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ONTOLOGY REPORT - ANNOTATIONS

Term:apoptotic process
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Accession:GO:0006915 term browser browse the term
Definition:A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Synonyms:exact_synonym: apoptotic cell death;   apoptotic programmed cell death;   programmed cell death by apoptosis
 narrow_synonym: activation of apoptosis;   apoptosis;   apoptosis signaling;   apoptotic program;   type I programmed cell death
 broad_synonym: cell suicide;   cellular suicide
 related_synonym: apoptosis activator activity;   caspase-dependent programmed cell death;   commitment to apoptosis;   induction of apoptosis;   induction of apoptosis by p53;   signaling (initiator) caspase activity
 alt_id: GO:0006917;   GO:0008632
 xref: Wikipedia:Apoptosis
 never_in_taxon: NCBITaxon:2 ! Bacteria
 only_in_taxon: NCBITaxon:33154 ! Opisthokonta
 never_in_taxon: NCBITaxon:4896 ! Schizosaccharomyces pombe

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      biological_process 180413
        cellular process 159956
          cell death 20252
            programmed cell death 20252
              apoptotic process 19523
                anoikis + 321
                apoptotic mitochondrial changes + 1195
                apoptotic process in bone marrow cell + 70
                apoptotic process in response to mitochondrial fragmentation 10
                apoptotic process involved in development + 475
                apoptotic signaling pathway + 6523
                epithelial cell apoptotic process + 1774
                execution phase of apoptosis + 816
                fat cell apoptotic process + 30
                fibroblast apoptotic process + 341
                glial cell apoptotic process + 255
                hepatoblast apoptotic process 0
                inflammatory cell apoptotic process + 279
                leukocyte apoptotic process + 1430
                melanocyte apoptotic process 20
                mesenchymal cell apoptotic process + 189
                muscle cell apoptotic process + 1373
                myeloid cell apoptotic process + 473
                myofibroblast cell apoptotic process + 25
                negative regulation of apoptotic process + 9951
                neuron apoptotic process + 3919
                positive regulation of apoptotic process + 6618
                regulation of apoptotic process + 16098
                retinal cell apoptotic process + 83
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