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ONTOLOGY REPORT - ANNOTATIONS


Term:double-strand break repair
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Accession:GO:0006302 term browser browse the term
Definition:The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
Comment:Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'.


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double-strand break repair term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abraxas1 abraxas 1, BRCA1 A complex subunit JBrowse link 14 10,424,674 10,439,010 RGD:1600115
RGD:1624291
G Actr5 actin related protein 5 JBrowse link 3 155,118,567 155,132,073 RGD:1624291
RGD:13792537
G Actr8 actin related protein 8 JBrowse link 16 6,047,977 6,062,586 RGD:13792537
G Apbb1 amyloid beta precursor protein binding family B member 1 JBrowse link 1 170,387,625 170,411,263 RGD:8553580
RGD:1624291
G Aplf aprataxin and PNKP like factor JBrowse link 4 119,514,822 119,568,764 RGD:1624291
RGD:13792537
G Aptx aprataxin JBrowse link 5 56,987,714 57,009,481 RGD:1624291
RGD:13792537
G Babam1 BRISC and BRCA1 A complex member 1 JBrowse link 16 19,792,720 19,798,886 RGD:1600115
RGD:1624291
G Babam2 BRISC and BRCA1 A complex member 2 JBrowse link 6 25,666,654 26,135,888 RGD:1624291
RGD:1600115
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:1624291
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:1624291
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 JBrowse link 9 9,863,380 9,865,920 RGD:1600115
RGD:13792537
RGD:1624291
G Cdca5 cell division cycle associated 5 JBrowse link 1 221,448,661 221,462,235 RGD:1624291
RGD:13792537
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
G Dclre1c DNA cross-link repair 1C JBrowse link 17 78,782,512 78,812,140 RGD:1624291
G Ddx1 DEAD-box helicase 1 JBrowse link 6 38,422,892 38,453,762 RGD:1624291
RGD:1600115
G Dtx3l deltex E3 ubiquitin ligase 3L JBrowse link 11
11
67,758,093
67,768,542
67,767,623
67,772,428
RGD:1624291
G Eme1 essential meiotic structure-specific endonuclease 1 JBrowse link 10 82,366,820 82,375,510 RGD:13792537
G Eme2 essential meiotic structure-specific endonuclease subunit 2 JBrowse link 10 14,253,552 14,257,017 RGD:13792537
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:1624291
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 JBrowse link 15 42,500,929 42,519,019 RGD:1624291
G Exd2 exonuclease 3'-5' domain containing 2 JBrowse link 6 104,017,620 104,051,442 RGD:1624291
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:1624291
RGD:1600115
G Eya3 EYA transcriptional coactivator and phosphatase 3 JBrowse link 5 150,833,754 150,915,390 RGD:1624291
G Ggn gametogenetin JBrowse link 1 88,112,873 88,116,990 RGD:1624291
G Ino80 INO80 complex ATPase subunit JBrowse link 3 111,186,371 111,266,542 RGD:1624291
G Kat5 lysine acetyltransferase 5 JBrowse link 1 220,967,795 220,974,596 RGD:1600115
RGD:1624291
G Lig3 DNA ligase 3 JBrowse link 10 70,134,734 70,158,051 RGD:1624291
G Lig4 DNA ligase 4 JBrowse link 16 85,331,771 85,339,496 RGD:1624291
G LOC103689943 meiosis arrest female protein 1-like JBrowse link 10 28,267 72,912 RGD:1624291
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link 5 164,943,183 164,956,255 RGD:1624291
RGD:1600115
G Marf1 meiosis regulator and mRNA stability factor 1 JBrowse link 10 908,806 953,481 RGD:1624291
G Meioc meiosis specific with coiled-coil domain JBrowse link 10 90,622,954 90,641,883 RGD:1624291
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1624291
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:1624291
RGD:1600115
G Mta1 metastasis associated 1 JBrowse link 6 137,911,302 137,950,066 RGD:1600115
RGD:13792537
RGD:1624291
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:1600115
RGD:1624291
G Nipbl NIPBL, cohesin loading factor JBrowse link 2 57,508,830 57,676,197 RGD:13792537
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:1624291
RGD:13792537
RGD:1600115
G Parp2 poly (ADP-ribose) polymerase 2 JBrowse link 15 27,739,416 27,749,650 RGD:13792537
G Parp3 poly (ADP-ribose) polymerase family, member 3 JBrowse link 8 115,173,440 115,179,543 RGD:1624291
RGD:13792537
G Parp9 poly (ADP-ribose) polymerase family, member 9 JBrowse link 11 67,724,071 67,758,027 RGD:1624291
G Polq DNA polymerase theta JBrowse link 11 66,585,860 66,695,369 RGD:1624291
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:1624291
RGD:13792537
