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ONTOLOGY REPORT - ANNOTATIONS

Term:plasma cell differentiation
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Accession:GO:0002317 term browser browse the term
Definition:The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: plasma cell development


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plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of ISO MGI:2158439 (PMID:15240705) RGD PMID:15240705 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:2385534 (PMID:29259245) RGD PMID:29259245 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Itm2a integral membrane protein 2A acts_upstream_of_or_within ISO MGI:5645968 (PMID:24831988) RGD PMID:24831988 NCBI chr  X:72,486,383...72,492,344
Ensembl chr  X:72,486,381...72,492,363 		JBrowse link
G Lgals1 galectin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:21753146)		 Ensembl
RGD		 PMID:21753146 GO_REF:0000107 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Lgals8 galectin 8 acts_upstream_of_or_within ISO (PMID:21753146) RGD PMID:21753146 NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:5501251 (PMID:25124037) RGD PMID:25124037 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Nkx2-3 NK2 homeobox 3 acts_upstream_of_or_within ISO MGI:2448069 (PMID:10926756) RGD PMID:10926756 NCBI chr 1:242,478,130...242,481,083
Ensembl chr 1:242,478,130...242,481,083 		JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158439 (PMID:15240705) RGD PMID:15240705 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 acts_upstream_of ISO UniProtKB:P60568 (PMID:22962438) RGD PMID:22962438 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il2 interleukin 2 acts_upstream_of ISO UniProtKB:P22301 (PMID:22962438) RGD PMID:22962438 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
ISS
IEA		 (PMID:11460154)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:11460154 GO_REF:0000024 GO_REF:0000107 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    immune system process 2822
      leukocyte activation 1032
        lymphocyte activation 837
          B cell activation 297
            B cell activation involved in immune response 95
              mature B cell differentiation involved in immune response 33
                plasma cell differentiation 10
                  negative regulation of plasma cell differentiation 1
                  positive regulation of plasma cell differentiation 3
                  regulation of plasma cell differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 19692
    cellular process 18168
      cellular developmental process 4695
        cell differentiation 4694
          cell development 3269
            hemopoiesis 1061
              leukocyte differentiation 674
                mononuclear cell differentiation 544
                  lymphocyte differentiation 447
                    B cell differentiation 161
                      mature B cell differentiation 42
                        mature B cell differentiation involved in immune response 33
                          plasma cell differentiation 10
                            negative regulation of plasma cell differentiation 1
                            positive regulation of plasma cell differentiation 3
                            regulation of plasma cell differentiation + 4
paths to the root