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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:81518
Term: 2,3,4,3',4'-Pentachlorobiphenyl
Definition: A pentachlorobiphenyl that has formula C12H5Cl5.
Chemical ID: MESH:C067940
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahrincreases activityEXP 6480464CTD2,3,3',4,4'-pentachlorobiphenyl results in increased activity of AHR proteinPMID:25654323
Ahrmultiple interactionsEXP 6480464CTD2,3,3',4,4'-pentachlorobiphenyl binds to and results in increased activity of AHR proteinPMID:12850102
Ahrincreases activityISOAhr (Mus musculus)6480464CTD2,3,3',4,4'-pentachlorobiphenyl results in increased activity of AHR proteinPMID:20435555 PMID:25654323
Ahrincreases activityISOAHR (Homo sapiens)6480464CTD2,3,3',4,4'-pentachlorobiphenyl results in increased activity of AHR proteinPMID:10448124
Ahrmultiple interactionsISOAhr (Mus musculus)6480464CTD2,3,3',4,4'-pentachlorobiphenyl affects the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; 2,3,3',4,4'-pentachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]PMID:20435555 PMID:20961953
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