G Rad21 RAD21 cohesin complex component JBrowse link 7 91,511,755 91,538,673 RGD:13792537
G Rad21l1 RAD21 cohesin complex component like 1 JBrowse link 3 147,163,335 147,191,008 RGD:1624291
RGD:13792537
G Rad50 RAD50 double strand break repair protein JBrowse link 10 39,002,130 39,054,042 RGD:68816
RGD:1600115
RGD:1624291
G Rad54l RAD54 like JBrowse link 5 134,948,511 134,978,125 RGD:1624291
G Rec8 REC8 meiotic recombination protein JBrowse link 15 34,296,922 34,304,387 RGD:13792537
G Rnf168 ring finger protein 168 JBrowse link 11 71,721,242 71,743,421 RGD:1600115
RGD:1624291
G Rnf8 ring finger protein 8 JBrowse link 20 8,285,380 8,309,858 RGD:1600115
RGD:13792537
RGD:1624291
G Setx senataxin JBrowse link 3 7,680,430 7,731,815 RGD:1624291
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 JBrowse link 9 119,675,750 119,818,620 RGD:1600115
G Tdp1 tyrosyl-DNA phosphodiesterase 1 JBrowse link 6 123,895,860 123,963,688 RGD:1600115
RGD:13792537
RGD:1624291
G Tdp2 tyrosyl-DNA phosphodiesterase 2 JBrowse link 17 42,229,667 42,241,025 RGD:1600115
RGD:13792537
RGD:1624291
G Tnks1bp1 tankyrase 1 binding protein 1 JBrowse link 3 72,458,520 72,483,206 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Trip13 thyroid hormone receptor interactor 13 JBrowse link 1 31,967,980 32,012,923 RGD:1600115
RGD:1624291
G Uimc1 ubiquitin interaction motif containing 1 JBrowse link 17 10,061,915 10,130,921 RGD:1600115
RGD:13792537
RGD:1624291
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1600115
RGD:1624291
G Wrn WRN RecQ like helicase JBrowse link 16 62,483,773 62,619,018 RGD:1624291
G Xrcc4 X-ray repair cross complementing 4 JBrowse link 2 18,674,496 18,927,463 RGD:1624291
G Xrcc5 X-ray repair cross complementing 5 JBrowse link 9 79,659,275 79,748,050 RGD:727219
RGD:1624291
G Xrcc6 X-ray repair cross complementing 6 JBrowse link 7 123,259,881 123,280,613 RGD:727219
RGD:1624291
DNA double-strand break processing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:1624291
G Dna2 DNA replication helicase/nuclease 2 RGD:1600115
G Exd2 exonuclease 3'-5' domain containing 2 JBrowse link 6 104,017,620 104,051,442 RGD:1624291
G Setmar SET domain and mariner transposase fusion gene JBrowse link 4 140,092,346 140,104,495 RGD:1624291
G Slc25a16 solute carrier family 25 member 16 JBrowse link 20 27,283,383 27,308,069 RGD:1600115
G Smarcad1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1` JBrowse link 4 95,884,020 95,945,248 RGD:1624291
RGD:1600115
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:1624291
G Ube2v2 ubiquitin conjugating enzyme E2 V2 JBrowse link 11 89,557,273 89,591,175 RGD:1624291
DNA double-strand break processing involved in repair via single-strand annealing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 4 152,429,826 152,451,875 RGD:1624291
G Rbbp8 RB binding protein 8, endonuclease JBrowse link 18 3,134,630 3,227,702 RGD:1600115
RGD:13792537
RGD:1624291
G RGD1565844 similar to RIKEN cDNA 1700045I19 JBrowse link X 32,495,573 32,496,646 RGD:13792537
G Rnf138 ring finger protein 138 JBrowse link 18 15,146,925 15,167,361 RGD:1624291
RGD:13792537
RGD:1600115
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit JBrowse link 1 198,114,514 198,120,061 RGD:1624291
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:1624291
DNA recombinase assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07067300.1 RGD:13792537
G Dmc1 DNA meiotic recombinase 1 JBrowse link 7 120,796,217 120,840,524 RGD:13792537
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:1624291
RGD:13792537
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 4 152,429,826 152,451,875 RGD:1600115
G Swi5 SWI5 homologous recombination repair protein JBrowse link 3 11,307,981 11,317,049 RGD:13792537
double-strand break repair involved in meiotic recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brip1 BRCA1 interacting protein C-terminal helicase 1 JBrowse link 10 73,507,009 73,632,742 RGD:1624291
RGD:13792537
G Fancd2 FA complementation group D2 JBrowse link 4 145,489,869 145,551,479 RGD:13792537
G Mcmdc2 minichromosome maintenance domain containing 2 JBrowse link 5 8,973,861 9,039,616 RGD:1624291
RGD:1600115
G Morc2b microrchidia 2B JBrowse link 7 15,479,754 15,483,834 RGD:1600115
G Prdm9 PR/SET domain 9 JBrowse link 1 57,533,602 57,555,155 RGD:1600115
RGD:1624291
G Spo11 SPO11, initiator of meiotic double stranded breaks JBrowse link 3 170,991,573 171,008,226 RGD:1624291
