CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: lasalocid
Accession: CHEBI:92181
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Definition: A polyether antibiotic used for prevention and treatment of coccidiosis in poultry.
Synonyms: exact_synonym: (1S,9S)-1,5:6,9-dianhydro-9-[(3R,5S,6S,7R)-9-(2-carboxy-3-hydroxy-4-methylphenyl)-6-hydroxy-5,7-dimethyl-4-oxononan-3-yl]-3,4,7,8-tetradeoxy-6-ethyl-2-C-ethyl-1,8-dimethyl-D-galacto-nonitol
related_synonym: 6-[(3R,4S,5S,7R)-7-{(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-3-methyltetrahydrofuran-2-yl}-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methylbenzoic acid; Formula=C34H54O8; InChI=1S/C34H54O8/c1-9-25(31-21(6)18-34(11-3,42-31)26-16-17-33(40,10-2)23(8)41-26)30(37)22(7)28(35)19(4)12-14-24-15-13-20(5)29(36)27(24)32(38)39/h13,15,19,21-23,25-26,28,31,35-36,40H,9-12,14,16-18H2,1-8H3,(H,38,39)/t19-,21+,22+,23+,25+,26-,28+,31+,33-,34+/m1/s1; InChIKey=BBMULGJBVDDDNI-OWKLGTHSSA-N; Ro 2-2985; SMILES=[H][C@@]1(O[C@@](CC)(C[C@@H]1C)[C@@]1([H])CC[C@](O)(CC)[C@H](C)O1)[C@@H](CC)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCC1=C(C(O)=O)C(O)=C(C)C=C1; X 537A; antibiotic X 537A; ionophore X 537A; lasalocid A; lasalocide; lasalocido; lasalocidum
xref: CAS:25999-31-9; DrugBank:DB11423; KEGG:D04671; LINCS:LSM-2214; LIPID_MAPS_instance:LMPK09000002
xref_mesh: MESH:D007832
xref: PDBeChem:LSD; PMCID:PMC6663702; PMID:1705820; PMID:25364932; PMID:25535803; PMID:25556006; PMID:26054429; PMID:26812337; PMID:27580396; PMID:28178613; PMID:28470877; PMID:28956164; PMID:30191481; PMID:30973080; PMID:31864181; PMID:31906353; PMID:32069059; PMID:32228806; PMID:32625606; PMID:32738374; PMID:32774509; Wikipedia:Lasalocid
cyclic_relationship: is_conjugate_acid_of CHEBI:156364
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Actb
actin, beta
increases expression
ISO
Lasalocid results in increased expression of ACTB protein
CTD
PMID:37788135
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Anxa1
annexin A1
increases expression
ISO
Lasalocid results in increased expression of ANXA1 protein
CTD
PMID:37788135
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Anxa2
annexin A2
increases expression
ISO
Lasalocid results in increased expression of ANXA2 protein
CTD
PMID:37788135
NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
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Dsp
desmoplakin
increases expression
ISO
Lasalocid results in increased expression of DSP protein
CTD
PMID:37788135
NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800
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Hnrnpa1
heterogeneous nuclear ribonucleoprotein A1
increases expression
ISO
Lasalocid results in increased expression of HNRNPA1 protein
CTD
PMID:37788135
NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
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Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
increases expression
ISO
Lasalocid results in increased expression of HNRNPA2B1 protein
CTD
PMID:37788135
NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
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Hspb1
heat shock protein family B (small) member 1
increases expression
ISO
Lasalocid results in increased expression of HSPB1 protein
CTD
PMID:37788135
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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Ivl
involucrin
increases expression
ISO
Lasalocid results in increased expression of IVL protein
CTD
PMID:37788135
NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
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Jup
junction plakoglobin
increases expression
ISO
Lasalocid results in increased expression of JUP protein
CTD
PMID:37788135
NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057
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Krt5
keratin 5
increases expression
ISO
Lasalocid results in increased expression of KRT5 protein
CTD
PMID:37788135
NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850
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Mapt
microtubule-associated protein tau
decreases expression
ISO
Lasalocid results in decreased expression of MAPT protein
CTD
PMID:16930453
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Pkp1
plakophilin 1
increases expression
ISO
Lasalocid results in increased expression of PKP1 protein
CTD
PMID:37788135
NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465
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Ppl
periplakin
increases expression
ISO
Lasalocid results in increased expression of PPL protein
CTD
PMID:37788135
NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575
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S100a10
S100 calcium binding protein A10
increases expression
ISO
Lasalocid results in increased expression of S100A10 protein
CTD
PMID:37788135
NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
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S100a11
S100 calcium binding protein A11
increases expression
ISO
Lasalocid results in increased expression of S100A11 protein
CTD
PMID:37788135
NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044
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S100a16
S100 calcium binding protein A16
increases expression
ISO
Lasalocid results in increased expression of S100A16 protein
CTD
PMID:37788135
NCBI chr 2:176,016,405...176,022,117
Ensembl chr 2:176,016,268...176,022,117
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Serpinb2
serpin family B member 2
increases expression
ISO
Lasalocid results in increased expression of SERPINB2 protein
CTD
PMID:37788135
NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
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Sprr1a
small proline-rich protein 1A
increases expression
ISO
Lasalocid results in increased expression of SPRR1A protein
CTD
PMID:37788135
NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063
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Sprr1b
small proline-rich protein 1B
increases expression
ISO
Lasalocid results in increased expression of SPRR1B protein
CTD
PMID:37788135
NCBI chr 2:178,008,844...178,010,742
Ensembl chr 2:178,009,130...178,009,567
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Sprr2d
small proline-rich protein 2D
increases expression
ISO
Lasalocid results in increased expression of SPRR2D protein
CTD
PMID:37788135
NCBI chr 2:177,870,082...177,870,679
Ensembl chr 2:177,870,434...177,870,679
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