CCL17 (C-C motif chemokine ligand 17) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CCL17 (C-C motif chemokine ligand 17) Homo sapiens
Analyze
Symbol: CCL17
Name: C-C motif chemokine ligand 17
RGD ID: 1349365
HGNC Page HGNC:10615
Description: Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; lung disease (multiple); pulmonary eosinophilia; and respiratory syncytial virus infectious disease.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A-152E5.3; ABCD-2; C-C motif chemokine 17; CC chemokine TARC; chemokine (C-C motif) ligand 17; MGC138271; MGC138273; SCYA17; small inducible cytokine subfamily A (Cys-Cys), member 17; small-inducible cytokine A17; T cell-directed CC chemokine; TARC; thymus and activation-regulated chemokine
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,396,093 - 57,416,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,404,767 - 57,416,063 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,438,679 - 57,449,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,996,180 - 56,007,475 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,996,179 - 56,007,475NCBI
Celera1641,938,673 - 41,949,969 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,306,559 - 43,317,854 (+)NCBIHuRef
CHM1_11658,846,760 - 58,858,057 (+)NCBICHM1_1
T2T-CHM13v2.01663,191,214 - 63,211,239 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alloxanthine  (EXP)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (EXP)
Bandrowski's base  (EXP)
benomyl  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
Botulinum toxin type A  (ISO)
budesonide  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
ceric oxide  (EXP,ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diflorasone  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
enzacamene  (EXP)
Fexofenadine hydrochloride  (EXP)
fragrance  (EXP)
furan  (ISO)
graphene oxide  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoprenaline  (EXP)
linuron  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nifuroxazide  (EXP)
ozone  (ISO)
pevonedistat  (EXP)
pirinixic acid  (ISO)
platycodin D  (EXP)
prostaglandin E2  (EXP)
quartz  (ISO)
resveratrol  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
tacrolimus hydrate  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
trimellitic anhydride  (ISO)
undecane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neutrophils in cystic fibrosis display a distinct gene expression pattern. Adib-Conquy M, etal., Mol Med. 2008 Jan-Feb;14(1-2):36-44.
2. ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Aki K, etal., Am J Physiol Renal Physiol. 2010 Apr;298(4):F870-82. Epub 2010 Jan 13.
3. TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Baumer W, etal., Br J Dermatol. 2004 Oct;151(4):823-30.
4. GGTI-2133, an inhibitor of geranylgeranyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma. Chiba Y, etal., Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):929-35.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis. Hartl D, etal., J Allergy Clin Immunol. 2006 Jan;117(1):204-11. Epub 2005 Nov 28.
7. CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis. Inoue T, etal., Eur Respir J. 2004 Jul;24(1):49-56.
8. Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice. Jakubzick C, etal., Am J Pathol. 2004 Oct;165(4):1211-21.
9. Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice. Kawasaki S, etal., J Immunol. 2001 Feb 1;166(3):2055-62.
10. Pathogenesis of cBFL in common with IPF? Correlation of IP-10/TARC ratio with histological patterns. Kishi M, etal., Thorax. 2008 Sep;63(9):810-6. Epub 2008 Feb 14.
11. Effects of corticosteroid on the expression of thymus and activation-regulated chemokine in a murine model of allergic asthma. Kurokawa M, etal., Int Arch Allergy Immunol. 2005;137 Suppl 1:60-8. Epub 2005 Jun 2.
12. Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis. Latzin P, etal., Eur Respir J. 2008 Jan;31(1):36-42. Epub 2007 Sep 26.
13. Elevated levels of thymus- and activation-regulated chemokine in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia. Miyazaki E, etal., Am J Respir Crit Care Med. 2002 Apr 15;165(8):1125-31.
14. Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17. Monick MM, etal., J Immunol. 2007 Aug 1;179(3):1648-58.
15. Circulating levels of both Th1 and Th2 chemokines are elevated in patients with sarcoidosis. Nureki S, etal., Respir Med. 2008 Feb;102(2):239-47. Epub 2007 Oct 18.
16. Serum thymus and activation regulated chemokine levels post-lung transplantation as a predictor for the bronchiolitis obliterans syndrome. Paantjens AW, etal., Clin Exp Immunol. 2008 Nov;154(2):202-8. Epub 2008 Sep 8.
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. Ritter M, etal., Biochem Biophys Res Commun. 2005 Aug 19;334(1):254-62.
20. Immunoreactivity profile of peripheral blood mononuclear cells from patients with ragweed-induced allergic rhinitis. Sun J, etal., Clin Exp Allergy. 2007 Jun;37(6):901-8.
21. TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas. Thielen C, etal., Leuk Res. 2008 Sep;32(9):1431-8. doi: 10.1016/j.leukres.2008.02.016. Epub 2008 Apr 18.
22. Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients. Vijayanand P, etal., J Immunol. 2010 Apr 15;184(8):4568-74. Epub 2010 Mar 17.
23. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. Ying S, etal., J Immunol. 2008 Aug 15;181(4):2790-8.
24. Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis. Yogo Y, etal., Respir Res. 2009 Aug 29;10:80.
