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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA double-strand break processing
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Accession:GO:0000729 term browser browse the term
Definition:The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.


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DNA double-strand break processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in IDA (PMID:10802669), (PMID:26240375) UniProt PMID:10802669 PMID:26240375 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,804...108,369,102 		JBrowse link
G BLM BLM RecQ like helicase involved_in IDA (PMID:21325134) UniProt PMID:21325134 NCBI chr15:90,717,346...90,816,166
Ensembl chr15:90,717,346...90,816,166 		JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IDA (PMID:21325134) UniProt PMID:21325134 NCBI chr10:68,414,064...68,472,521
Ensembl chr10:68,414,064...68,472,121 		JBrowse link
G EXD2 exonuclease 3'-5' domain containing 2 involved_in IDA (PMID:26807646) UniProt PMID:26807646 NCBI chr14:69,191,498...69,244,018
Ensembl chr14:69,191,498...69,244,020 		JBrowse link
G EXO1 exonuclease 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:241,847,986...241,889,939
Ensembl chr 1:241,847,967...241,895,148 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in TAS
IMP
NAS		 (PMID:23080121)
(PMID:26512707)		 Reactome
UniProt
ComplexPortal		 PMID:23080121 PMID:26512707 Reactome:R-HSA-5693608 NCBI chr11:94,415,570...94,512,412
Ensembl chr11:94,415,570...94,493,885 		JBrowse link
G NBN nibrin involved_in NAS
IDA		 (PMID:26512707)
(PMID:16622404)		 ComplexPortal
UniProt		 PMID:16622404 PMID:26512707 NCBI chr 8:89,933,331...89,984,667
Ensembl chr 8:89,924,515...90,003,228 		JBrowse link
G RAD50 RAD50 double strand break repair protein involved_in NAS
IDA		 (PMID:26512707)
(PMID:16622404), (PMID:21757780)		 ComplexPortal
UniProt		 PMID:16622404 PMID:21757780 PMID:26512707 NCBI chr 5:132,556,977...132,646,349
Ensembl chr 5:132,556,019...132,646,349 		JBrowse link
G SETMAR SET domain and mariner transposase fusion gene involved_in IDA
IBA
IEA		 (PMID:21491884) UniProt
GO_Central
TreeGrafter		 PMID:21491884 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:4,303,369...4,317,265
Ensembl chr 3:4,303,332...4,317,265 		JBrowse link
G SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 involved_in IMP (PMID:22960744) UniProt PMID:22960744 NCBI chr 4:94,207,608...94,291,292
Ensembl chr 4:94,207,611...94,291,292 		JBrowse link
G UBE2N ubiquitin conjugating enzyme E2 N involved_in IMP (PMID:17349954) HGNC-UCL PMID:17349954 NCBI chr12:93,405,684...93,441,947
Ensembl chr12:93,405,673...93,441,947 		JBrowse link
G UBE2V2 ubiquitin conjugating enzyme E2 V2 involved_in IMP (PMID:17349954) HGNC-UCL PMID:17349954 NCBI chr 8:47,997,437...48,064,708
Ensembl chr 8:48,008,415...48,064,708 		JBrowse link
DNA double-strand break processing involved in repair via single-strand annealing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HELQ helicase, POLQ like involved_in IDA (PMID:34937945) UniProt PMID:34937945 NCBI chr 4:83,407,346...83,455,883
Ensembl chr 4:83,407,343...83,455,855 		JBrowse link
G LOC130134321 SLX1A-like involved_in IMP (PMID:19595721) UniProt PMID:19595721
G RAD52 RAD52 homolog, DNA repair protein involved_in
acts_upstream_of_or_within		 IEA
IDA		 (PMID:19506022) Ensembl
MGI		 PMID:19506022 GO_REF:0000107 NCBI chr12:911,736...991,122
Ensembl chr12:911,736...990,053 		JBrowse link
G RBBP8 RB binding protein 8, endonuclease involved_in IMP
IBA		 (PMID:18716619), (PMID:19202191) UniProt
GO_Central		 PMID:18716619 PMID:19202191 GO_REF:0000033 NCBI chr18:22,914,139...23,026,486
Ensembl chr18:22,798,261...23,026,488 		JBrowse link
G RBBP8NL RBBP8 N-terminal like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:62,410,237...62,427,539
Ensembl chr20:62,410,237...62,427,539 		JBrowse link
G RNF138 ring finger protein 138 involved_in IMP
IEA
IBA		 (PMID:26502057) UniProt
TreeGrafter
GO_Central		 PMID:26502057 GO_REF:0000033 GO_REF:0000118 NCBI chr18:32,091,874...32,131,561
Ensembl chr18:32,091,874...32,131,561 		JBrowse link
G SLX1A SLX1 homolog A, structure-specific endonuclease subunit involved_in IMP (PMID:19595721) UniProt PMID:19595721 NCBI chr16:30,193,843...30,197,566
Ensembl chr16:30,193,875...30,197,561 		JBrowse link
G SLX1B SLX1 homolog B, structure-specific endonuclease subunit involved_in IMP (PMID:19595721) UniProt PMID:19595721 NCBI chr16:29,454,533...29,458,220
Ensembl chr16:29,454,533...29,458,219 		JBrowse link
G SLX4 SLX4 structure-specific endonuclease subunit involved_in IMP (PMID:19595721) UniProt PMID:19595721 NCBI chr16:3,581,181...3,611,606
Ensembl chr16:3,581,181...3,611,606 		JBrowse link
meiotic DNA double-strand break processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPO11 SPO11 initiator of meiotic double strand breaks involved_in IBA GO_Central GO_REF:0000033 NCBI chr20:57,329,803...57,343,993
Ensembl chr20:57,329,803...57,343,994 		JBrowse link
meiotic DNA double-strand break processing involved in reciprocal meiotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRIP1 BRCA1 interacting helicase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26490168) Ensembl
MGI		 PMID:26490168 GO_REF:0000107 NCBI chr17:61,679,139...61,863,528
Ensembl chr17:61,679,139...61,863,559 		JBrowse link
G C14orf39 chromosome 14 open reading frame 39 involved_in ISS
IBA
IEA		 UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr14:60,435,956...60,515,544
Ensembl chr14:60,396,469...60,515,543 		JBrowse link
regulation of DNA double-strand break processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HELB DNA helicase B involved_in IMP
IEA		 (PMID:26774285) UniProt
Ensembl		 PMID:26774285 GO_REF:0000107 NCBI chr12:66,302,493...66,343,643
Ensembl chr12:66,302,493...66,343,643 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    metabolic process 12437
      primary metabolic process 10668
        nucleobase-containing compound metabolic process 6508
          nucleic acid metabolic process 5904
            DNA metabolic process 1074
              DNA double-strand break processing 25
                DNA double-strand break processing involved in repair via single-strand annealing 9
                DNA double-strand break processing involved in repair via synthesis-dependent strand annealing 0
                meiotic DNA double-strand break processing + 3
                regulation of DNA double-strand break processing 1
Path 2
Term Annotations click to browse term
  biological_process 19612
    metabolic process 12437
      organic substance metabolic process 11940
        organic cyclic compound metabolic process 7044
          nucleobase-containing compound metabolic process 6508
            nucleic acid metabolic process 5904
              DNA metabolic process 1074
                DNA repair 647
                  double-strand break repair 328
                    DNA double-strand break processing 25
                      DNA double-strand break processing involved in repair via single-strand annealing 9
                      DNA double-strand break processing involved in repair via synthesis-dependent strand annealing 0
                      meiotic DNA double-strand break processing + 3
                      regulation of DNA double-strand break processing 1
paths to the root