENN domain containing 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DENND5A (DENN domain containing 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dennd5a (DENN domain containing 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DENND5B (DENN domain containing 5B)	HGNC	OrthoDB
Homo sapiens (human):	RAB11FIP4 (RAB11 family interacting protein 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DENND5A (DENN domain containing 5A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dennd5a (DENN domain containing 5A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dennd5a (DENN/MADD domain containing 5A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lst-6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	pns	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dennd5a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	173,362,959 - 173,428,973 (-)	NCBI		GRCr8
mRatBN7.2	1	163,928,183 - 163,994,207 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	163,928,183 - 163,994,316 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	172,264,337 - 172,330,037 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	179,450,376 - 179,516,076 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	172,132,559 - 172,198,224 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	174,524,047 - 174,588,553 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	174,524,047 - 174,588,529 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	181,508,456 - 181,572,964 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	167,519,644 - 167,586,964 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	167,630,306 - 167,697,627 (-)	NCBI
Celera	1	161,826,111 - 161,891,772 (-)	NCBI		Celera
Cytogenetic Map	1	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd5a	Rat	developmental and epileptic encephalopathy 49		ISO	DENND5A (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:16199547 more ...
Dennd5a	Rat	genetic disease		ISO	DENND5A (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd5a	Rat	developmental and epileptic encephalopathy 49		ISO	DENND5A (Homo sapiens)	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd5a	Rat	(-)-demecolcine	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Demecolcine results in increased expression of DENND5A mRNA	CTD	PMID:23649840
Dennd5a	Rat	1,2-dimethylhydrazine	increases expression	ISO	Dennd5a (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in increased expression of DENND5A mRNA	CTD	PMID:22206623
Dennd5a	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	Dennd5a (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of DENND5A mRNA	CTD	PMID:22206623
Dennd5a	Rat	17beta-estradiol	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Estradiol results in increased expression of DENND5A mRNA	CTD	PMID:20106945
Dennd5a	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Dennd5a (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of DENND5A mRNA	CTD	PMID:21570461
Dennd5a	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases phosphorylation	EXP		6480464	Tetrachlorodibenzodioxin results in increased phosphorylation of DENND5A protein	CTD	PMID:23298284
Dennd5a	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of DENND5A mRNA	CTD	PMID:24780913
Dennd5a	Rat	acetylsalicylic acid	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Aspirin results in increased expression of DENND5A mRNA	CTD	PMID:11906190
Dennd5a	Rat	aflatoxin B1	decreases methylation	ISO	DENND5A (Homo sapiens)	6480464	Aflatoxin B1 results in decreased methylation of DENND5A intron	CTD	PMID:30157460
Dennd5a	Rat	Aflatoxin B2 alpha	decreases methylation	ISO	DENND5A (Homo sapiens)	6480464	aflatoxin B2 results in decreased methylation of DENND5A intron	CTD	PMID:30157460
Dennd5a	Rat	all-trans-retinoic acid	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Tretinoin results in increased expression of DENND5A mRNA	CTD	PMID:33167477
Dennd5a	Rat	Aroclor 1254	decreases expression	ISO	Dennd5a (Mus musculus)	6480464	Chlorodiphenyl (54% Chlorine) results in decreased expression of DENND5A mRNA	CTD	PMID:23650126
Dennd5a	Rat	arsane	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of DENND5A mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DENND5A mRNA	CTD	PMID:39836092
Dennd5a	Rat	arsenic atom	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of DENND5A mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DENND5A mRNA	CTD	PMID:39836092
Dennd5a	Rat	arsenite(3-)	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	arsenite inhibits the reaction [G3BP1 protein binds to DENND5A mRNA]	CTD	PMID:32406909
Dennd5a	Rat	benzene	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Benzene results in increased expression of DENND5A mRNA	CTD	PMID:20359517
Dennd5a	Rat	benzo[a]pyrene	increases methylation	ISO	DENND5A (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of DENND5A promoter	CTD	PMID:27901495
Dennd5a	Rat	benzo[a]pyrene	decreases methylation	ISO	DENND5A (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of DENND5A 3' UTR	CTD	PMID:27901495
Dennd5a	Rat	benzoates	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Benzoates analog results in increased expression of DENND5A mRNA	CTD	PMID:29472718
Dennd5a	Rat	beta-lapachone	decreases expression	ISO	DENND5A (Homo sapiens)	6480464	beta-lapachone results in decreased expression of DENND5A mRNA	CTD	PMID:38218311
Dennd5a	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of DENND5A mRNA	CTD	PMID:25181051
Dennd5a	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of DENND5A mRNA	CTD	PMID:30816183 and PMID:34947998
Dennd5a	Rat	cadmium atom	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DENND5A mRNA	CTD	PMID:35301059
Dennd5a	Rat	cadmium dichloride	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Cadmium Chloride results in increased expression of DENND5A mRNA	CTD	PMID:38568856
Dennd5a	Rat	cadmium dichloride	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DENND5A mRNA	CTD	PMID:35301059
Dennd5a	Rat	CGP 52608	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	CGP 52608 promotes the reaction [RORA protein binds to DENND5A gene]	CTD	PMID:28238834
Dennd5a	Rat	cisplatin	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Cisplatin results in increased expression of DENND5A mRNA	CTD	PMID:27594783
Dennd5a	Rat	cobalt dichloride	increases expression	ISO	DENND5A (Homo sapiens)	6480464	cobaltous chloride results in increased expression of DENND5A mRNA	CTD	PMID:19320972 and PMID:19376846
Dennd5a	Rat	copper(II) sulfate	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Copper Sulfate results in increased expression of DENND5A mRNA	CTD	PMID:19549813
Dennd5a	Rat	crocidolite asbestos	affects expression	ISO	DENND5A (Homo sapiens)	6480464	Asbestos and Crocidolite affects the expression of DENND5A mRNA	CTD	PMID:24160326
Dennd5a	Rat	cyclosporin A	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Cyclosporine results in increased expression of DENND5A mRNA	CTD	PMID:20106945 and PMID:25562108
