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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:taraxasterol
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Accession:CHEBI:9401 term browser browse the term
Definition:A pentacyclic triterpenoid that is taraxastane with a beta-hydroxy group at position 3.
Synonyms:exact_synonym: (3beta,18alpha,19alpha)-urs-20(30)-en-3-ol
 related_synonym: Formula=C30H50O;   InChI=1S/C30H50O/c1-19-11-14-27(5)17-18-29(7)21(25(27)20(19)2)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21-,22+,23-,24+,25-,27-,28+,29-,30-/m1/s1;   InChIKey=XWMMEBCFHUKHEX-ZJJHUPNDSA-N;   SMILES=C[C@H]1[C@@H]2[C@H]3CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C)CCC1=C;   alpha-lactucerol;   isolactucerol;   taraxasterin
 xref: CAS:1059-14-9;   HMDB:HMDB0035920;   KEGG:C08636;   KNApSAcK:C00003757;   LIPID_MAPS_instance:LMPR0106180006
 xref_mesh: MESH:C079988
 xref: MetaCyc:CPD-6949;   PMID:10408235;   PMID:15640948;   PMID:22366673;   PMID:22608078;   PMID:23148482


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taraxasterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO taraxasterol results in decreased phosphorylation of AKT1 protein CTD PMID:35128947 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO taraxasterol results in increased cleavage of CASP3 protein CTD PMID:35128947 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO taraxasterol results in increased expression of CDH1 protein CTD PMID:35128947 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO taraxasterol results in decreased expression of CDH2 protein CTD PMID:35128947 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Ctnna1 catenin alpha 1 increases expression ISO taraxasterol results in increased expression of CTNNA1 protein CTD PMID:35128947 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO taraxasterol results in increased cleavage of PARP1 protein CTD PMID:35128947 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation ISO taraxasterol results in decreased phosphorylation of PIK3R1 protein CTD PMID:35128947 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Vim vimentin decreases expression ISO taraxasterol results in decreased expression of VIM protein CTD PMID:35128947 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        anti-inflammatory agent 16580
          taraxasterol 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            organic hydride 18669
                              organic fundamental parent 18669
                                hydrocarbon 18415
                                  terpene 14057
                                    triterpene 1206
                                      triterpenoid 1202
                                        pentacyclic triterpenoid 467
                                          taraxasterol 8
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