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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:neurodegenerative disease
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Accession:DOID:1289 term browser browse the term
Definition:A central nervous system disease that results in the progressive deterioration of function or structure of neurons. (DO)
Synonyms:exact_synonym: Degenerative Neurologic Disease;   Degenerative Neurologic Disorder;   Degenerative Neurologic Disorders;   Nervous System Degenerative Diseases;   Neurodegenerative Diseases;   Neurodegenerative Disorder;   Neurodegenerative Disorders;   Neurologic Degenerative Condition;   central nervous system degenerative diseases;   degenerative disease;   degenerative neurologic diseases;   neurologic degenerative conditions;   spinal cord degenerative diseases
 narrow_synonym: Neurodegenerative illness progressing to crippling dystonia and death with relentless cerebral atrophy;   progressive neurodegenerative disease;   severe cystic degeneration of the brain
 primary_id: MESH:D019636
 xref: ICD10CM:G31.9;   NCI:C27090
For additional species annotation, visit the Alliance of Genome Resources.



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  • Term paths to the root
    Path 1
    Term Annotations click to browse term
      disease 18030
        disease of anatomical entity 17410
          nervous system disease 13079
            neurodegenerative disease 3871
              BRAIN ABNORMALITIES, NEURODEGENERATION, AND DYSOSTEOSCLEROSIS 1
              Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy 2
              Childhood-Onset Neurodegeneration with Brain Atrophy 1
              Childhood-Onset Neurodegeneration with Cerebellar Atrophy 1
              Childhood-onset Neurodegeneration with Ataxia, Tremor, Optic Atrophy, and Cognitive Decline 1
              Chronic Traumatic Encephalopathy 0
              FINCA Syndrome 1
              Feigenbaum Bergeron Richardson Syndrome 0
              Huntington's disease-like 2 1
              Idiopathic Basal Ganglia Calcification 1 11
              Idiopathic Basal Ganglia Calcification 6 1
              Idiopathic Basal Ganglia Calcification 7 1
              LEUKOENCEPHALOPATHY, DEVELOPMENTAL DELAY, AND EPISODIC NEUROLOGIC REGRESSION SYNDROME 1
              NEURODEGENERATION, EARLY-ONSET, WITH CHOREOATHETOID MOVEMENTS AND MICROCYTIC ANEMIA 1
              NEURODEGENERATION, INFANTILE-ONSET, BIOTIN-RESPONSIVE 1
              Nervous System Heredodegenerative Disorders + 2365
              Nervous System Paraneoplastic Syndromes + 19
              Neurodegeneration with Ataxia and Late-Onset Optic Atrophy 1
              Neuronal Intranuclear Inclusion Disease 1
              PEHO syndrome 4
              Radiation Sensitivity Chromosome Instability Syndrome, Autosomal Dominant 0
              Recurrent Metabolic Crises with Variable Encephalomyopathic Features and Neurologic Regression 1
              SEIZURES, EARLY-ONSET, WITH NEURODEGENERATION AND BRAIN CALCIFICATIONS 1
              Spastic Pseudosclerosis 0
              Subacute Combined Degeneration 2
              TDP-43 Proteinopathies + 357
              aceruloplasminemia 30
              agenesis of the corpus callosum with peripheral neuropathy 5
              demyelinating disease + 475
              eye degenerative disease + 527
              hereditary ataxia + 396
              motor neuron disease + 490
              multiple system atrophy + 40
              myoclonic cerebellar dyssynergia + 0
              neurodegeneration with brain iron accumulation + 52
              olivopontocerebellar atrophy + 21
              plexopathy 0
              pontocerebellar hypoplasia + 28
              postpoliomyelitis syndrome 0
              primary cerebellar degeneration + 379
              prion disease + 55
              secondary Parkinson disease + 16
              stress-induced childhood-onset neurodegeneration with variable ataxia and seizures 1
              synucleinopathy + 349
              tauopathy + 505
    Path 2
    Term Annotations click to browse term
      disease 18030
        disease of anatomical entity 17410
          nervous system disease 13079
            central nervous system disease 11253
              neurodegenerative disease 3871
                BRAIN ABNORMALITIES, NEURODEGENERATION, AND DYSOSTEOSCLEROSIS 1
                Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy 2
                Childhood-Onset Neurodegeneration with Brain Atrophy 1
                Childhood-Onset Neurodegeneration with Cerebellar Atrophy 1
                Childhood-onset Neurodegeneration with Ataxia, Tremor, Optic Atrophy, and Cognitive Decline 1
                Chronic Traumatic Encephalopathy 0
                FINCA Syndrome 1
                Feigenbaum Bergeron Richardson Syndrome 0
                Huntington's disease-like 2 1
                Idiopathic Basal Ganglia Calcification 1 11
                Idiopathic Basal Ganglia Calcification 6 1
                Idiopathic Basal Ganglia Calcification 7 1
                LEUKOENCEPHALOPATHY, DEVELOPMENTAL DELAY, AND EPISODIC NEUROLOGIC REGRESSION SYNDROME 1
                NEURODEGENERATION, EARLY-ONSET, WITH CHOREOATHETOID MOVEMENTS AND MICROCYTIC ANEMIA 1
                NEURODEGENERATION, INFANTILE-ONSET, BIOTIN-RESPONSIVE 1
                Nervous System Heredodegenerative Disorders + 2365
                Nervous System Paraneoplastic Syndromes + 19
                Neurodegeneration with Ataxia and Late-Onset Optic Atrophy 1
                Neuronal Intranuclear Inclusion Disease 1
                PEHO syndrome 4
                Radiation Sensitivity Chromosome Instability Syndrome, Autosomal Dominant 0
                Recurrent Metabolic Crises with Variable Encephalomyopathic Features and Neurologic Regression 1
                SEIZURES, EARLY-ONSET, WITH NEURODEGENERATION AND BRAIN CALCIFICATIONS 1
                Spastic Pseudosclerosis 0
                Subacute Combined Degeneration 2
                TDP-43 Proteinopathies + 357
                aceruloplasminemia 30
                agenesis of the corpus callosum with peripheral neuropathy 5
                demyelinating disease + 475
                eye degenerative disease + 527
                hereditary ataxia + 396
                motor neuron disease + 490
                multiple system atrophy + 40
                myoclonic cerebellar dyssynergia + 0
                neurodegeneration with brain iron accumulation + 52
                olivopontocerebellar atrophy + 21
                plexopathy 0
                pontocerebellar hypoplasia + 28
                postpoliomyelitis syndrome 0
                primary cerebellar degeneration + 379
                prion disease + 55
                secondary Parkinson disease + 16
                stress-induced childhood-onset neurodegeneration with variable ataxia and seizures 1
                synucleinopathy + 349
                tauopathy + 505
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