Dennd5a	Rat	Dibutyl phosphate	affects expression	ISO	DENND5A (Homo sapiens)	6480464	di-n-butylphosphoric acid affects the expression of DENND5A mRNA	CTD	PMID:37042841
Dennd5a	Rat	dichloromethane	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Methylene Chloride results in increased expression of DENND5A mRNA	CTD	PMID:20359517
Dennd5a	Rat	dorsomorphin	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DENND5A mRNA	CTD	PMID:27188386
Dennd5a	Rat	doxorubicin	decreases expression	ISO	DENND5A (Homo sapiens)	6480464	Doxorubicin results in decreased expression of DENND5A mRNA	CTD	PMID:29803840
Dennd5a	Rat	ethanol	affects splicing	ISO	Dennd5a (Mus musculus)	6480464	Ethanol affects the splicing of DENND5A mRNA	CTD	PMID:30319688
Dennd5a	Rat	ethanol	increases expression	ISO	Dennd5a (Mus musculus)	6480464	Ethanol results in increased expression of DENND5A mRNA	CTD	PMID:30319688
Dennd5a	Rat	ethylbenzene	increases expression	ISO	DENND5A (Homo sapiens)	6480464	ethylbenzene results in increased expression of DENND5A mRNA	CTD	PMID:20359517
Dennd5a	Rat	folic acid	multiple interactions	ISO	Dennd5a (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of DENND5A mRNA	CTD	PMID:22206623
Dennd5a	Rat	formaldehyde	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Formaldehyde results in increased expression of DENND5A mRNA	CTD	PMID:23649840
Dennd5a	Rat	FR900359	increases phosphorylation	ISO	DENND5A (Homo sapiens)	6480464	FR900359 results in increased phosphorylation of DENND5A protein	CTD	PMID:37730182
Dennd5a	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of DENND5A mRNA	CTD	PMID:22061828
Dennd5a	Rat	gentamycin	increases expression	EXP		6480464	Gentamicins results in increased expression of DENND5A mRNA	CTD	PMID:33387578
Dennd5a	Rat	isotretinoin	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Isotretinoin results in increased expression of DENND5A mRNA	CTD	PMID:20436886
Dennd5a	Rat	lead(0)	affects splicing	ISO	DENND5A (Homo sapiens)	6480464	Lead affects the splicing of DENND5A mRNA	CTD	PMID:28903495
Dennd5a	Rat	leflunomide	increases expression	ISO	DENND5A (Homo sapiens)	6480464	leflunomide results in increased expression of DENND5A mRNA	CTD	PMID:28988120
Dennd5a	Rat	lipopolysaccharide	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of DENND5A mRNA	CTD	PMID:35811015
Dennd5a	Rat	lipopolysaccharide	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Lipopolysaccharides results in increased expression of DENND5A mRNA	CTD	PMID:35811015
Dennd5a	Rat	manganese atom	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of DENND5A mRNA and [manganese chloride results in increased abundance of Manganese] which results in decreased expression of DENND5A mRNA	CTD	PMID:39836092
Dennd5a	Rat	manganese(0)	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of DENND5A mRNA and [manganese chloride results in increased abundance of Manganese] which results in decreased expression of DENND5A mRNA	CTD	PMID:39836092
Dennd5a	Rat	manganese(II) chloride	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of DENND5A mRNA and [manganese chloride results in increased abundance of Manganese] which results in decreased expression of DENND5A mRNA	CTD	PMID:39836092
Dennd5a	Rat	methamphetamine	increases expression	ISO	Dennd5a (Mus musculus)	6480464	Methamphetamine results in increased expression of DENND5A mRNA	CTD	PMID:26307267
Dennd5a	Rat	o-xylene	increases expression	ISO	DENND5A (Homo sapiens)	6480464	2-xylene results in increased expression of DENND5A mRNA	CTD	PMID:20359517
Dennd5a	Rat	ozone	multiple interactions	ISO	Dennd5a (Mus musculus)	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of DENND5A mRNA	CTD	PMID:34911549
Dennd5a	Rat	ozone	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[Air Pollutants results in increased abundance of Ozone] which affects the expression of DENND5A mRNA	CTD	PMID:35430440
Dennd5a	Rat	paracetamol	affects expression	ISO	Dennd5a (Mus musculus)	6480464	Acetaminophen affects the expression of DENND5A mRNA	CTD	PMID:17562736
Dennd5a	Rat	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of DENND5A mRNA	CTD	PMID:35811015
Dennd5a	Rat	SB 431542	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DENND5A mRNA	CTD	PMID:27188386
Dennd5a	Rat	serpentine asbestos	affects expression	ISO	DENND5A (Homo sapiens)	6480464	Asbestos and Serpentine affects the expression of DENND5A mRNA	CTD	PMID:24160326
Dennd5a	Rat	silver atom	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Silver results in increased expression of DENND5A mRNA	CTD	PMID:26014281
Dennd5a	Rat	silver(0)	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Silver results in increased expression of DENND5A mRNA	CTD	PMID:26014281
Dennd5a	Rat	sodium arsenite	increases expression	ISO	DENND5A (Homo sapiens)	6480464	sodium arsenite results in increased expression of DENND5A mRNA	CTD	PMID:38568856
Dennd5a	Rat	sodium arsenite	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of DENND5A mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DENND5A mRNA	CTD	PMID:39836092
Dennd5a	Rat	sunitinib	decreases expression	ISO	DENND5A (Homo sapiens)	6480464	Sunitinib results in decreased expression of DENND5A mRNA	CTD	PMID:31533062
Dennd5a	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of DENND5A mRNA	CTD	PMID:34492290
Dennd5a	Rat	thiram	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Thiram results in increased expression of DENND5A mRNA	CTD	PMID:38568856
Dennd5a	Rat	titanium dioxide	increases methylation	ISO	Dennd5a (Mus musculus)	6480464	titanium dioxide results in increased methylation of DENND5A gene	CTD	PMID:35295148
Dennd5a	Rat	toluene	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Toluene results in increased expression of DENND5A mRNA	CTD	PMID:20359517
Dennd5a	Rat	trichloroethene	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Trichloroethylene results in increased expression of DENND5A mRNA	CTD	PMID:20359517
Dennd5a	Rat	trichloroethene	increases methylation	EXP		6480464	Trichloroethylene results in increased methylation of DENND5A gene	CTD	PMID:27618143
Dennd5a	Rat	triphenyl phosphate	affects expression	ISO	DENND5A (Homo sapiens)	6480464	triphenyl phosphate affects the expression of DENND5A mRNA	CTD	PMID:37042841
Dennd5a	Rat	valproic acid	affects expression	ISO	Dennd5a (Mus musculus)	6480464	Valproic Acid affects the expression of DENND5A mRNA	CTD	PMID:17963808
Dennd5a	Rat	valproic acid	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DENND5A mRNA	CTD	PMID:27188386
Dennd5a	Rat	vincristine	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Vincristine results in increased expression of DENND5A mRNA	CTD	PMID:23649840
Dennd5a	Rat	vitamin E	increases expression	ISO	DENND5A (Homo sapiens)	6480464	Vitamin E results in increased expression of DENND5A mRNA	CTD	PMID:19244175
Dennd5a	Rat	zinc atom	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[PCI 5002 co-treated with Zinc] results in increased expression of DENND5A mRNA	CTD	PMID:18593933
Dennd5a	Rat	zinc(0)	multiple interactions	ISO	DENND5A (Homo sapiens)	6480464	[PCI 5002 co-treated with Zinc] results in increased expression of DENND5A mRNA	CTD	PMID:18593933

