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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apomorphine
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Accession:CHEBI:48538 term browser browse the term
Definition:An isoquinoline alkaloid that has formula C17H17NO2.
Synonyms:exact_synonym: 6abeta-aporphine-10,11-diol
 related_synonym: (-)-10,11-dihydroxyaporphine;   (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;   (R)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol;   Apomorphin;   Formula=C17H17NO2;   InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1;   InChIKey=VMWNQDUVQKEIOC-CYBMUJFWSA-N;   R-(-)-apomorphine;   SMILES=[H][C@]12Cc3ccc(O)c(O)c3-c3cccc(CCN1C)c23
 alt_id: CHEBI:94845
 xref: Beilstein:29319;   Beilstein:3653944;   CAS:58-00-4;   DrugBank:DB00714;   Drug_Central:228;   LINCS:LSM-25611
 xref_mesh: MESH:D001058
 xref: VSDB:2964;   Wikipedia:Apomorphine


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apomorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin increases expression
multiple interactions		 EXP Apomorphine results in increased expression of AVP protein
Metoclopramide inhibits the reaction [Apomorphine results in increased expression of AVP protein]		 CTD PMID:16575035 NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724 		JBrowse link
G BMP6 bone morphogenetic protein 6 multiple interactions EXP Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form] CTD PMID:25633564 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728 		JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A decreases expression EXP Apomorphine results in decreased expression of BMPR1A mRNA CTD PMID:25633564 NCBI chr10:86,755,763...86,932,844
Ensembl chr10:86,755,786...86,932,825 		JBrowse link
G CCK cholecystokinin multiple interactions
decreases activity		 ISO Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine] CTD PMID:3561887 NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185 		JBrowse link
G CCKBR cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Apomorphine CTD PMID:11702094 NCBI chr11:6,259,838...6,272,127
Ensembl chr11:6,259,806...6,272,127 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP Apomorphine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G DRD1 dopamine receptor D1 multiple interactions EXP
ISO		 Apomorphine binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [Apomorphine results in increased activity of DRD1 protein]
[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]		 CTD PMID:8103921 PMID:15985612 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182 		JBrowse link
G DRD2 dopamine receptor D2 multiple interactions
affects response to substance
increases response to substance		 ISO [[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]
Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]
DRD2 protein affects the susceptibility to Apomorphine
DRD2 protein results in increased susceptibility to Apomorphine		 CTD PMID:2571179 PMID:7520908 PMID:8103596 PMID:8103921 PMID:14639100 More... NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G DRD3 dopamine receptor D3 increases response to substance ISO DRD3 protein results in increased susceptibility to Apomorphine CTD PMID:19497322 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Apomorphine results in increased expression of FOS protein CTD PMID:10904129 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme decreases expression EXP Apomorphine results in decreased expression of FURIN mRNA CTD PMID:25633564 NCBI chr15:90,868,588...90,883,457
Ensembl chr15:90,868,588...90,883,564 		JBrowse link
G GDNF glial cell derived neurotrophic factor multiple interactions ISO GDNF protein affects the susceptibility to [Apomorphine co-treated with Oxidopamine] CTD PMID:11771942 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GH1 growth hormone 1 increases secretion
increases expression		 EXP Apomorphine results in increased secretion of GH1 protein
Apomorphine results in increased expression of GH1 protein		 CTD PMID:993808 PMID:8889285 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839 		JBrowse link
G HAMP hepcidin antimicrobial peptide multiple interactions
decreases secretion
decreases expression		 EXP Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]; Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Apomorphine results in decreased secretion of HAMP protein modified form
Apomorphine results in decreased expression of HAMP mRNA		 CTD PMID:25633564 NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A multiple interactions ISO [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine] CTD PMID:8539317 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507 		JBrowse link
G HTR6 5-hydroxytryptamine receptor 6 increases response to substance
multiple interactions		 ISO HTR6 protein results in increased susceptibility to Apomorphine
Ro4368554 inhibits the reaction [HTR6 protein results in increased susceptibility to Apomorphine]		 CTD PMID:17920665 NCBI chr 1:19,664,875...19,680,966
Ensembl chr 1:19,664,875...19,680,966 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Apomorphine inhibits the reaction [Oxidopamine results in increased phosphorylation of JUN protein] CTD PMID:14599342 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G ODC1 ornithine decarboxylase 1 increases activity ISO Apomorphine results in increased activity of ODC1 protein CTD PMID:10354516 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327 		JBrowse link
G PENK proenkephalin multiple interactions ISO Apomorphine inhibits the reaction [Reserpine results in increased expression of PENK mRNA] CTD PMID:17719177 NCBI chr 8:56,440,957...56,446,641
Ensembl chr 8:56,436,674...56,446,671 		JBrowse link
G PRL prolactin decreases expression EXP Apomorphine results in decreased expression of PRL protein CTD PMID:8889285 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PVALB parvalbumin affects expression ISO Apomorphine affects the expression of PVALB protein CTD PMID:15238432 NCBI chr22:36,800,703...36,819,499
Ensembl chr22:36,800,684...36,819,479 		JBrowse link
G RGS9 regulator of G protein signaling 9 affects response to substance ISO RGS9 affects the susceptibility to Apomorphine CTD PMID:15728856 NCBI chr17:65,137,370...65,227,703
Ensembl chr17:65,100,812...65,227,703 		JBrowse link
G SHH sonic hedgehog signaling molecule multiple interactions ISO SHH protein modified form affects the susceptibility to [Apomorphine co-treated with Oxidopamine] CTD PMID:11771942 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Apomorphine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SYT7 synaptotagmin 7 multiple interactions ISO [Reserpine co-treated with Apomorphine] results in increased expression of SYT7 mRNA CTD PMID:17719177 NCBI chr11:61,513,714...61,588,387
Ensembl chr11:61,513,714...61,581,148 		JBrowse link
G TAC1 tachykinin precursor 1 multiple interactions ISO Apomorphine promotes the reaction [Reserpine results in increased expression of TAC1 mRNA] CTD PMID:17719177 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      application 25177
        pharmaceutical 24551
          drug 24548
            emetic 7955
              apomorphine 27
                apomorphine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    main group molecular entity 25840
                      s-block molecular entity 25160
                        hydrogen molecular entity 24758
                          hydrides 22970
                            inorganic hydride 20486
                              pnictogen hydride 20427
                                nitrogen hydride 20203
                                  azane 19946
                                    ammonia 19945
                                      organic amino compound 19945
                                        tertiary amino compound 10435
                                          aporphine 27
                                            apomorphine 27
                                              apomorphine hydrochloride 0
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