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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:neurodegenerative disease
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Accession:DOID:1289 term browser browse the term
Definition:A central nervous system disease that results in the progressive deterioration of function or structure of neurons. (DO)
Synonyms:exact_synonym: Degenerative Diseases, Central Nervous System;   Degenerative Neurologic Disease;   Degenerative Neurologic Diseases;   Degenerative Neurologic Disorder;   Degenerative Neurologic Disorders;   Nervous System Degenerative Diseases;   Neurodegenerative Diseases;   Neurodegenerative Disorder;   Neurodegenerative Disorders;   Neurologic Degenerative Condition;   Neurologic Degenerative Conditions;   degenerative disease;   spinal cord degenerative diseases
 narrow_synonym: Neurodegenerative illness progressing to crippling dystonia and death with relentless cerebral atrophy;   PROGRESSIVE NEURODEGENERATIVE DISEASE;   severe cystic degeneration of the brain
 primary_id: MESH:D019636
 xref: ICD10CM:G31.9;   NCI:C27090
For additional species annotation, visit the Alliance of Genome Resources.


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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16058
    disease of anatomical entity 15305
      nervous system disease 10879
        neurodegenerative disease 3191
          BRAIN ABNORMALITIES, NEURODEGENERATION, AND DYSOSTEOSCLEROSIS 1
          Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy 1
          Childhood-Onset Neurodegeneration with Brain Atrophy 1
          Childhood-Onset Neurodegeneration with Cerebellar Atrophy 1
          Childhood-onset Neurodegeneration with Ataxia, Tremor, Optic Atrophy, and Cognitive Decline 1
          Chronic Traumatic Encephalopathy 0
          FINCA Syndrome 1
          Feigenbaum Bergeron Richardson Syndrome 0
          Huntington's disease-like 2 1
          Idiopathic Basal Ganglia Calcification 1 10
          Idiopathic Basal Ganglia Calcification 6 1
          Idiopathic Basal Ganglia Calcification 7 1
          LEUKOENCEPHALOPATHY, DEVELOPMENTAL DELAY, AND EPISODIC NEUROLOGIC REGRESSION SYNDROME 1
          NEURODEGENERATION, EARLY-ONSET, WITH CHOREOATHETOID MOVEMENTS AND MICROCYTIC ANEMIA 1
          Nervous System Heredodegenerative Disorders + 1950
          Nervous System Paraneoplastic Syndromes + 18
          Neurodevelopmental Disorder with Epilepsy, Spasticity, and Brain Atrophy 1
          Neuronal Intranuclear Inclusion Disease 1
          PEHO syndrome 4
          Pick's disease 10
          Radiation Sensitivity Chromosome Instability Syndrome, Autosomal Dominant 0
          Recurrent Metabolic Crises with Variable Encephalomyopathic Features and Neurologic Regression 1
          SEIZURES, EARLY-ONSET, WITH NEURODEGENERATION AND BRAIN CALCIFICATIONS 1
          Spastic Pseudosclerosis 0
          Subacute Combined Degeneration 2
          TDP-43 Proteinopathies + 259
          aceruloplasminemia 3
          agenesis of the corpus callosum with peripheral neuropathy 3
          demyelinating disease + 405
          eye degenerative disease + 468
          eyelid degenerative disease + 0
          hereditary ataxia + 282
          motor neuron disease + 370
          multiple system atrophy + 29
          myoclonic cerebellar dyssynergia + 0
          neurodegeneration with brain iron accumulation + 14
          olivopontocerebellar atrophy + 10
          plexopathy 0
          pontocerebellar hypoplasia + 23
          postpoliomyelitis syndrome 0
          primary cerebellar degeneration + 306
          prion disease + 42
          secondary Parkinson disease + 13
          stress-induced childhood-onset neurodegeneration with variable ataxia and seizures 1
          synucleinopathy + 274
          tauopathy + 489
Path 2
Term Annotations click to browse term
  disease 16058
    disease of anatomical entity 15305
      nervous system disease 10879
        central nervous system disease 9021
          neurodegenerative disease 3191
            BRAIN ABNORMALITIES, NEURODEGENERATION, AND DYSOSTEOSCLEROSIS 1
            Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy 1
            Childhood-Onset Neurodegeneration with Brain Atrophy 1
            Childhood-Onset Neurodegeneration with Cerebellar Atrophy 1
            Childhood-onset Neurodegeneration with Ataxia, Tremor, Optic Atrophy, and Cognitive Decline 1
            Chronic Traumatic Encephalopathy 0
            FINCA Syndrome 1
            Feigenbaum Bergeron Richardson Syndrome 0
            Huntington's disease-like 2 1
            Idiopathic Basal Ganglia Calcification 1 10
            Idiopathic Basal Ganglia Calcification 6 1
            Idiopathic Basal Ganglia Calcification 7 1
            LEUKOENCEPHALOPATHY, DEVELOPMENTAL DELAY, AND EPISODIC NEUROLOGIC REGRESSION SYNDROME 1
            NEURODEGENERATION, EARLY-ONSET, WITH CHOREOATHETOID MOVEMENTS AND MICROCYTIC ANEMIA 1
            Nervous System Heredodegenerative Disorders + 1950
            Nervous System Paraneoplastic Syndromes + 18
            Neurodevelopmental Disorder with Epilepsy, Spasticity, and Brain Atrophy 1
            Neuronal Intranuclear Inclusion Disease 1
            PEHO syndrome 4
            Pick's disease 10
            Radiation Sensitivity Chromosome Instability Syndrome, Autosomal Dominant 0
            Recurrent Metabolic Crises with Variable Encephalomyopathic Features and Neurologic Regression 1
            SEIZURES, EARLY-ONSET, WITH NEURODEGENERATION AND BRAIN CALCIFICATIONS 1
            Spastic Pseudosclerosis 0
            Subacute Combined Degeneration 2
            TDP-43 Proteinopathies + 259
            aceruloplasminemia 3
            agenesis of the corpus callosum with peripheral neuropathy 3
            demyelinating disease + 405
            eye degenerative disease + 468
            eyelid degenerative disease + 0
            hereditary ataxia + 282
            motor neuron disease + 370
            multiple system atrophy + 29
            myoclonic cerebellar dyssynergia + 0
            neurodegeneration with brain iron accumulation + 14
            olivopontocerebellar atrophy + 10
            plexopathy 0
            pontocerebellar hypoplasia + 23
            postpoliomyelitis syndrome 0
            primary cerebellar degeneration + 306
            prion disease + 42
            secondary Parkinson disease + 13
            stress-induced childhood-onset neurodegeneration with variable ataxia and seizures 1
            synucleinopathy + 274
            tauopathy + 489
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.