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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chagas Cardiomyopathy
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Accession:DOID:9004422 term browser browse the term
Definition:A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
Synonyms:exact_synonym: Cardiovascular Trypanosomiasis;   Myocarditis, Chagas
 primary_id: MESH:D002598;   RDO:0005179
 xref: EFO:0005529


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Chagas Cardiomyopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 C-X-C motif chemokine ligand 15 disease_progression ISO DNA:SNP:promoter:g.-251A>T (rs4073) (human) RGD PMID:22537745 RGD:39939013 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO DNA:polymorphism:exon (human) RGD PMID:19811437 RGD:5147589 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:24055715 RGD:7364866 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 IMP RGD PMID:28356392 RGD:39457935 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 severity ISO RGD PMID:26745156 RGD:11076757 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Pcna proliferating cell nuclear antigen ISO protein:increased expression:myocardium: RGD PMID:12435130 RGD:10448990 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma disease_progression IEP
IMP
ISO		 mRNA:increased expression:heart (mouse)
mRNA:increased expression:heart (human)		 RGD PMID:29666415 PMID:29666415 PMID:29666415 RGD:38599151, RGD:38599151, RGD:38599151 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16223
    disease of anatomical entity 15842
      cardiovascular system disease 4691
        heart disease 3365
          cardiomyopathy 1450
            Chagas Cardiomyopathy 7
Path 2
Term Annotations click to browse term
  disease 16223
    disease by infectious agent 2237
      parasitic infectious disease 322
        parasitic protozoa infectious disease 170
          Euglenozoa Infections 87
            trypanosomiasis 30
              Chagas disease 17
                Chagas Cardiomyopathy 7
paths to the root