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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:equilin
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Accession:CHEBI:42309 term browser browse the term
Definition:A 17-oxo steroid that has formula C18H20O2.
Synonyms:exact_synonym: 3-hydroxyestra-1,3,5(10),7-tetraen-17-one
 related_synonym: 1,3,5,7-Estratetraen-3-ol-17-one;   7-Dehydroestrone;   Dihydroequilenin;   Formula=C18H20O2;   InChI=1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16,19H,2,6-9H2,1H3/t14-,16+,18+/m1/s1;   InChIKey=WKRLQDKEXYKHJB-HFTRVMKXSA-N;   SMILES=[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])C1=CCc1cc(O)ccc21
 alt_id: CHEBI:34740;   CHEBI:42304
 xref: Beilstein:2624302;   CAS:474-86-2;   DrugBank:DB02187;   KEGG:C14392;   KEGG:D04041;   LINCS:LSM-2063;   LIPID_MAPS_instance:LMST02010026
 xref_mesh: MESH:D004857
 xref: PDBeChem:EQI



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equilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ar androgen receptor affects localization
multiple interactions
ISO Equilin affects the localization of AR protein
Equilin binds to and results in increased activity of AR protein; Equilin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD PMID:28478275 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Esr1 estrogen receptor 1 increases activity
affects binding
multiple interactions
EXP
ISO
Equilin results in increased activity of ESR1 protein
Equilin binds to ESR1 protein
Equilin binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [Equilin results in increased activity of ESR1 protein]
CTD PMID:11750080 PMID:12504345 PMID:21138273 PMID:22562034 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Equilin binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Equilin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Equilin binds to and results in decreased activity of NR1I2 protein
Equilin binds to and results in increased activity of NR1I2 protein
CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Equilin binds to and results in decreased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO Equilin binds to RXRA protein CTD PMID:31566444 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions
ISO Equilin results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Equilin results in increased expression of TFF1 mRNA]
CTD PMID:22562034 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Equilin binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Utrn utrophin increases expression ISO Equilin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      molecular entity 19842
        polyatomic entity 19799
          heteroatomic molecular entity 19755
            hydroxides 19331
              organic hydroxy compound 18961
                hydroxy steroid 14438
                  3-hydroxy steroid 12777
                    equilin 13
                      equilin sodium sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbonyl compound 18890
                                    ketone 17180
                                      oxo steroid 10543
                                        17-oxo steroid 266
                                          equilin 13
                                            equilin sodium sulfate 0
paths to the root