double-strand break repair via alternative nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmces 5-hydroxymethylcytosine binding, ES cell specific JBrowse link 4 119,841,088 119,864,115 RGD:1624291
G Lig3 DNA ligase 3 JBrowse link 10 70,134,734 70,158,051 RGD:1624291
RGD:13792537
G Polq DNA polymerase theta JBrowse link 11 66,585,860 66,695,369 RGD:1624291
double-strand break repair via break-induced replication term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc45 cell division cycle 45 JBrowse link 11 86,328,785 86,354,099 RGD:13792537
G Cdc7 cell division cycle 7 JBrowse link 14 3,826,658 3,846,891 RGD:13792537
G Gins2 GINS complex subunit 2 JBrowse link 19 54,151,048 54,163,701 RGD:13792537
G Gins4 GINS complex subunit 4 JBrowse link 16 73,584,412 73,596,808 RGD:13792537
G Mcm2 minichromosome maintenance complex component 2 JBrowse link 4 120,825,699 120,840,221 RGD:13792537
G Mcm3 minichromosome maintenance complex component 3 JBrowse link 9 26,914,057 26,932,201 RGD:13792537
G Mcm4 minichromosome maintenance complex component 4 JBrowse link 11 89,511,191 89,524,892 RGD:13792537
G Mcm5 minichromosome maintenance complex component 5 JBrowse link 19 14,523,482 14,561,281 RGD:13792537
G Mcm6 minichromosome maintenance complex component 6 JBrowse link 13 45,042,882 45,068,073 RGD:13792537
G Mcm7 minichromosome maintenance complex component 7 JBrowse link 12 19,306,615 19,313,877 RGD:13792537
G Mus81 MUS81 structure-specific endonuclease subunit JBrowse link 1 220,862,474 220,867,973 RGD:13792537
double-strand break repair via classical nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:1624291
G Ercc8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit JBrowse link 2 39,434,617 39,473,392 RGD:1624291
G Lig4 DNA ligase 4 JBrowse link 16 85,331,771 85,339,496 RGD:1624291
G Uvrag UV radiation resistance associated JBrowse link 1 163,844,804 164,101,568 RGD:1624291
G Xrcc6 X-ray repair cross complementing 6 JBrowse link 7 123,259,881 123,280,613 RGD:1624291
G Zbtb7a zinc finger and BTB domain containing 7a JBrowse link 7 11,429,266 11,446,119 RGD:1600115
RGD:1624291
double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC117889.1 RGD:13792537
G Ap5s1 adaptor related protein complex 5 subunit sigma 1 JBrowse link 3 123,754,035 123,757,349 RGD:1624291
G Ap5z1 adaptor related protein complex 5 subunit zeta 1 JBrowse link 12 14,161,998 14,175,997 RGD:1624291
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291
G Aunip aurora kinase A and ninein interacting protein JBrowse link 5 152,721,799 152,734,577 RGD:1624291
RGD:1600115
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:13792537
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:1624291
RGD:13792537
RGD:1600115
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:1624291
RGD:13792537
RGD:1600115
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 10 2,010,140 2,037,953 RGD:1624291
G Exd2 exonuclease 3'-5' domain containing 2 JBrowse link 6 104,017,620 104,051,442 RGD:1624291
G Fan1 FANCD2 and FANCI associated nuclease 1 JBrowse link 1 125,182,117 125,209,772 RGD:1624291
G Fbh1 F-box DNA helicase 1 JBrowse link 17 70,399,093 70,437,151 RGD:13792537
G Gen1 GEN1 Holliday junction 5' flap endonuclease JBrowse link 6 36,910,064 36,940,868 RGD:1624291
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:1624291
G Helq helicase, POLQ-like JBrowse link 14 10,446,981 10,491,042 RGD:1624291
G Hus1 HUS1 checkpoint clamp component JBrowse link 14 89,194,086 89,208,825 RGD:1624291
RGD:13792537
G Ino80 INO80 complex ATPase subunit JBrowse link 3 111,186,371 111,266,542 RGD:1624291
G Kash5 KASH domain containing 5 JBrowse link 1 101,180,497 101,203,048 RGD:1624291
G Kdm4d lysine demethylase 4D JBrowse link 8 12,968,192 12,993,651 RGD:1624291
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor JBrowse link 3 125,470,499 125,500,795 RGD:1624291
RGD:13792537
RGD:1600115
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor JBrowse link 20 34,818,093 34,930,157 RGD:1624291
RGD:13792537
G Mcmdc1 minichromosome maintenance deficient domain containing 1 RGD:1600115
RGD:13792537
G Meiob meiosis specific with OB-fold JBrowse link 10 14,174,645 14,206,026 RGD:1600115
RGD:1624291
G Mms22l MMS22-like, DNA repair protein JBrowse link 5 38,844,502 38,960,989 RGD:1624291
RGD:13792537
G Morf4l1 mortality factor 4 like 1 JBrowse link 8 97,473,454 97,494,974 RGD:1624291