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd5a	Rat	negative regulation of neuron projection development	involved_in	IMP		12859078	PMID:27866705	UniProt
Dennd5a	Rat	retrograde transport, endosome to Golgi	involved_in	ISO	DENND5A (Homo sapiens)	1624291	PMID:19619496	RGD	PMID:19619496
Dennd5a	Rat	retrograde transport, endosome to Golgi	involved_in	IEA	UniProtKB:Q6IQ26 and ensembl:ENSP00000328524	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dennd5a	Rat	retrograde transport, endosome to Golgi	involved_in	IBA	PANTHER:PTN002918134 and UniProtKB:Q6IQ26	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd5a	Rat	cytosol	located_in	IEA	GO:0042147	1600115	GO_REF:0000108	GOC	GO_REF:0000108
Dennd5a	Rat	Golgi apparatus	located_in	ISO	Dennd5a (Mus musculus)	1624291	PMID:19141279	RGD	PMID:19141279
Dennd5a	Rat	Golgi apparatus	located_in	IEA	UniProtKB:Q6PAL8 and ensembl:ENSMUSP00000079295	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dennd5a	Rat	Golgi apparatus	located_in	IEA	UniProtKB-KW:KW-0333	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Dennd5a	Rat	Golgi membrane	located_in	IEA	UniProtKB-SubCell:SL-0134	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Dennd5a	Rat	membrane	located_in	IEA	UniProtKB-SubCell:SL-0162	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Dennd5a	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Dennd5a	Rat	retromer complex	located_in	ISO	DENND5A (Homo sapiens)	1624291	PMID:19619496	RGD	PMID:19619496
Dennd5a	Rat	retromer complex	located_in	IEA	UniProtKB:Q6IQ26 and ensembl:ENSP00000328524	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dennd5a	Rat	trans-Golgi network	located_in	ISO	DENND5A (Homo sapiens)	1624291	PMID:19619496	RGD	PMID:19619496
Dennd5a	Rat	trans-Golgi network	located_in	IEA	UniProtKB:Q6IQ26 and ensembl:ENSP00000328524	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dennd5a	Rat	trans-Golgi network	is_active_in	IBA	PANTHER:PTN002918134 and UniProtKB:Q6IQ26	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd5a	Rat	guanyl-nucleotide exchange factor activity	enables	IEA	UniProtKB-KW:KW-0344	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Dennd5a	Rat	guanyl-nucleotide exchange factor activity	enables	IEA	UniProtKB:Q6IQ26 and ensembl:ENSP00000328524	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dennd5a	Rat	guanyl-nucleotide exchange factor activity	enables	IEA	InterPro:IPR047278	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Dennd5a	Rat	guanyl-nucleotide exchange factor activity	enables	IBA	PANTHER:PTN001329172 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Dennd5a	Rat	guanyl-nucleotide exchange factor activity	enables	ISO	DENND5A (Homo sapiens)	1624291	PMID:20937701	RGD	PMID:20937701
Dennd5a	Rat	protein binding	enables	ISO	DENND5A (Homo sapiens)	1624291	UniProtKB:A6NEM1 and PMID:32296183	RGD	PMID:32296183
Dennd5a	Rat	protein binding	enables	ISO	Dennd5a (Mus musculus)	1624291	UniProtKB:P20340 more ...	RGD	PMID:19141279
Dennd5a	Rat	small GTPase binding	enables	IEA	InterPro:IPR047278	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Dennd5a	Rat	small GTPase binding	enables	IEA	UniProtKB:Q6PAL8 and ensembl:ENSMUSP00000079295	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dennd5a	Rat	small GTPase binding	enables	ISO	Dennd5a (Mus musculus)	1624291	PMID:7631419	RGD	PMID:7631419
Dennd5a	Rat	small GTPase binding	enables	IBA	MGI:1201681 and PANTHER:PTN001329172	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Epileptic Encephalopathy Caused by Mutations in the Guanine Nucleotide Exchange Factor DENND5A.	Han C, etal., Am J Hum Genet. 2016 Dec 1;99(6):1359-1367. doi: 10.1016/j.ajhg.2016.10.006. Epub 2016 Nov 17.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:7631419	PMID:12477932	PMID:19141279	PMID:19619496	PMID:20937701	PMID:25931508

