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ethion - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethion
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Accession:CHEBI:38663 term browser browse the term
Definition:An organic thiophosphate that is S,S'-methanediyl bis[dihydrogen (phosphorodithioate)] in which all the hydroxy groups have been converted to their corresponding ethyl esters respectively. Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase ( EC 3.1.1.7).
Synonyms:exact_synonym: O,O,O',O'-tetraethyl S,S'-methanediyl bis(phosphorodithioate)
 related_synonym: Bis(S-(diethoxyphosphinothioyl)mercapto)methane;   Formula=C9H22O4P2S4;   InChI=1S/C9H22O4P2S4/c1-5-10-14(16,11-6-2)18-9-19-15(17,12-7-3)13-8-4/h5-9H2,1-4H3;   InChIKey=RIZMRRKBZQXFOY-UHFFFAOYSA-N;   O,O,O',O'-Tetraethyl S,S'-methylenebis(phosphorodithioate);   O,O,O',O'-tetraethyl S,S'-methanediyl bis(dithiophosphate);   S,S'-Methylene bis(O,O-diethyl phosphorodithioate);   SMILES=CCOP(=S)(OCC)SCSP(=S)(OCC)OCC
 xref: CAS:563-12-2;   KEGG:C18725
 xref_mesh: MESH:C100038
 xref: PMID:21366965;   PMID:21560835;   PMID:23127602;   PMID:24398360;   PMID:24401442;   PPDB:276;   Reaxys:1804530;   Wikipedia:Ethion

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ethion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [ethion results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO ethion results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO ethion results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO ethion results in increased expression of IL1B mRNA
[ethion co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; Lipopolysaccharides promotes the reaction [ethion results in increased expression of IL1B mRNA]		 CTD PMID:30225615 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethion binds to and results in increased activity of NR1I2 protein
[Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased activity of NR1I2 protein; ethion binds to and results in increased activity of NR1I2 protein		 CTD PMID:21115097 PMID:25028461 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO ethion results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR4 mRNA; [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR4 protein CTD PMID:30225615 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr9 toll-like receptor 9 increases expression
multiple interactions		 ISO ethion results in increased expression of TLR9 mRNA
[ethion co-treated with Lipopolysaccharides] results in increased expression of TLR9 mRNA; [ethion co-treated with Lipopolysaccharides] results in increased expression of TLR9 protein		 CTD PMID:30225615 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [ethion co-treated with Lipopolysaccharides] results in increased expression of TNF protein CTD PMID:30225615 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO ethion metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        agrochemical 16869
          ethion 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      chalcogen 19580
                        oxygen atom 19551
                          oxygen molecular entity 19551
                            hydroxides 19361
                              oxoacid 18797
                                pnictogen oxoacid 15018
                                  phosphorus oxoacid 14577
                                    phosphoric acids 13927
                                      phosphoric acid 13927
                                        phosphoric acid derivative 13839
                                          phosphate 13838
                                            organic phosphate 13838
                                              organic thiophosphate 8624
                                                ethion 11
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