Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:mature B cell differentiation
go back to main search page
Accession:GO:0002335 term browser browse the term
Definition:The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: mature B lymphocyte differentiation
 related_synonym: mature cell development


show annotations for term's descendants           Sort by:
mature B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of ISO
IEA		 MGI:5544783 (PMID:23918385)
GO_REF:0000107		 RGD
Ensembl		 PMID:23918385 GO_REF:0000107 NCBI chr  X:70,435,340...70,439,052
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Pou2f2 POU class 2 homeobox 2 acts_upstream_of_or_within ISO MGI:3028896 (PMID:8096198) RGD PMID:8096198 NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:80,685,741...80,724,261 		JBrowse link
B-1 B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd19 CD19 molecule involved_in ISO (PMID:7543183) RGD PMID:7543183 NCBI chr 1:190,417,853...190,424,494
Ensembl chr 1:180,987,286...180,993,975 		JBrowse link
G Malt1 MALT1 paracaspase acts_upstream_of_or_within ISO
IEA		 MGI:3639305 (PMID:14614861)
GO_REF:0000107		 RGD
Ensembl		 PMID:14614861 GO_REF:0000107 NCBI chr18:61,212,290...61,266,272
Ensembl chr18:58,942,299...58,994,260 		JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slamf8 SLAM family member 8 involved_in ISO (PMID:11313408) RGD PMID:11313408 NCBI chr13:87,580,081...87,589,941
Ensembl chr13:85,047,727...85,057,211 		JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmtm7 CKLF-like MARVEL transmembrane domain containing 7 acts_upstream_of_or_within ISO (PMID:24080084) RGD PMID:24080084 NCBI chr 8:123,326,233...123,353,148
Ensembl chr 8:114,448,042...114,474,621 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 IMP RGD PMID:19327106 RGD:41408336 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 acts_upstream_of_or_within ISO MGI:2181762 (PMID:14595020) RGD PMID:14595020 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Plcl2 phospholipase C-like 2 acts_upstream_of_or_within ISO
IEA		 MGI:2679632 (PMID:14517301)
GO_REF:0000107		 RGD
Ensembl		 PMID:14517301 GO_REF:0000107 NCBI chr 9:3,529,117...3,713,712
Ensembl chr 9:3,292,695...3,477,009 		JBrowse link
follicular B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf8 interferon regulatory factor 8 involved_in ISO
IEA		 UniProtKB:P17433 (PMID:31000603)
GO_REF:0000107		 RGD
Ensembl		 PMID:31000603 GO_REF:0000107 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Muc19 mucin 19, oligomeric acts_upstream_of_or_within ISO (PMID:37475871) RGD PMID:37475871 NCBI chr 7:124,897,424...125,018,582
Ensembl chr 7:123,017,896...123,139,053 		JBrowse link
G Plcg2 phospholipase C, gamma 2 acts_upstream_of_or_within ISO MGI:2386100 (PMID:12928432) RGD PMID:12928432 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO
IEA		 UniProtKB:P23611 (PMID:31000603)
GO_REF:0000107		 RGD
Ensembl		 PMID:31000603 GO_REF:0000107 NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
germinal center B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO
IEA		 MGI:1857117|MGI:2683027 (PMID:14607964)
GO_REF:0000107		 RGD
Ensembl		 PMID:14607964 GO_REF:0000107 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Cdh17 cadherin 17 involved_in ISO
IEA		 (PMID:15688343)
GO_REF:0000107		 RGD
Ensembl		 PMID:15688343 GO_REF:0000107 NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G Il21 interleukin 21 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23045607)		 UniProt
RGD		 PMID:23045607 GO_REF:0000024 NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23045607)		 UniProt
RGD		 PMID:23045607 GO_REF:0000024 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf8 interferon regulatory factor 8 involved_in ISO
IEA		 UniProtKB:P17433 (PMID:31000603)
GO_REF:0000107		 RGD
Ensembl		 PMID:31000603 GO_REF:0000107 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 acts_upstream_of_or_within ISO MGI:4235940 (PMID:23997217) RGD PMID:23997217 NCBI chr 4:163,371,125...163,384,676
Ensembl chr 4:161,684,249...161,698,422 		JBrowse link
G Phf14 PHD finger protein 14 involved_in ISO
IEA		 (PMID:33035772)
GO_REF:0000107		 RGD
Ensembl		 PMID:33035772 GO_REF:0000107 NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,009,264...40,195,885 		JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 involved_in ISO
IEA		 (PMID:23045607)
GO_REF:0000107		 RGD
Ensembl		 PMID:23045607 GO_REF:0000107 NCBI chr 8:60,418,173...60,445,176
Ensembl chr 8:51,474,015...51,548,819 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO
IEA		 UniProtKB:P23611 (PMID:31000603)
GO_REF:0000107		 RGD
Ensembl		 PMID:31000603 GO_REF:0000107 NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
marginal zone B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO MGI:1861796 (PMID:9009202) RGD PMID:9009202 NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Cdh17 cadherin 17 involved_in ISO
IEA		 (PMID:15688343)
GO_REF:0000107		 RGD
Ensembl		 PMID:15688343 GO_REF:0000107 NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15146182), (PMID:19217325)		 UniProt
RGD		 PMID:15146182 PMID:19217325 GO_REF:0000024 NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Dock10 dedicator of cytokinesis 10 involved_in ISO (PMID:25729399) RGD PMID:25729399 NCBI chr 9:89,291,936...89,549,871
Ensembl chr 9:81,843,604...82,101,525 		JBrowse link