Dennd5a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	173,362,959 - 173,428,973 (-)	NCBI		GRCr8
mRatBN7.2	1	163,928,183 - 163,994,207 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	163,928,183 - 163,994,316 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	172,264,337 - 172,330,037 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	179,450,376 - 179,516,076 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	172,132,559 - 172,198,224 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	174,524,047 - 174,588,553 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	174,524,047 - 174,588,529 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	181,508,456 - 181,572,964 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	167,519,644 - 167,586,964 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	167,630,306 - 167,697,627 (-)	NCBI
Celera	1	161,826,111 - 161,891,772 (-)	NCBI		Celera
Cytogenetic Map	1	q33	NCBI

DENND5A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	9,138,825 - 9,265,350 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	9,138,825 - 9,265,959 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	9,160,372 - 9,286,897 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	9,116,948 - 9,243,447 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	9,116,952 - 9,243,447	NCBI
Celera	11	9,282,225 - 9,408,081 (-)	NCBI		Celera
Cytogenetic Map	11	p15.4	NCBI
HuRef	11	8,832,931 - 8,959,599 (-)	NCBI		HuRef
CHM1_1	11	9,159,270 - 9,285,849 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	9,223,596 - 9,350,195 (-)	NCBI		T2T-CHM13v2.0

Dennd5a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	109,492,987 - 109,559,677 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	109,492,987 - 109,559,677 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	109,893,780 - 109,960,470 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	109,893,780 - 109,960,470 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	117,037,294 - 117,103,936 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	109,684,957 - 109,751,599 (-)	NCBI		MGSCv36	mm8
Celera	7	109,867,849 - 109,934,440 (-)	NCBI		Celera
Cytogenetic Map	7	E3	NCBI
cM Map	7	57.62	NCBI

Dennd5a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	24,861,242 - 24,955,045 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	24,861,950 - 24,955,031 (-)	NCBI	ChiLan1.0	ChiLan1.0

DENND5A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	11,573,343 - 11,702,036 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	11,531,664 - 11,660,173 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	9,267,037 - 9,395,677 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	9,006,846 - 9,075,378 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	9,006,855 - 9,077,241 (-)	Ensembl	panpan1.1		panPan2

DENND5A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	32,465,278 - 32,573,381 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	32,370,913 - 32,574,588 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	32,033,154 - 32,141,431 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	33,338,799 - 33,447,008 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	33,338,813 - 33,447,007 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	32,607,530 - 32,716,001 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	32,773,710 - 32,882,228 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	33,067,632 - 33,176,152 (-)	NCBI		UU_Cfam_GSD_1.0

Dennd5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	52,826,751 - 52,914,868 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936528	8,860,143 - 8,947,975 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936528	8,860,731 - 8,948,848 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DENND5A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	268,211 - 357,324 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	268,372 - 357,334 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	363,773 - 426,216 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DENND5A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	55,545,901 - 55,673,513 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	153,233,146 - 153,361,708 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dennd5a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	1,279,086 - 1,382,097 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	1,279,200 - 1,382,091 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Dennd5a
271 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	302
Count of miRNA genes:	188
Interacting mature miRNAs:	215
Transcripts:	ENSRNOT00000017485
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	121767634	166767634	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	115585465	172949803	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	117917486	196963478	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	158633083	203633083	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121833674	166833674	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	126540680	171540680	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
634315	Niddm45	Non-insulin dependent diabetes mellitus QTL 45	7.16		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	144267916	172949660	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
61379	Bp44	Blood pressure QTL 44	19.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144267916	174133260	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	118944747	163944747	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	136830018	181830018	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1582204	Livw1	Liver weight QTL 1	3.6	0.0003	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	1	155422851	172949803	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	168883176	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
8693608	Alc24	Alcohol consumption QTL 24	2.3	0.74	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	150452391	168228760	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	156677124	201278233	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
152025212	Bw190	Body weight QTL 190	5.7		body mass (VT:0001259)		1	123556856	196963478	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
631548	Bp88	Blood pressure QTL 88	5	0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	156677124	176484451	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat

RH141891

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	163,967,717 - 163,967,897 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	174,562,090 - 174,562,269	NCBI	Rnor6.0
Rnor_5.0	1	181,546,499 - 181,546,678	UniSTS	Rnor5.0
RGSC_v3.4	1	167,560,525 - 167,560,704	UniSTS	RGSC3.4
Celera	1	161,865,580 - 161,865,759	UniSTS
RH 3.4 Map	1	1348.2	UniSTS
Cytogenetic Map	1	q33	UniSTS

AA819350

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	163,928,201 - 163,928,393 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	174,524,066 - 174,524,257	NCBI	Rnor6.0
Rnor_5.0	1	181,508,475 - 181,508,666	UniSTS	Rnor5.0
RGSC_v3.4	1	167,519,663 - 167,519,854	UniSTS	RGSC3.4
Celera	1	161,826,130 - 161,826,321	UniSTS
RH 3.4 Map	1	1348.2	UniSTS
Cytogenetic Map	1	q33	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001107546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC098265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017485 ⟹ ENSRNOP00000017485

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	163,928,183 - 163,994,158 (-)	Ensembl
Rnor_6.0 Ensembl	1	174,524,047 - 174,588,529 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106309 ⟹ ENSRNOP00000096686

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	163,928,183 - 163,994,316 (-)	Ensembl

RefSeq Acc Id:

NM_001107546 ⟹ NP_001101016

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	173,362,959 - 173,428,926 (-)	NCBI
mRatBN7.2	1	163,928,183 - 163,994,158 (-)	NCBI
Rnor_6.0	1	174,524,047 - 174,588,529 (-)	NCBI
Rnor_5.0	1	181,508,456 - 181,572,964 (-)	NCBI
RGSC_v3.4	1	167,519,644 - 167,586,964 (-)	RGD
Celera	1	161,826,111 - 161,891,772 (-)	RGD

Sequence:

show sequence

CCGCCCTTCCTCTAGCTTGCTCCGGCTGCGGTGCTTAGGACAGCGTCCAGGATGCGGCGCGGGGTGGCCTGGCGCCCCCCTGCCCCAGCACGGCAGCGGCGGCCGCTAGGACCCGGCGAGGCCCGGGG
GCAGCGGCCGGAGCCTCGGTAGCGGCGGCGGAGGGAGCGGCGGCTGAGGGCGAGCGGGCGGCCGGGGGCGGGGGCTCGGCTCCGCGCGGCTCGCCCCGCTCGGCCCGGCGCCATGAGCGGCGGCGGCG
GCGGAGGGGGCTCGGCCCCCAGTCGCTTCGCCGACTATTTTGTCATCTGCGGGCTGGACACCGAGACCGGGTTGGAGCCGGACGAGCTGTCGGCATTATGCCAGTACATTCAGGCTTCTAAAGCCAGG
GATGGTGCCAGCCCTTTCATTTCAAGTACGACTGAAGGAGAAAATTTTGAGCAGACGCCATTGAGACGAACATTCAAGTCTAAGGTCCTTGCCCGATACCCTGAGAATGTAGACTGGAATCCGTTTGA
CCAGGATGCAGTGGGAATGCTGTGCATGCCCAAAGGGCTGGCATTCAAGACCCAGGCTGATCCCAGGGAGCCACAGTTCCATGCCTTTATTATCACAAGGGAGGATGGCTCTCGGACATTTGGGTTTG
CCCTTACCTTTTATGAAGAAGTTACCAGCAAGCAGATCTGCAGTGCAATGCAGACCCTCTACCACATGCACAACGCTGAGTATGATGTCCTTCATGCTCCACTTGCTGATGGTGGAGACCAGAGTGGC
ATGGAAGACGGTGAAGGCATTCCTGGGACCAAGCTGCAGCGCTTCAACTCCTATGACATTAGCAGGGACACACTCTATGTTTCTAAATGCATCTGTCTCATCACACCCATGTCTTTCATGAAGGCATG
TCGGAGTGTGCTGCAGCAGCTCCACCAGGCAGTCACGTCACCTCAGCCCCCTCCTCTGCCCCTCGAGAGCTACATATACAATGTACTCTATGAGGTGCCACTTCCACCTCCTGGCCGCTCCCTGAAGT
TTTCTGGGGTCTATGGGCCAATAATCTGCCAGAGACCAAGTACCAATGAGCTTCCTCTATTTGATTTCCCTGTCAAAGAGGTCTTTGAACTGCTTGGGGTGGAGAATGTGTTTCAGCTTTTTACTTGT
GCCCTTCTGGAGTTTCAAATACTGCTCTACTCACAGCATTACCAGAGACTGATGACCGTGGCGGAGACAATTACAGCTCTGATGTTTCCTTTCCAATGGCAGCATGTCTATGTCCCCATTCTCCCAGC
TTCTCTCCTGCATTTCTTAGACGCTCCTGTTCCGTACCTGATGGGGTTGCACTCCAACGGCTTGGATGACCGCTCAAAGTTGGAGCTGCCTCAGGAGGCTAACCTCTGCTTTGTGGATGTTGACAACC
ACTTCATTGAGTTGCCAGAGGACTTGCCTCAATTTCCTAACAAACTGGAGTTTGTCCAGGAGGTCTCTGAGATCCTCATGGCCTTCGGCGTTCCCCCTGAAGGGAACCTCCACTGCAGCGAAAGTGCT
TCGAAGCTGAAGAGGATCCGAGCCTCCGAGCTTGTGTCTGACAAGAAGAACGGGAACATTGCGGGCTCCCCTTTGCATTCCTATGAGCTCCTCAAGGAAAATGAAACGATCGCTCGGTTGCAAGCTTT
GGTCAAGAGGACTGGAGTGAGTTTGGAAAAACTGGAAGTTCGTGAAGATCCCAGTAGCAATAAAGATTTCAAAGTTCAGTGTGATGAAGAAGAACTCAGGATTTACCAGCTAAACATTCAGATCCGGG
AAGTTTTTGCCAATCGCTTTACCCAGATGTTTGCTGATTATGAAGTGTTTGTCATCCAGCCCAGCCAGGATAAGGAGTCCTGGCTCAGCAACAGGGAGCAGATGCAGAACTTTGATAAAGCGTCCTTT
CTGTCAGATCAGCCTGAGCCCTACCTGCCCTTCCTCTCAAGATTCCTAGAGACCCAGATGTTTGCATCTTTTATTGACAACAAGATCATGTGTCACGATGATGACGATAAAGACCCTGTCCTCCGGGT
CTTTGACTCAAGGGTAGACAAGATCAGACTGTTGAATGTTCGAACACCTACTCTTAGGACATCCATGTACCAGAAATGTACCACTGTGGATGAAGCAGAAAAAGCAATTGAGCTACGTCTGGCAAAAA
TTGACCACACTGCAGTTCACCCTCATCTTCTTGACATGAAAATTGGACAAGGAAAATATGAACCTGGCTTTTTCCCTAAGCTACAATCAGATGTACTTTGCACCGGGCCAGCCAGCAACAAGTGGACA
AAAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGACCGGCAGAAGCAGCACACGGAACACTTGCGCTTAGACAATGACCAGAGGGAGAAGTACATCCAGGAAGCCAGGAATATGGGCAGTACCATCCG
TCAGCCCAAACTGTCCAACCTGTCTCCCTCGGTCATTGCCCAGACCAACTGGAAGTTTGTAGAAGGCCTGCTGAAGGAATGCCGAAACAAGACCAAGAGGATGCTGGTAGAGAAGATGGGTCGAGAGG
CAGTGGAGCTGGGGCATGGGGAAGTGAACATCACCGGTGTGGAAGAGAATACTTTGATTGCCAGCCTCTGTGACCTTCTGGAAAGGATCTGGAGCCACGGGCTACAAGTAAAACAGGGGAAGTCAGCT
TTGTGGTCTCATTTGTTACATTATCAGGAAAACCGGCAGAGAAAACTCACATCAGGAAGCCTCAGTACCTCAGGAATACTTCTTGATTCAGAACGGAGAAAGTCTGACGCCAGTGCTGTCATGTCTCC
CCTGAGGGTCTCCTTAATCCAGGATATGAGGCACATTCAGAATATTGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAGAAGAAGCTACTCTCCAGACATCTGA
AGCAGCTTCTTTCAGACCATGAGCTCACCAAGAAGCTGTACAAGCGTTATGCCTTCCTGCGCTGCGATGACGAGAAGGAGCAGTTCCTCTATCACCTGCTCTCCTTCAACGCAGTGGACTACTTCTGC
TTCACCAATGTCTTCACAACCATCCTGATCCCATACCACATTTTGATTGTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACCGCCAATCCATGGATCTGTATATCAGGAGAACTGGGTGAAACACA
GATCCTGCAGATCCCCAGGAATGTGCTAGAGATGACTTTTGAGTGCCAGAACCTGGGGAAGCTCACAACTGTCCAGATTGGCCACGATAATTCTGGGCTGTATGCCAAATGGCTTGTGGAATATGTGA
TGGTCAGGAATGAGATCACAGGACATACCTACAAGTTTCCATGTGGCCGATGGCTGGGCAAGGGTATGGATGATGGAAGCCTGGAGCGTGTGCTTGTTGGGGAGCTGCTCACGTCCCTACCCGAGGTA
GACGAGAGGCCTTGTCGGACTCCACCACTGCAGCAGTCCCCCAGCGTCATCCGGAGACTTGTGACCATCTCACCCAACAATAAGCCCAAGCTGAACACAGGGCAGATCCAGGAATCCATCGGGGAGGC
GGTCAATGGCATTGTGAAGCACTTCCATAAACCTGAGAAAGAGCGTGGCAGTCTGACGCTGTTGCTTTGTGGAGAGTGTGGTCTCGTTTCAGCACTGGAGCAAGCTTTCCAGCATGGATTTAAATCAC
CCCGGCTCTTCAAAAATGTCTTCATTTGGGACTTCCTGGAGAAAGCACAAACCTATTATGAGACGTTAGAGCAGAATGATGTAGTCCCAGAGGAAAACTGGCACACACGGGCCCGCAACTTCTGCCGA
TTTGTCACCGCAGTCAACAACACGCCTCGGAACATCGGCAAGGACGGCAAATTTCAGATGCTGGTGTGCCTGGGAGCCAGAGATCACCTCCTGCACCACTGGATAGCCTTGCTGGCCGACTGTCCCAT
CACTGCACACATGTATGAGGATGTGGCACTGATCAAGGACCACACGCTCGTCAATTCTTTGATCCGAGTGCTGCAGACCCTGCAAGAATTCAACATCACACTGGACACCTCCCTTGTGAAGGGCATTG
ACATCTGAGCTCCCGGCCCCAGCCAGCAGCAAGACCCAGGAGGACGCCCCACAGCTCGGCCTCCTCATCCCAGAGGGACCCAAGCAGGCCGTGAGGGACAGAGAGGATGTGTATACTCACTGTAAAAA
GAAAACTAGAGGATTTTTGGAAAAAATAATCTATTTTAGAGTTTATTTGCTTCCTGCTTTTTACACACTTTCATGTGAGAGAGACAGGAGAGGGCGAGGCTGGTGCTGCTTGTTTTGAAGCTGGTGCC
TCCCTTGCACGGCCGCACGCTGGGAGCCTGTGGCCTCCCAGGCTGAGCCTGCACACACGTCACATCGATGAGGCCATTCCACATCGTTTTTAACTAATGTTTTCTATATTAACATTATTCTGGCTCTC
TGGCTTTCACGGGCCATGCACAGGTGTGCGAGTGGGAGATCCCATGCTCAAAGGGATTTTTAGCAGTGCCTGTGATCAAGCACTGCGGAGTCAGCCCCACATCCGTTTCCCCCTTCCCCTTTTTTGTC
AGTATTATTTGGGAAGGAGATATGCCAGGACAATGTCATCGTGCTACCGTCATGCAGAAAATCATGTTTCCTGTTGGCACAACGTTGCGCAGAAGTAAACATGAGCATGTTGTAACCAGTTTGTCCCG
TCTTCATCTATCTTATTTATTTAACCTGCCAGTGTGTGTCTAAGTATTTGTTTTGTTTTCTTTTTTCCTCTTTAAGAAAAGGAAAAGCTTGTCACAATCTAACTGGCTATGTTATTACTGTTAAATTT
ATGTTGTTTTGCAACTTAGAAACCAGCTACAGTATGGCCCACTTAATAAAACACCTGAGACAAA

