CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tributyrin
Accession: CHEBI:35020
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Definition: A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by butyric acid.
Synonyms: exact_synonym: propane-1,2,3-triyl tributanoate
related_synonym: 1,2,3-Propanetriol, tributyrate; 1,2,3-Propanetriyl tributanoate; 1,2,3-Tributyrylglycerol; 1,2,3-tributanoylglycerol; 2,3-Bis(butyryloxy)propyl butyrate; Butanoic acid, 1,2,3-propanetriyl ester; Butyrin; Butyryl triglyceride; Formula=C15H26O6; Glycerin tributyrate; Glycerol tributanoate; Glycerol tributyrate; Glyceroltributyrin; Glyceryl tributyrate; InChI=1S/C15H26O6/c1-4-7-13(16)19-10-12(21-15(18)9-6-3)11-20-14(17)8-5-2/h12H,4-11H2,1-3H3; InChIKey=UYXTWWCETRIEDR-UHFFFAOYSA-N; SMILES=CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC; Tri-n-butyrin; Tributin; Tributyryl glyceride; propane-1,2,3-triyl tributyrate
xref: CAS:60-01-5; HMDB:HMDB0031094; KEGG:C13870
xref_mesh: MESH:C005830
xref: MetaCyc:CPD-13014; PMID:23568954; PMID:23630018; PMID:23887917; PMID:24121865; PMID:24302446; PMID:24506942; PMID:24576724; PMID:24890666; Reaxys:1714746; Wikipedia:Butyrin
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
tributyrin results in decreased expression of BCL2 mRNA
CTD
PMID:11876963
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Cd86
CD86 molecule
increases expression
ISO
tributyrin results in increased expression of CD86 protein
CTD
PMID:30503584
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Ifng
interferon gamma
multiple interactions
ISO
[Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein
CTD
PMID:29198882 PMID:36870414
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il17a
interleukin 17A
multiple interactions
ISO
[Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL17A protein
CTD
PMID:36870414
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Il1b
interleukin 1 beta
increases expression
ISO
tributyrin results in increased expression of IL1B protein
CTD
PMID:30503584
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
multiple interactions
ISO
IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]; IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein]
CTD
PMID:16252257
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il4
interleukin 4
multiple interactions
ISO
[Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein
CTD
PMID:29198882 PMID:36870414
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Mapk1
mitogen activated protein kinase 1
affects phosphorylation multiple interactions
ISO
tributyrin affects the phosphorylation of MAPK1 protein IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]
CTD
PMID:16252257
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions affects phosphorylation
ISO
IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein]
CTD
PMID:16252257
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Tlr2
toll-like receptor 2
multiple interactions
EXP
tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]
CTD
PMID:21051124
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tnf
tumor necrosis factor
multiple interactions
EXP
tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:21051124
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trpa1
transient receptor potential cation channel, subfamily A, member 1
increases activity
ISO
tributyrin results in increased activity of TRPA1 protein
CTD
PMID:29198882
NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
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