RGD:1600115
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1600115
RGD:1624291
RGD:13792537
G Nabp1 nucleic acid binding protein 1 JBrowse link 9 55,049,893 55,057,784 RGD:1624291
RGD:13792537
RGD:1600115
G Nabp2 nucleic acid binding protein 2 JBrowse link 7 2,820,006 2,825,627 RGD:1600115
RGD:13792537
RGD:1624291
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:13792537
G Nsmce1 NSE1 homolog, SMC5-SMC6 complex component JBrowse link 1 196,857,490 196,883,907 RGD:13792537
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase JBrowse link 7 99,677,295 99,900,765 RGD:1600115
RGD:1624291
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 JBrowse link 13 48,679,726 48,709,663 RGD:1624291
G Palb2 partner and localizer of BRCA2 JBrowse link 1 192,064,586 192,088,547 RGD:1624291
G Poll DNA polymerase lambda JBrowse link 1 265,290,337 265,298,847 RGD:1624291
RGD:1600115
G Poln DNA polymerase nu JBrowse link 14 81,837,764 82,037,999 RGD:1624291
G Psmd14 proteasome 26S subunit, non-ATPase 14 JBrowse link 3 47,578,449 47,673,330 RGD:1624291
G Rad21l1 RAD21 cohesin complex component like 1 JBrowse link 3 147,163,335 147,191,008 RGD:1624291
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:9831188
RGD:1624291
G Rad51ap1 RAD51 associated protein 1 JBrowse link 4 159,469,803 159,482,869 RGD:1624291
G Rad51b RAD51 paralog B JBrowse link 6 102,473,978 103,018,185 RGD:1624291
RGD:13792537
G Rad51c RAD51 paralog C JBrowse link 10 74,697,713 74,724,004 RGD:1624291
G Rad51d RAD51 paralog D JBrowse link 10 70,222,703 70,241,352 RGD:1624291
RGD:13792537
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 4 152,429,826 152,451,875 RGD:1624291
RGD:13792537
G Rad54b RAD54 homolog B JBrowse link 5 25,140,531 25,214,469 RGD:1624291
RGD:13792537
G Rad54l RAD54 like JBrowse link 5 134,948,511 134,978,125 RGD:1624291
G Rbbp8 RB binding protein 8, endonuclease JBrowse link 18 3,134,630 3,227,702 RGD:1600115
RGD:13792537
G Rec8 REC8 meiotic recombination protein JBrowse link 15 34,296,922 34,304,387 RGD:1624291
G Recql RecQ like helicase JBrowse link 4 176,581,892 176,606,520 RGD:13792537
G Recql4 RecQ like helicase 4 JBrowse link 7 117,765,892 117,773,128 RGD:13792537
G Recql5 RecQ like helicase 5 JBrowse link 10 104,443,735 104,482,889 RGD:13792537
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit JBrowse link 20 44,803,664 44,961,362 RGD:13792537
G Rfwd3 ring finger and WD repeat domain 3 JBrowse link 19 42,960,597 42,971,894 RGD:1624291
G RGD1565844 similar to RIKEN cDNA 1700045I19 JBrowse link X 32,495,573 32,496,646 RGD:13792537
G Rmi1 RecQ mediated genome instability 1 JBrowse link 17 6,658,285 6,665,618 RGD:13792537
G Rnf138 ring finger protein 138 JBrowse link 18 15,146,925 15,167,361 RGD:1600115
RGD:13792537
RGD:1624291
G Rpa1 replication protein A1 JBrowse link 10 62,140,419 62,191,518 RGD:1624291
RGD:13792537
G Rpa2 replication protein A2 JBrowse link 5 150,957,041 150,967,597 RGD:1624291
RGD:13792537
RGD:1600115
G Rpa3 replication protein A3 JBrowse link 4 34,279,320 34,282,351 RGD:1624291
RGD:13792537
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 JBrowse link 3 153,210,829 153,250,705 RGD:1624291
G Sem1 SEM1, 26S proteasome complex subunit JBrowse link 4 32,067,444 32,087,600 RGD:1624291
RGD:13792537
G Sfpq splicing factor proline and glutamine rich JBrowse link 5 145,079,803 145,088,517 RGD:1624291
G Sfr1 SWI5-dependent homologous recombination repair protein 1 JBrowse link 1 267,505,336 267,509,350 RGD:1600115
RGD:13792537
RGD:1624291
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit JBrowse link 1 198,114,514 198,120,061 RGD:1624291
RGD:13792537
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:1624291
G Smc5 structural maintenance of chromosomes 5 JBrowse link 1 240,977,898 241,046,273 RGD:1624291
G Spidr scaffold protein involved in DNA repair JBrowse link 11 89,009,931 89,260,361 RGD:1624291
RGD:13792537
G Stn1 STN1 subunit of CST complex JBrowse link 1 267,281,786 267,315,714 RGD:13792537
G Swi5 SWI5 homologous recombination repair protein JBrowse link 3 11,307,981 11,317,049 RGD:1624291
RGD:1600115
G Swsap1 SWIM-type zinc finger 7 associated protein 1 JBrowse link 8 22,966,752 22,969,280 RGD:1624291
RGD:13792537
G Tonsl tonsoku-like, DNA repair protein JBrowse link 7 117,688,397 117,703,139 RGD:1600115
RGD:1624291
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:1624291