hide sequence

RefSeq Acc Id:

XM_017589204 ⟹ XP_017444693

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	173,362,959 - 173,428,970 (-)	NCBI
mRatBN7.2	1	163,928,183 - 163,994,204 (-)	NCBI
Rnor_6.0	1	174,524,047 - 174,588,553 (-)	NCBI

Sequence:

show sequence

CGCGGTGGGGCGGGCGGCCGCTCTCCGCCCTTCCTCTAGCTTGCTCCGGCTGCGGTGCTTAGGA
CAGCGTCCAGGATGCGGCGCGGGGTGGCCTGGCGCCCCCCTGCCCCAGCACGGCAGCGGCGGCCGCTAGGACCCGGCGAGGCCCGGGGGCAGCGGCCGGAGCCTCGGTAGCGGCGGCGGAGGGAGCGG
CGGCTGAGGGCGAGCGGGCGGCCGGGGGCGGGGGCTCGGCTCCGCGCGGCTCGCCCCGCTCGGCCCGGCGCCATGAGCGGCGGCGGCGGCGGAGGGGGCTCGGCCCCCAGTCGCTTCGCCGACTATTT
TGTCATCTGCGGGCTGGACACCGAGACCGGGTTGGAGCCGGACGAGCTGTCGGGAGAAAATTTTGAGCAGACGCCATTGAGACGAACATTCAAGTCTAAGGTCCTTGCCCGATACCCTGAGAATGTAG
ACTGGAATCCGTTTGACCAGGATGCAGTGGGAATGCTGTGCATGCCCAAAGGGCTGGCATTCAAGACCCAGGCTGATCCCAGGGAGCCACAGTTCCATGCCTTTATTATCACAAGGGAGGATGGCTCT
CGGACATTTGGGTTTGCCCTTACCTTTTATGAAGAAGTTACCAGCAAGCAGATCTGCAGTGCAATGCAGACCCTCTACCACATGCACAACGCTGAGTATGATGTCCTTCATGCTCCACTTGCTGATGG
TGGAGACCAGAGTGGCATGGAAGACGGTGAAGGCATTCCTGGGACCAAGCTGCAGCGCTTCAACTCCTATGACATTAGCAGGGACACACTCTATGTTTCTAAATGCATCTGTCTCATCACACCCATGT
CTTTCATGAAGGCATGTCGGAGTGTGCTGCAGCAGCTCCACCAGGCAGTCACGTCACCTCAGCCCCCTCCTCTGCCCCTCGAGAGCTACATATACAATGTACTCTATGAGGTGCCACTTCCACCTCCT
GGCCGCTCCCTGAAGTTTTCTGGGGTCTATGGGCCAATAATCTGCCAGAGACCAAGTACCAATGAGCTTCCTCTATTTGATTTCCCTGTCAAAGAGGTCTTTGAACTGCTTGGGGTGGAGAATGTGTT
TCAGCTTTTTACTTGTGCCCTTCTGGAGTTTCAAATACTGCTCTACTCACAGCATTACCAGAGACTGATGACCGTGGCGGAGACAATTACAGCTCTGATGTTTCCTTTCCAATGGCAGCATGTCTATG
TCCCCATTCTCCCAGCTTCTCTCCTGCATTTCTTAGACGCTCCTGTTCCGTACCTGATGGGGTTGCACTCCAACGGCTTGGATGACCGCTCAAAGTTGGAGCTGCCTCAGGAGGCTAACCTCTGCTTT
GTGGATGTTGACAACCACTTCATTGAGTTGCCAGAGGACTTGCCTCAATTTCCTAACAAACTGGAGTTTGTCCAGGAGGTCTCTGAGATCCTCATGGCCTTCGGCGTTCCCCCTGAAGGGAACCTCCA
CTGCAGCGAAAGTGCTTCGAAGCTGAAGAGGATCCGAGCCTCCGAGCTTGTGTCTGACAAGAAGAACGGGAACATTGCGGGCTCCCCTTTGCATTCCTATGAGCTCCTCAAGGAAAATGAAACGATCG
CTCGGTTGCAAGCTTTGGTCAAGAGGACTGGAGTGAGTTTGGAAAAACTGGAAGTTCGTGAAGATCCCAGTAGCAATAAAGATTTCAAAGTTCAGTGTGATGAAGAAGAACTCAGGATTTACCAGCTA
AACATTCAGATCCGGGAAGTTTTTGCCAATCGCTTTACCCAGATGTTTGCTGATTATGAAGTGTTTGTCATCCAGCCCAGCCAGGATAAGGAGTCCTGGCTCAGCAACAGGGAGCAGATGCAGAACTT
TGATAAAGCGTCCTTTCTGTCAGATCAGCCTGAGCCCTACCTGCCCTTCCTCTCAAGATTCCTAGAGACCCAGATGTTTGCATCTTTTATTGACAACAAGATCATGTGTCACGATGATGACGATAAAG
ACCCTGTCCTCCGGGTCTTTGACTCAAGGGTAGACAAGATCAGACTGTTGAATGTTCGAACACCTACTCTTAGGACATCCATGTACCAGAAATGTACCACTGTGGATGAAGCAGAAAAAGCAATTGAG
CTACGTCTGGCAAAAATTGACCACACTGCAGTTCACCCTCATCTTCTTGACATGAAAATTGGACAAGGAAAATATGAACCTGGCTTTTTCCCTAAGCTACAATCAGATGTACTTTGCACCGGGCCAGC
CAGCAACAAGTGGACAAAAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGACCGGCAGAAGCAGCACACGGAACACTTGCGCTTAGACAATGACCAGAGGGAGAAGTACATCCAGGAAGCCAGGAATA
