RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Synonyms:
exact_synonym:
AIDS Encephalopathies; AIDS Encephalopathy; AIDS Related Dementia Complex; AIDS dementia; Acquired-Immune Deficiency Syndrome Dementia Complex; HAND; HIV 1 Associated Cognitive Motor Complex; HIV 1 Cognitive and Motor Complex; HIV Associated Cognitive Motor Complex; HIV Dementia; HIV Dementias; HIV Encephalopathies; HIV Encephalopathy; HIV-associated neurocognitive disorders