G Wdr48 WD repeat domain 48 JBrowse link 8 128,577,080 128,610,287 RGD:1624291
G Wrn WRN RecQ like helicase JBrowse link 16 62,483,773 62,619,018 RGD:13792537
G Xrcc2 X-ray repair cross complementing 2 JBrowse link 4 5,842,013 5,860,516 RGD:1624291
RGD:13792537
G Xrcc3 X-ray repair cross complementing 3 JBrowse link 6 136,366,917 136,380,751 RGD:1624291
G Yy1 YY1 transcription factor JBrowse link 6 132,702,443 132,726,848 RGD:1624291
G Zfyve26 zinc finger FYVE-type containing 26 JBrowse link 6 102,409,235 102,472,962 RGD:1600115
RGD:1624291
G Zswim7 zinc finger, SWIM-type containing 7 JBrowse link 10 48,587,117 48,599,208 RGD:1624291
RGD:13792537
double-strand break repair via nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyren cell cycle regulator of NHEJ JBrowse link 4 62,391,770 62,397,162 RGD:1624291
RGD:13792537
RGD:1600115
G Dclre1a DNA cross-link repair 1A JBrowse link 1 277,335,792 277,355,701 RGD:13792537
G Dclre1b DNA cross-link repair 1B JBrowse link 2 206,285,085 206,293,599 RGD:13792537
G Dclre1c DNA cross-link repair 1C JBrowse link 17 78,782,512 78,812,140 RGD:13792537
G Dntt DNA nucleotidylexotransferase JBrowse link 1 260,289,626 260,321,174 RGD:13792537
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:1624291
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 10 2,010,140 2,037,953 RGD:1624291
G Kdm2a lysine demethylase 2A JBrowse link 1 219,566,130 219,642,294 RGD:1624291
G Lig1 DNA ligase 1 JBrowse link 1 75,356,212 75,394,757 RGD:1624291
G Lig3 DNA ligase 3 JBrowse link 10 70,134,734 70,158,051 RGD:1624291
G Lig4 DNA ligase 4 JBrowse link 16 85,331,771 85,339,496 RGD:1624291
RGD:13792537
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:1624291
RGD:1600115
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1624291
RGD:13792537
RGD:1600115
G Nhej1 nonhomologous end-joining factor 1 JBrowse link 9 82,230,230 82,327,923 RGD:1600115
RGD:13792537
RGD:1624291
RGD:8553261
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase JBrowse link 7 99,677,295 99,900,765 RGD:1624291
G Paxx PAXX, non-homologous end joining factor JBrowse link 3 2,678,987 2,681,668 RGD:1624291
RGD:13792537
G Pola1 DNA polymerase alpha 1, catalytic subunit JBrowse link X 62,382,604 62,698,830 RGD:1624291
RGD:1600115
G Polb DNA polymerase beta JBrowse link 16 74,237,001 74,260,272 RGD:13792537
G Poll DNA polymerase lambda JBrowse link 1 265,290,337 265,298,847 RGD:1624291
RGD:13792537
RGD:1600115
G Polm DNA polymerase mu JBrowse link 14 86,069,378 86,079,327 RGD:13792537
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:1624291
G Prpf19 pre-mRNA processing factor 19 JBrowse link 1 226,947,065 226,958,147 RGD:1624291
RGD:1600115
G Psmd14 proteasome 26S subunit, non-ATPase 14 JBrowse link 3 47,578,449 47,673,330 RGD:1624291
G Rnf8 ring finger protein 8 JBrowse link 20 8,285,380 8,309,858 RGD:1600115
RGD:1624291
G Setmar SET domain and mariner transposase fusion gene JBrowse link 4 140,092,346 140,104,495 RGD:1624291
G Smarcal1 Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 JBrowse link 9 79,943,775 79,990,230 RGD:1600115
RGD:1624291
G Smc5 structural maintenance of chromosomes 5 JBrowse link 1 240,977,898 241,046,273 RGD:1624291
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link 3 113,160,030 113,259,701 RGD:1624291
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:1624291
G Xrcc4 X-ray repair cross complementing 4 JBrowse link 2 18,674,496 18,927,463 RGD:1624291
RGD:13792537
G Xrcc5 X-ray repair cross complementing 5 JBrowse link 9 79,659,275 79,748,050 RGD:1624291
RGD:13792537
G Xrcc6 X-ray repair cross complementing 6 JBrowse link 7 123,259,881 123,280,613 RGD:1624291
RGD:13792537
double-strand break repair via single-strand annealing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 4 152,429,826 152,451,875 RGD:13792537
double-strand break repair via synthesis-dependent strand annealing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fancm FA complementation group M JBrowse link 6 86,823,195 86,877,067 RGD:13792537
G Xrcc3 X-ray repair cross complementing 3 JBrowse link 6 136,366,917 136,380,751 RGD:13792537
late meiotic recombination nodule assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mcmdc2 minichromosome maintenance domain containing 2 JBrowse link 5 8,973,861 9,039,616 RGD:1624291
RGD:1600115
meiotic DNA double-strand break processing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:13792537
