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scrapie - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:scrapie
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Accession:DOID:5434 term browser browse the term
Definition:A fatal disease of the nervous system in sheep and goats, characterized by pruritus, debility, and locomotor incoordination. It is caused by proteinaceous infectious particles called PRIONS.
Synonyms:exact_synonym: Rida
 primary_id: MESH:D012608
 xref: EFO:1001168
For additional species annotation, visit the Alliance of Genome Resources.

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scrapie term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23349890 NCBI chr20:2,112,819...2,304,063
Ensembl chr20:2,117,982...2,304,027 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator ISO RGD PMID:27921253 RGD:13782156 NCBI chr 6:42,186,028...42,193,105 JBrowse link
G CASP3 caspase 3 ISO RGD PMID:27921253 RGD:13782156 NCBI chr 7:130,589,592...130,610,845
Ensembl chr 7:130,591,166...130,610,899 		JBrowse link
G CASP9 caspase 9 ISO RGD PMID:27921253 RGD:13782156 NCBI chr20:116,772,819...116,798,402
Ensembl chr20:116,772,155...116,798,930 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO RGD PMID:22787236 RGD:13782158 NCBI chr16:29,351,214...29,361,317 JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO RGD PMID:18396336 RGD:5688145 NCBI chr22:7,634,205...7,641,380 JBrowse link
G CR2 complement C3d receptor 2 ISO RGD PMID:29202042 RGD:127285805 NCBI chr25:21,914,690...21,954,244
Ensembl chr25:21,919,393...21,953,659 		JBrowse link
G JAK2 Janus kinase 2 ISO protein:increased expression:brain RGD PMID:17897356 RGD:6483034 NCBI chr12:74,421,243...74,566,766
Ensembl chr12:74,421,016...74,566,710 		JBrowse link
G NEGR1 neuronal growth regulator 1 ISO RGD PMID:29087046 RGD:40886276 NCBI chr20:60,848,712...61,731,563 JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 ISO protein:increased expression:brain: RGD PMID:15772339 RGD:9999196 NCBI chr26:39,273,982...39,300,170
Ensembl chr26:39,272,997...39,349,966 		JBrowse link
G PRNP prion protein (Kanno blood group) onset ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:11701772 PMID:18717736 PMID:19486493 PMID:21533749 PMID:29157304 RGD:15045596 NCBI chr 2:33,368,020...33,384,556
Ensembl chr 2:33,369,629...33,370,366 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 susceptibility ISO RGD PMID:16730863 RGD:38676483 NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616 		JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11701772 NCBI chr 2:60,461,219...60,472,999 JBrowse link
G SPP1 secreted phosphoprotein 1 ISO RGD PMID:16412998 RGD:1581331 NCBI chr 7:36,337,165...36,344,927
Ensembl chr 7:36,338,386...36,344,407 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO protein:increased expression:brain RGD PMID:17897356 RGD:6483034 NCBI chr10:76,492,859...76,537,689
Ensembl chr10:76,492,533...76,533,393 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO protein:increased tyrosine phosphorylation:brain, nucleus RGD PMID:17897356 RGD:6483034 NCBI chr16:63,877,884...63,957,894
Ensembl chr16:63,922,862...63,957,984 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15412
    Animal Diseases 1320
      Sheep Diseases 16
        scrapie 16
Path 2
Term Annotations click to browse term
  disease 15412
    disease of anatomical entity 15076
      nervous system disease 13225
        central nervous system disease 11812
          neurodegenerative disease 4835
            prion disease 103
              scrapie 16
paths to the root