G Dock11 dedicator of cytokinesis 11 involved_in ISO
IEA		 (PMID:25729399)
GO_REF:0000107		 RGD
Ensembl		 PMID:25729399 GO_REF:0000107 NCBI chr  X:119,997,523...120,180,643
Ensembl chr  X:115,131,909...115,314,854 		JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19217325)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19217325 GO_REF:0000024 GO_REF:0000107 NCBI chr12:19,144,474...19,152,951
Ensembl chr12:14,018,333...14,039,008 		JBrowse link
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in ISO
IEA		 (PMID:19217325)
GO_REF:0000107		 RGD
Ensembl		 PMID:19217325 GO_REF:0000107 NCBI chr 7:112,191,288...112,209,129
Ensembl chr 7:110,310,812...110,328,653 		JBrowse link
G Notch2 notch receptor 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19217325)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19217325 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO		 GO_REF:0000024
(PMID:10881171)		 UniProt
RGD		 PMID:10881171 GO_REF:0000024 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Taok3 TAO kinase 3 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr12:44,973,180...45,134,439
Ensembl chr12:39,314,027...39,461,244 		JBrowse link
mature B cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C10h17orf99 similar to human chromosome 17 open reading frame 99 involved_in ISO
IEA		 (PMID:28978694)
GO_REF:0000107		 RGD
Ensembl		 PMID:28978694 GO_REF:0000107 NCBI chr10:103,514,067...103,526,132
Ensembl chr10:103,016,505...103,027,407 		JBrowse link
G Gpr183 G protein-coupled receptor 183 involved_in ISO (PMID:19597478) RGD PMID:19597478 NCBI chr15:105,445,129...105,457,192
Ensembl chr15:99,036,367...99,050,559 		JBrowse link
G Rag2 recombination activating 2 IMP RGD PMID:30206106 RGD:38508903 NCBI chr 3:108,357,399...108,367,186
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
memory B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 involved_in ISO
IEA		 (PMID:10755614)
GO_REF:0000107		 RGD
Ensembl		 PMID:10755614 GO_REF:0000107 NCBI chr 7:100,734,300...100,802,443
Ensembl chr 7:98,845,270...98,913,236 		JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO
IEA		 MGI:2158439 (PMID:15240705)
GO_REF:0000107		 RGD
Ensembl		 PMID:15240705 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of ISO
IEA		 MGI:2158439 (PMID:15240705)
GO_REF:0000107		 RGD
Ensembl		 PMID:15240705 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:2385534 (PMID:29259245) RGD PMID:29259245 NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Itm2a integral membrane protein 2A acts_upstream_of_or_within ISO
IEA		 MGI:5645968 (PMID:24831988)
GO_REF:0000107		 RGD
Ensembl		 PMID:24831988 GO_REF:0000107 NCBI chr  X:76,559,183...76,565,144
Ensembl chr  X:72,486,381...72,492,363 		JBrowse link
G Lgals1 galectin 1 acts_upstream_of_or_within ISO
IEA		 (PMID:21753146)
GO_REF:0000107		 RGD
Ensembl		 PMID:21753146 GO_REF:0000107 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Lgals8 galectin 8 acts_upstream_of_or_within ISO
IEA		 (PMID:21753146)
GO_REF:0000107		 RGD
Ensembl		 PMID:21753146 GO_REF:0000107 NCBI chr17:62,716,368...62,744,272
Ensembl chr17:58,028,105...58,052,764 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:5501251 (PMID:25124037) RGD PMID:25124037 NCBI chr11:58,251,720...58,279,767
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Nkx2-3 NK2 homeobox 3 acts_upstream_of_or_within ISO
IEA		 MGI:2448069 (PMID:10926756)
GO_REF:0000107		 RGD
Ensembl		 PMID:10926756 GO_REF:0000107 NCBI chr 1:252,427,356...252,430,309
Ensembl chr 1:242,478,130...242,481,083 		JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddrgk1 DDRGK domain containing 1 involved_in ISO
IEA		 (PMID:30842412)
GO_REF:0000107		 RGD
Ensembl		 PMID:30842412 GO_REF:0000107 NCBI chr 3:138,315,006...138,336,691
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Il10 interleukin 10 acts_upstream_of ISO
IEA		 UniProtKB:P60568 (PMID:22962438)
GO_REF:0000107		 RGD
Ensembl		 PMID:22962438 GO_REF:0000107 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il2 interleukin 2 acts_upstream_of ISO
IEA		 UniProtKB:P22301 (PMID:22962438)
GO_REF:0000107		 RGD
Ensembl		 PMID:22962438 GO_REF:0000107 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
ISS
IEA		 (PMID:11460154)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:11460154 GO_REF:0000024 GO_REF:0000107 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    immune system process 3130
      leukocyte activation 1082
        lymphocyte activation 875
          lymphocyte differentiation 453
            B cell differentiation 158
              mature B cell differentiation 45
                B-1 B cell differentiation + 7
                mature B cell differentiation involved in immune response + 36
Path 2
Term Annotations click to browse term
  biological_process 20558
    developmental process 7149
      cellular developmental process 4833
        cell differentiation 4832
          cell development 3350
            hemopoiesis 1083
              leukocyte differentiation 690
                mononuclear cell differentiation 556
                  lymphocyte differentiation 453
                    B cell differentiation 158
                      mature B cell differentiation 45
                        B-1 B cell differentiation + 7
                        mature B cell differentiation involved in immune response + 36
paths to the root