G Spo11 SPO11, initiator of meiotic double stranded breaks JBrowse link 3 170,991,573 171,008,226 RGD:13792537
meiotic DNA double-strand break processing involved in reciprocal meiotic recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brip1 BRCA1 interacting protein C-terminal helicase 1 JBrowse link 10 73,507,009 73,632,742 RGD:1624291
G Six6os1 Six6 opposite strand transcript 1 JBrowse link 6 95,761,718 95,797,314 RGD:1624291
RGD:13792537
meiotic recombination nodule assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mcmdc2 minichromosome maintenance domain containing 2 JBrowse link 5 8,973,861 9,039,616 RGD:1624291
mitochondrial double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:13792537
negative regulation of double-strand break repair term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 JBrowse link 1 222,451,674 222,459,952 RGD:1624291
RGD:1600115
G Rnf169 ring finger protein 169 JBrowse link 1 164,917,069 164,978,061 RGD:1624291
G Trip12 thyroid hormone receptor interactor 12 JBrowse link 9 92,305,059 92,435,388 RGD:1600115
RGD:1624291
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 7
7
76,789,110
76,839,661
76,835,517
76,907,441
RGD:1600115
RGD:1624291
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cgas cyclic GMP-AMP synthase JBrowse link 8 85,789,515 85,804,008 RGD:1624291
RGD:13792537
G Fancb FA complementation group B JBrowse link X 31,124,018 31,140,790 RGD:1624291
RGD:13792537
G Fbh1 F-box DNA helicase 1 JBrowse link 17 70,399,093 70,437,151 RGD:1624291
G Helb DNA helicase B JBrowse link 7 64,860,641 64,888,146 RGD:1624291
RGD:13792537
G Klhl15 kelch-like family member 15 JBrowse link X 63,342,277 63,390,915 RGD:1624291
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link 5 164,943,183 164,956,255 RGD:1624291
G Parpbp PARP1 binding protein JBrowse link 7 28,654,707 28,724,412 RGD:1624291
RGD:1600115
G Polq DNA polymerase theta JBrowse link 11 66,585,860 66,695,369 RGD:1624291
G Radx RPA1 related single stranded DNA binding protein, X-linked JBrowse link X 110,670,037 110,782,420 RGD:1624291
RGD:1600115
G Recql5 RecQ like helicase 5 JBrowse link 10 104,443,735 104,482,889 RGD:1624291
G Rif1 replication timing regulatory factor 1 JBrowse link 3 37,599,540 37,648,818 RGD:1624291
G Rmi2 RecQ mediated genome instability 2 JBrowse link 10 4,904,458 4,910,339 RGD:13792537
G Shld1 shieldin complex subunit 1 JBrowse link 3 125,318,682 125,396,705 RGD:1624291
RGD:13792537
G Shld2 shieldin complex subunit 2 JBrowse link 16 10,570,307 10,661,528 RGD:1624291
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 JBrowse link 9 119,675,750 119,818,620 RGD:1624291
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link 3 113,160,030 113,259,701 RGD:1624291
G Ubqln4 ubiquilin 4 JBrowse link 2 187,915,701 187,931,035 RGD:1624291
negative regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aunip aurora kinase A and ninein interacting protein JBrowse link 5 152,721,799 152,734,577 RGD:1624291
RGD:1600115
G Cyren cell cycle regulator of NHEJ JBrowse link 4 62,391,770 62,397,162 RGD:1624291
RGD:1600115
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:1624291
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
RGD:1600115
G Hsf1 heat shock transcription factor 1 JBrowse link 7 117,538,523 117,565,478 RGD:1624291
G Nudt16l1 nudix hydrolase 16 like 1 JBrowse link 10 10,829,866 10,831,782 RGD:1624291
negative regulation of double-strand break repair via single-strand annealing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ogg1 8-oxoguanine DNA glycosylase JBrowse link 4 145,282,828 145,289,367 RGD:1624291
positive regulation of double-strand break repair term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddx11 DEAD/H-box helicase 11 JBrowse link 9 114,113,642 114,133,908 RGD:1624291
G Fmn2 formin 2 JBrowse link 13 92,569,256 92,887,302 RGD:1624291
G Foxm1 forkhead box M1 JBrowse link 4 161,685,236 161,697,633 RGD:1600115
RGD:1624291
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 1 209,237,255 209,464,189 RGD:1624291
G Nudt16 nudix hydrolase 16 JBrowse link 8 113,673,069 113,675,124 RGD:1624291
G Slf1 SMC5-SMC6 complex localization factor 1 JBrowse link 2 4,095,126 4,195,819 RGD:1624291
G Slf2 SMC5-SMC6 complex localization factor 2 JBrowse link 1 264,670,836 264,733,465 RGD:1624291
G Spidr scaffold protein involved in DNA repair JBrowse link 11 89,009,931 89,260,361 RGD:1624291