TGGGCAGTACCATCCGTCAGCCCAAACTGTCCAACCTGTCTCCCTCGGTCATTGCCCAGACCAACTGGAAGTTTGTAGAAGGCCTGCTGAAGGAATGCCGAAACAAGACCAAGAGGATGCTGGTAGAG
AAGATGGGTCGAGAGGCAGTGGAGCTGGGGCATGGGGAAGTGAACATCACCGGTGTGGAAGAGAATACTTTGATTGCCAGCCTCTGTGACCTTCTGGAAAGGATCTGGAGCCACGGGCTACAAGTAAA
ACAGGGGAAGTCAGCTTTGTGGTCTCATTTGTTACATTATCAGGAAAACCGGCAGAGAAAACTCACATCAGGAAGCCTCAGTACCTCAGGAATACTTCTTGATTCAGAACGGAGAAAGTCTGACGCCA
GTGCTGTCATGTCTCCCCTGAGGGTCTCCTTAATCCAGGATATGAGGCACATTCAGAATATTGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAGAAGAAGCTA
CTCTCCAGACATCTGAAGCAGCTTCTTTCAGACCATGAGCTCACCAAGAAGCTGTACAAGCGTTATGCCTTCCTGCGCTGCGATGACGAGAAGGAGCAGTTCCTCTATCACCTGCTCTCCTTCAACGC
AGTGGACTACTTCTGCTTCACCAATGTCTTCACAACCATCCTGATCCCATACCACATTTTGATTGTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACCGCCAATCCATGGATCTGTATATCAGGAG
AACTGGGTGAAACACAGATCCTGCAGATCCCCAGGAATGTGCTAGAGATGACTTTTGAGTGCCAGAACCTGGGGAAGCTCACAACTGTCCAGATTGGCCACGATAATTCTGGGCTGTATGCCAAATGG
CTTGTGGAATATGTGATGGTCAGGAATGAGATCACAGGACATACCTACAAGTTTCCATGTGGCCGATGGCTGGGCAAGGGTATGGATGATGGAAGCCTGGAGCGTGTGCTTGTTGGGGAGCTGCTCAC
GTCCCTACCCGAGGTAGACGAGAGGCCTTGTCGGACTCCACCACTGCAGCAGTCCCCCAGCGTCATCCGGAGACTTGTGACCATCTCACCCAACAATAAGCCCAAGCTGAACACAGGGCAGATCCAGG
AATCCATCGGGGAGGCGGTCAATGGCATTGTGAAGCACTTCCATAAACCTGAGAAAGAGCGTGGCAGTCTGACGCTGTTGCTTTGTGGAGAGTGTGGTCTCGTTTCAGCACTGGAGCAAGCTTTCCAG
CATGGATTTAAATCACCCCGGCTCTTCAAAAATGTCTTCATTTGGGACTTCCTGGAGAAAGCACAAACCTATTATGAGACGTTAGAGCAGAATGATGTAGTCCCAGAGGAAAACTGGCACACACGGGC
CCGCAACTTCTGCCGATTTGTCACCGCAGTCAACAACACGCCTCGGAACATCGGCAAGGACGGCAAATTTCAGATGCTGGTGTGCCTGGGAGCCAGAGATCACCTCCTGCACCACTGGATAGCCTTGC
TGGCCGACTGTCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAGGACCACACGCTCGTCAATTCTTTGATCCGAGTGCTGCAGACCCTGCAAGAATTCAACATCACACTGGACACCTCC
CTTGTGAAGGGCATTGACATCTGAGCTCCCGGCCCCAGCCAGCAGCAAGACCCAGGAGGACGCCCCACAGCTCGGCCTCCTCATCCCAGAGGGACCCAAGCAGGCCGTGAGGGACAGAGAGGATGTGT
ATACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAAAAAATAATCTATTTTAGAGTTTATTTGCTTCCTGCTTTTTACACACTTTCATGTGAGAGAGACAGGAGAGGGCGAGGCTGGTGCTGCTTG
TTTTGAAGCTGGTGCCTCCCTTGCACGGCCGCACGCTGGGAGCCTGTGGCCTCCCAGGCTGAGCCTGCACACACGTCACATCGATGAGGCCATTCCACATCGTTTTTAACTAATGTTTTCTATATTAA
CATTATTCTGGCTCTCTGGCTTTCACGGGCCATGCACAGGTGTGCGAGTGGGAGATCCCATGCTCAAAGGGATTTTTAGCAGTGCCTGTGATCAAGCACTGCGGAGTCAGCCCCACATCCGTTTCCCC
CTTCCCCTTTTTTGTCAGTATTATTTGGGAAGGAGATATGCCAGGACAATGTCATCGTGCTACCGTCATGCAGAAAATCATGTTTCCTGTTGGCACAACGTTGCGCAGAAGTAAACATGAGCATGTTG
TAACCAGTTTGTCCCGTCTTCATCTATCTTATTTATTTAACCTGCCAGTGTGTGTCTAAGTATTTGTTTTGTTTTCTTTTTTCCTCTTTAAGAAAAGGAAAAGCTTGTCACAATCTAACTGGCTATGT
TATTACTGTTAAATTTATGTTGTTTTGCAACTTAGAAACCAGCTACAGTATGGCCCACTTAATAAAACACCTGAGACAAA

hide sequence

RefSeq Acc Id:

