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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,3,4,3',4'-Pentachlorobiphenyl
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Accession:CHEBI:81518 term browser browse the term
Definition:A pentachlorobiphenyl that has formula C12H5Cl5.
Synonyms:related_synonym: Formula=C12H5Cl5;   InChI=1S/C12H5Cl5/c13-8-3-1-6(5-10(8)15)7-2-4-9(14)12(17)11(7)16/h1-5H;   InChIKey=WIDHRBRBACOVOY-UHFFFAOYSA-N;   PCB 105;   SMILES=Clc1ccc(cc1Cl)-c1ccc(Cl)c(Cl)c1Cl
 xref: CAS:32598-14-4;   KEGG:C18116
 xref_mesh: MESH:C067940


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2,3,4,3',4'-Pentachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions		 ISO
EXP		 2,3,3',4,4'-pentachlorobiphenyl results in increased activity of AHR protein
2,3,3',4,4'-pentachlorobiphenyl affects the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; 2,3,3',4,4'-pentachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]
2,3,3',4,4'-pentachlorobiphenyl binds to and results in increased activity of AHR protein		 CTD PMID:10448124 PMID:12850102 PMID:20435555 PMID:20961953 PMID:25654323 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression		 ISO
EXP		 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of CYP1A1 protein
2,3,3',4,4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA
2,3,3',4,4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA; 2,3,3',4,4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein		 CTD PMID:10986007 PMID:16750337 PMID:18493746 PMID:25654323 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions
increases activity
decreases response to substance		 ISO
EXP		 2,3,3',4,4'-pentachlorobiphenyl results in decreased activity of CYP1A2 protein
2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
2,3,3',4,4'-pentachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of CYP1A2 protein
CYP1A2 results in decreased susceptibility to 2,3,3',4,4'-pentachlorobiphenyl		 CTD PMID:10986007 PMID:15659567 PMID:18493746 PMID:20961953 PMID:21571617 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP 2,3,3',4,4'-pentachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:25654323 PMID:29738842 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases response to substance EXP CYP2B1 protein results in increased susceptibility to 2,3,3',4,4'-pentachlorobiphenyl CTD PMID:10640525 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects response to substance ISO CYP2B6 gene SNP affects the susceptibility to 2,3,3',4,4'-pentachlorobiphenyl CTD PMID:25839716 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity		 ISO 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Androstenols results in decreased activity of NR1I3 protein]
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of NR1I3 protein		 CTD PMID:19746742 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions
increases mutagenesis		 ISO 1,2-dichloroethylene inhibits the reaction [2,3,3',4,4'-pentachlorobiphenyl results in increased mutagenesis of PIGA gene] CTD PMID:32199159 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804 		JBrowse link
G Serpina7 serpin family A member 7 decreases expression ISO 2,3,3',4,4'-pentachlorobiphenyl results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO 2,3,3',4,4'-pentachlorobiphenyl affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      chemical role 19451
        environmental contaminant 18857
          persistent organic pollutant 16692
            polychlorobiphenyl 6022
              pentachlorobiphenyl 2684
                2,3,4,3',4'-Pentachlorobiphenyl 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    main group molecular entity 19789
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19120
                            organic hydride 18689
                              organic fundamental parent 18689
                                hydrocarbon 18435
                                  halohydrocarbon 15712
                                    haloarene 6412
                                      chloroarene 6024
                                        chlorobiphenyl 6024
                                          polychlorobiphenyl 6022
                                            pentachlorobiphenyl 2684
                                              2,3,4,3',4'-Pentachlorobiphenyl 11
paths to the root