G Spire1 spire-type actin nucleation factor 1 JBrowse link 18 63,226,557 63,357,420 RGD:1624291
G Spire2 spire-type actin nucleation factor 2 JBrowse link 19 56,136,904 56,175,500 RGD:1624291
G Timeless timeless circadian regulator JBrowse link 7 2,643,288 2,667,329 RGD:1624291
RGD:1600115
G Wrap53 WD repeat containing, antisense to TP53 JBrowse link 10 56,169,024 56,185,800 RGD:1600115
RGD:1624291
positive regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actr2 actin related protein 2 JBrowse link 14 104,338,486 104,375,840 RGD:1600115
RGD:1624291
G Arid2 AT-rich interaction domain 2 JBrowse link 7 137,680,564 137,798,329 RGD:1600115
RGD:1624291
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:1624291
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:1624291
G Fancb FA complementation group B JBrowse link X 31,124,018 31,140,790 RGD:1624291
RGD:13792537
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:1624291
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component JBrowse link 1 261,191,646 261,229,070 RGD:1624291
G Mrnip MRN complex interacting protein JBrowse link 10 35,680,687 35,704,685 RGD:1624291
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:1600115
RGD:1624291
G Timeless timeless circadian regulator JBrowse link 7 2,643,288 2,667,329 RGD:1600115
RGD:1624291
G Was WASP actin nucleation promoting factor JBrowse link X 15,155,246 15,164,099 RGD:1624291
G Wrap53 WD repeat containing, antisense to TP53 JBrowse link 10 56,169,024 56,185,800 RGD:1600115
RGD:1624291
positive regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dtx3l deltex E3 ubiquitin ligase 3L JBrowse link 11
11
67,758,093
67,768,542
67,767,623
67,772,428
RGD:1624291
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:1600115
RGD:1624291
G Kdm4d lysine demethylase 4D JBrowse link 8 12,968,192 12,993,651 RGD:1624291
G Kmt5b lysine methyltransferase 5B JBrowse link 1 219,000,844 219,050,211 RGD:1624291
RGD:1600115
G Kmt5c lysine methyltransferase 5C JBrowse link 1 72,666,662 72,674,271 RGD:1624291
RGD:1600115
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link 5 164,943,183 164,956,255 RGD:1624291
G Parp3 poly (ADP-ribose) polymerase family, member 3 JBrowse link 8 115,173,440 115,179,543 RGD:1624291
G Parp9 poly (ADP-ribose) polymerase family, member 9 JBrowse link 11 67,724,071 67,758,027 RGD:1624291
G Pnkp polynucleotide kinase 3'-phosphatase JBrowse link 1 100,853,475 100,859,202 RGD:1600115
RGD:1624291
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:1624291
G Rif1 replication timing regulatory factor 1 JBrowse link 3 37,599,540 37,648,818 RGD:1624291
G Setmar SET domain and mariner transposase fusion gene JBrowse link 4 140,092,346 140,104,495 RGD:1624291
G Shld1 shieldin complex subunit 1 JBrowse link 3 125,318,682 125,396,705 RGD:1624291
RGD:13792537
G Shld2 shieldin complex subunit 2 JBrowse link 16 10,570,307 10,661,528 RGD:1624291
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 JBrowse link 9 119,675,750 119,818,620 RGD:1624291
G Top2b DNA topoisomerase II beta JBrowse link 15 10,262,972 10,319,741 RGD:13432143
G Wrap53 WD repeat containing, antisense to TP53 JBrowse link 10 56,169,024 56,185,800 RGD:1600115
RGD:1624291
regulation of DNA double-strand break processing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Helb DNA helicase B JBrowse link 7 64,860,641 64,888,146 RGD:1624291
G Wdr70 WD repeat domain 70 JBrowse link 2 56,944,462 57,196,522 RGD:13792537
regulation of double-strand break repair term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dek DEK proto-oncogene JBrowse link 17 17,965,872 17,987,836 RGD:1624291
RGD:13792537
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
G Trip12 thyroid hormone receptor interactor 12 JBrowse link 9 92,305,059 92,435,388 RGD:13792537
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 7
7
76,789,110
76,839,661
76,835,517
76,907,441
RGD:13792537
regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:1624291
RGD:1600115
G Fign fidgetin, microtubule severing factor JBrowse link 3 49,992,250 50,120,601 RGD:13792537
G Fignl1 fidgetin-like 1 JBrowse link 14 91,895,902 91,904,474 RGD:1624291
RGD:13792537
RGD:1600115
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:1624291
G Ppp4c protein phosphatase 4, catalytic subunit JBrowse link 1 198,219,012 198,225,775 RGD:1600115
RGD:1624291