XM_039078190 ⟹ XP_038934118

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	173,381,834 - 173,428,973 (-)	NCBI
mRatBN7.2	1	163,947,053 - 163,994,207 (-)	NCBI


Protein RefSeqs	NP_001101016	(Get FASTA)	NCBI Sequence Viewer
	XP_017444693	(Get FASTA)	NCBI Sequence Viewer
	XP_038934118	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68925	(Get FASTA)	NCBI Sequence Viewer
	EDM17883	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017485
	ENSRNOP00000017485.4
	ENSRNOP00000096686
GenBank Protein	G3V7Q0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001101016 ⟸ NM_001107546

- UniProtKB:

G3V7Q0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGS
RTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADGGDQSGMEDGEGIPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPP
GRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCF
VDVDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGVPPEGNLHCSESASKLKRIRASELVSDKKNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELRIYQL
NIQIREVFANRFTQMFADYEVFVIQPSQDKESWLSNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIE
LRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVE
KMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGILLDSERRKSDASAVMSPLRVSLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKL
LSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKW
LVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSLPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQ
HGFKSPRLFKNVFIWDFLEKAQTYYETLEQNDVVPEENWHTRARNFCRFVTAVNNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLDTS
LVKGIDI

hide sequence

RefSeq Acc Id:	XP_017444693 ⟸ XM_017589204
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AMA0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSGENFEQTPLRRTFKSKVLARYPENVDWN PFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADGGDQSGMEDGEGIPGTKLQRFNSYDISRDTLYVSKCICLITPMSFM KACRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPI LPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGVPPEGNLHCSESASKLKRIRASELVSDKKNGNIAGSPLHSYELLKENETIARL QALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWLSNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPV LRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGS TIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGILLDSERRKSDASAV MSPLRVSLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELG ETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSLPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESI GEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNDVVPEENWHTRARNFCRFVTAVNNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLAD CPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLDTSLVKGIDI hide sequence

Ensembl Acc Id:

ENSRNOP00000017485 ⟸ ENSRNOT00000017485

RefSeq Acc Id:	XP_038934118 ⟸ XM_039078190
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000096686 ⟸ ENSRNOT00000106309

Protein Domains

cDENN dDENN PLAT RUN uDENN

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V7Q0-F1-model_v2	AlphaFold	G3V7Q0	1-1287	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13690307

Promoter ID:

EPDNEW_R832

Type:

multiple initiation site

Name:

Dennd5a_1

Description:

DENN domain containing 5A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	174,588,516 - 174,588,576	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-57851	BioCyc
Ensembl Genes	ENSRNOG00000012206	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000017485	ENTREZGENE
	ENSRNOT00000017485.7	UniProtKB/Swiss-Prot
	ENSRNOT00000106309	ENTREZGENE
Gene3D-CATH	1.20.58.900	UniProtKB/Swiss-Prot
	3.30.450.200	UniProtKB/Swiss-Prot
	3.40.50.11500	UniProtKB/Swiss-Prot
	PLAT/LH2 domain	UniProtKB/Swiss-Prot
InterPro	cDENN_dom	UniProtKB/Swiss-Prot
	dDENN_dom	UniProtKB/Swiss-Prot
	DEN5A/B	UniProtKB/Swiss-Prot
	DENN_C	UniProtKB/Swiss-Prot
	PLAT/LH2_dom	UniProtKB/Swiss-Prot
	PLAT/LH2_dom_sf	UniProtKB/Swiss-Prot
	PLAT_RAB6IP1	UniProtKB/Swiss-Prot
	RUN1_DENND5A	UniProtKB/Swiss-Prot
	RUN2_DENND5A	UniProtKB/Swiss-Prot
	Run_dom	UniProtKB/Swiss-Prot
	Run_dom_sf	UniProtKB/Swiss-Prot
	Tripartite_DENN	UniProtKB/Swiss-Prot
	uDENN_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:308942	UniProtKB/Swiss-Prot
NCBI Gene	308942	ENTREZGENE
PANTHER	DENN DOMAIN-CONTAINING PROTEIN 5A	UniProtKB/Swiss-Prot
	PINSTRIPE, ISOFORM A	UniProtKB/Swiss-Prot
Pfam	dDENN	UniProtKB/Swiss-Prot
	DENN	UniProtKB/Swiss-Prot
	PLAT	UniProtKB/Swiss-Prot
	RUN	UniProtKB/Swiss-Prot
	uDENN	UniProtKB/Swiss-Prot
PhenoGen	Dennd5a	PhenoGen
PROSITE	DENN	UniProtKB/Swiss-Prot
	PLAT	UniProtKB/Swiss-Prot
	RUN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000012206	RatGTEx
SMART	dDENN	UniProtKB/Swiss-Prot
	DENN	UniProtKB/Swiss-Prot
	RUN	UniProtKB/Swiss-Prot
	uDENN	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF140741	UniProtKB/Swiss-Prot
	SSF49723	UniProtKB/Swiss-Prot
UniProt	A0A8I6AMA0	ENTREZGENE, UniProtKB/TrEMBL
	B5DF49_RAT	UniProtKB/TrEMBL
	DEN5A_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Dennd5a	DENN domain containing 5A	Dennd5a	DENN/MADD domain containing 5A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Dennd5a	DENN/MADD domain containing 5A	Rab6ip1	Rab6 interacting protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Rab6ip1	Rab6 interacting protein 1	Rab6ip1_predicted	Rab6 interacting protein 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Rab6ip1_predicted	Rab6 interacting protein 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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