RGD Reference Report - Unaltered susceptibility to scrapie in serotonin transporter deficient mice. - Rat Genome Database

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Unaltered susceptibility to scrapie in serotonin transporter deficient mice.

Authors: Mössner, Rainald  Yun, Seong-Wook  Lesch, Klaus-Peter  Gerlach, Manfred  Klein, Michael A  Riederer, Peter 
Citation: Mössner R, etal., Neurochem Int. 2006 Oct;49(5):454-8. doi: 10.1016/j.neuint.2006.03.008. Epub 2006 May 30.
RGD ID: 38676483
Pubmed: PMID:16730863   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuint.2006.03.008   (Journal Full-text)

The serotonergic system has been hypothesized to play an important role in prion diseases. Specifically, hyperactivity of the serotonergic system in prion diseases is suggested by an increase in the turnover rate of the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) in human and experimental prion diseases. The 5-HT transporter (5-HTT) determines the duration of serotonergic neurotransmission by way of reuptake of 5-HT from the extracellular space. 5-HTT availability is reduced in brains of patients with the human prion disease familial fatal insomnia. To further clarify a possible role of the 5-HTT in prion diseases we investigated whether mice lacking the 5-HTT display an altered susceptibility to experimental scrapie infection. Surprisingly, 5-HTT knockout mice developed mouse scrapie in a time course similar to wildtype control mice with accumulation of the pathological prion protein, PrP(Sc) and with typical pathological hallmarks of the disease. These findings argue against a major role of the 5-HTT in the pathogenesis of prion diseases in mice.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SLC6A4Humanscrapie susceptibilityISOSlc6a4 (Mus musculus) RGD 
Slc6a4Ratscrapie susceptibilityISOSlc6a4 (Mus musculus) RGD 
Slc6a4Mousescrapie susceptibilityIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc6a4  (solute carrier family 6 member 4)

Genes (Mus musculus)
Slc6a4  (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Genes (Homo sapiens)
SLC6A4  (solute carrier family 6 member 4)


Additional Information