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 JBrowse link 4 133,285,552 133,323,755 RGD:1624291
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:1624291
G Rad51ap1 RAD51 associated protein 1 JBrowse link 4 159,469,803 159,482,869 RGD:1624291
G Rpa2 replication protein A2 JBrowse link 5 150,957,041 150,967,597 RGD:1624291
RGD:1600115
G Rtel1 regulator of telomere elongation helicase 1 JBrowse link 3 176,818,012 176,856,531 RGD:1624291
RGD:13792537
RGD:1600115
G Setd2 SET domain containing 2, histone lysine methyltransferase JBrowse link 8 118,802,478 118,888,224 RGD:1624291
G Sirt6 sirtuin 6 JBrowse link 7 10,937,622 10,943,048 RGD:1624291
G Spidr scaffold protein involved in DNA repair JBrowse link 11 89,009,931 89,260,361 RGD:1624291
G Terf2ip TERF2 interacting protein JBrowse link 19 44,231,317 44,238,406 RGD:1624291
RGD:1600115
G Tex15 testis expressed 15, meiosis and synapsis associated JBrowse link 16 62,313,284 62,373,288 RGD:1624291
G Usp51 ubiquitin specific peptidase 51 JBrowse link X 19,268,352 19,273,753 RGD:1624291
G Zfp365 zinc finger protein 365 JBrowse link 20 22,060,160 22,083,766 RGD:1624291
RGD:1600115
regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actr2 actin related protein 2 JBrowse link 14 104,338,486 104,375,840 RGD:1600115
RGD:1624291
G Dek DEK proto-oncogene JBrowse link 17 17,965,872 17,987,836 RGD:1624291
G Mrnip MRN complex interacting protein JBrowse link 10 35,680,687 35,704,685 RGD:1624291
G Nsd2 nuclear receptor binding SET domain protein 2 JBrowse link 14 82,119,210 82,196,501 RGD:1624291
G Pot1 protection of telomeres 1 JBrowse link 4 51,888,632 51,946,764 RGD:1624291
G Sirt7 sirtuin 7 JBrowse link 10 109,796,046 109,802,821 RGD:1600115
RGD:1624291
G Usp51 ubiquitin specific peptidase 51 JBrowse link X 19,268,352 19,273,753 RGD:1624291
G Was WASP actin nucleation promoting factor JBrowse link X 15,155,246 15,164,099 RGD:1624291
replication-born double-strand break repair via sister chromatid exchange term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:1624291
G Fancb FA complementation group B JBrowse link X 31,124,018 31,140,790 RGD:1624291
RGD:13792537
G Nipbl NIPBL, cohesin loading factor JBrowse link 2 57,508,830 57,676,197 RGD:13792537
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:1624291
G Recql5 RecQ like helicase 5 JBrowse link 10 104,443,735 104,482,889 RGD:1624291
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    metabolic process 11638
      cellular metabolic process 10639
        cellular macromolecule metabolic process 8177
          DNA metabolic process 885
            DNA repair 473
              double-strand break repair 239
                DNA double-strand break processing + 19
                double-strand break repair involved in meiotic recombination 6
                double-strand break repair via homologous recombination + 133
                double-strand break repair via nonhomologous end joining + 65
                double-strand break repair via single-strand annealing + 7
                mitochondrial double-strand break repair + 1
                negative regulation of double-strand break repair + 29
                positive regulation of double-strand break repair + 38
                regulation of double-strand break repair + 82
Path 2
Term Annotations click to browse term
  biological_process 19439
    metabolic process 11638
      cellular metabolic process 10639
        cellular aromatic compound metabolic process 5503
          nucleobase-containing compound metabolic process 5274
            nucleic acid metabolic process 4784
              DNA metabolic process 885
                DNA repair 473
                  double-strand break repair 239
                    DNA double-strand break processing + 19
                    double-strand break repair involved in meiotic recombination 6
                    double-strand break repair via homologous recombination + 133
                    double-strand break repair via nonhomologous end joining + 65
                    double-strand break repair via single-strand annealing + 7
                    mitochondrial double-strand break repair + 1
                    negative regulation of double-strand break repair + 29
                    positive regulation of double-strand break repair + 38
                    regulation of double-strand break repair + 82
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.