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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alloxanthine
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Accession:CHEBI:28315 term browser browse the term
Definition:A pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6.
Synonyms:exact_synonym: 1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
 related_synonym: Formula=C5H4N4O2;   InChI=1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11);   InChIKey=HXNFUBHNUDHIGC-UHFFFAOYSA-N;   Oxipurinol;   Oxoallopurinol;   Oxypurinol;   SMILES=O=c1[nH]c2[nH]ncc2c(=O)[nH]1
 alt_id: CHEBI:22360;   CHEBI:2603
 xref: BPDB:2154;   Beilstein:139956;   CAS:2465-59-0;   HMDB:HMDB0000786;   KEGG:C07599;   KEGG:D02365
 xref_mesh: MESH:D010117
 xref: PMID:18484017;   PMID:23751350;   PMID:24184830;   PMID:24591375;   Reaxys:139956;   Wikipedia:Oxypurinol


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alloxanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPL alkaline phosphatase, biomineralization associated increases expression ISO Oxypurinol results in increased expression of ALPL mRNA CTD PMID:26968635 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression ISO Oxypurinol results in increased expression of BGLAP mRNA CTD PMID:26968635 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317 		JBrowse link
G CCL17 C-C motif chemokine ligand 17 multiple interactions EXP Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA] CTD PMID:28949055 NCBI chr16:57,396,093...57,416,063
Ensembl chr16:57,404,767...57,416,063 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression EXP Oxypurinol results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL22 C-C motif chemokine ligand 22 multiple interactions EXP Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA] CTD PMID:28949055 NCBI chr16:57,357,909...57,366,189
Ensembl chr16:57,358,783...57,366,189 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 increases expression EXP Oxypurinol results in increased expression of CXCL10 mRNA CTD PMID:25091725 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Oxypurinol results in increased expression of CXCL8 mRNA CTD PMID:25091725 PMID:26641773 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G DEK DEK proto-oncogene increases secretion EXP DEK protein results in increased secretion of Oxypurinol CTD PMID:28558019 NCBI chr 6:18,223,860...18,264,530
Ensembl chr 6:18,223,860...18,264,548 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression ISO Oxypurinol results in decreased expression of ENPP1 mRNA CTD PMID:26968635 NCBI chr 6:131,808,020...131,895,155
Ensembl chr 6:131,808,016...131,895,155 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP Oxypurinol results in increased expression of HMOX1 mRNA CTD PMID:25091725 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IFNG interferon gamma multiple interactions EXP Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein] CTD PMID:28949055 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP Oxypurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein] CTD PMID:28949055 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLC22A11 solute carrier family 22 member 11 multiple interactions EXP Oxypurinol inhibits the reaction [SLC22A11 protein results in increased uptake of estrone sulfate] CTD PMID:16135657 NCBI chr11:64,555,941...64,572,875
Ensembl chr11:64,555,690...64,572,875 		JBrowse link
G SLC22A12 solute carrier family 22 member 12 multiple interactions
increases uptake		 EXP Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]; Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol] CTD PMID:16135657 NCBI chr11:64,591,220...64,602,344
Ensembl chr11:64,590,641...64,602,353 		JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions		 EXP Oxypurinol results in increased expression of TNF mRNA
Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]		 CTD PMID:26641773 PMID:28949055 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G XDH xanthine dehydrogenase decreases activity ISO Oxypurinol results in decreased activity of XDH protein CTD PMID:26968635 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        biochemical role 25168
          metabolite 25098
            xenobiotic metabolite 16958
              human xenobiotic metabolite 16137
                drug metabolite 5115
                  alloxanthine 17
                    7-isobutyl-5-methyl-2-(1-naphthylmethyl)-3-(4-pyridyl)alloxanthine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic heterocyclic compound 22320
                                  organic heteropolycyclic compound 21317
                                    organic heterobicyclic compound 18560
                                      pyrazolopyrimidine 6150
                                        alloxanthine 17
                                          7-isobutyl-5-methyl-2-(1-naphthylmethyl)-3-(4-pyridyl)alloxanthine 0
paths to the root