Additional References at PubMed
PMID:8702936   PMID:9070951   PMID:9169480   PMID:9430724   PMID:9521068   PMID:9691168   PMID:10493829   PMID:10540332   PMID:10737800   PMID:11468146   PMID:12104083   PMID:12126650  
PMID:12193695   PMID:12390321   PMID:12413771   PMID:12441140   PMID:12456591   PMID:12477932   PMID:12485447   PMID:12499558   PMID:12615362   PMID:12615364   PMID:12642832   PMID:12715916  
PMID:12832759   PMID:12871855   PMID:12949249   PMID:13679391   PMID:14677179   PMID:14734737   PMID:14747532   PMID:14767451   PMID:14962085   PMID:15047814   PMID:15067078   PMID:15113590  
PMID:15335355   PMID:15474066   PMID:15489334   PMID:15500644   PMID:15813816   PMID:15944327   PMID:15955100   PMID:16583210   PMID:16859899   PMID:17023689   PMID:17546636   PMID:17548604  
PMID:17565019   PMID:17703412   PMID:17967467   PMID:17979978   PMID:18004070   PMID:18191727   PMID:18224687   PMID:18266834   PMID:18271928   PMID:18375080   PMID:18435706   PMID:18547160  
PMID:18691306   PMID:18824549   PMID:18937546   PMID:19005490   PMID:19088500   PMID:19236603   PMID:19258923   PMID:19371952   PMID:19421847   PMID:19639049   PMID:20002703   PMID:20237496  
PMID:20374230   PMID:20503287   PMID:20625996   PMID:20669282   PMID:20800454   PMID:21129807   PMID:21707761   PMID:21873635   PMID:22017510   PMID:22058214   PMID:22322668   PMID:22533972  
PMID:22775568   PMID:22981793   PMID:23224400   PMID:23225085   PMID:23340773   PMID:23454147   PMID:23705860   PMID:23731651   PMID:23782855   PMID:23822537   PMID:23942559   PMID:24102731  
PMID:24104601   PMID:24397961   PMID:24582560   PMID:24628072   PMID:24698291   PMID:24984931   PMID:25013801   PMID:25062565   PMID:25199679   PMID:25240818   PMID:25268342   PMID:25412496  
PMID:25555269   PMID:26182268   PMID:26781124   PMID:26827189   PMID:26914146   PMID:27178372   PMID:27250804   PMID:27497618   PMID:27525438   PMID:27610595   PMID:28089872   PMID:28146427  
PMID:28170001   PMID:28178948   PMID:28240436   PMID:28245475   PMID:28381538   PMID:28383711   PMID:28648978   PMID:28794385   PMID:29031579   PMID:29099057   PMID:29598931   PMID:29655215  
PMID:29746583   PMID:29848886   PMID:29871928   PMID:30953706   PMID:31131913   PMID:31322295   PMID:31456427   PMID:32265499   PMID:32399091   PMID:32439469   PMID:32677127   PMID:32761977  
PMID:33002742   PMID:33264064   PMID:33404399   PMID:33581267   PMID:33664865   PMID:33670758   PMID:33961781   PMID:34009399   PMID:34379825   PMID:34444997   PMID:34449935   PMID:34943853  
PMID:35296169   PMID:35687056   PMID:35913858   PMID:36065100   PMID:36224014   PMID:36682084   PMID:36806795   PMID:36975092   PMID:37105786   PMID:37114340   PMID:37124725   PMID:37742620  
PMID:38394497  


Genomics

Comparative Map Data
CCL17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,396,093 - 57,416,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,404,767 - 57,416,063 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,438,679 - 57,449,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,996,180 - 56,007,475 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,996,179 - 56,007,475NCBI
Celera1641,938,673 - 41,949,969 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,306,559 - 43,317,854 (+)NCBIHuRef
CHM1_11658,846,760 - 58,858,057 (+)NCBICHM1_1
T2T-CHM13v2.01663,191,214 - 63,211,239 (+)NCBIT2T-CHM13v2.0
Ccl17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,535,996 - 95,538,666 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,537,081 - 95,538,664 (+)EnsemblGRCm39 Ensembl
GRCm38894,809,380 - 94,812,038 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,810,453 - 94,812,036 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,334,353 - 97,335,936 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,699,598 - 97,701,165 (+)NCBIMGSCv36mm8
Celera899,134,583 - 99,136,166 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.85NCBI
Ccl17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,208,120 - 10,218,340 (-)NCBIGRCr8
mRatBN7.21910,202,128 - 10,203,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,202,128 - 10,203,819 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,166,373 - 10,167,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,933,217 - 10,934,668 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,220,166 - 10,221,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,619,220 - 10,620,671 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,619,220 - 10,620,671 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,614,027 - 10,615,478 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,641,376 - 10,642,827 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,646,201 - 10,647,653 (-)NCBI
Celera1910,088,700 - 10,090,151 (-)NCBICelera
Cytogenetic Map19p13NCBI
Ccl17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,053,061 - 15,054,572 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,052,616 - 15,054,732 (+)NCBIChiLan1.0ChiLan1.0
CCL17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,880,374 - 66,883,558 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,801,377 - 72,804,561 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,678,518 - 37,689,350 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,810,923 - 56,822,131 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,819,949 - 56,822,131 (+)Ensemblpanpan1.1panPan2
CCL17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,001,463 - 59,014,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,001,464 - 59,005,230 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha255,630,918 - 55,633,430 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,539,866 - 59,550,154 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,539,866 - 59,551,785 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,371,394 - 56,373,906 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,379,129 - 57,381,635 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,272,358 - 58,274,870 (-)NCBIUU_Cfam_GSD_1.0
Ccl17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,112,663 - 50,114,927 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,474,961 - 9,476,398 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,475,013 - 9,476,326 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,345,941 - 19,348,926 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1619,345,929 - 19,372,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,342,591 - 17,345,444 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCL17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,343,525 - 43,350,096 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,346,329 - 43,348,599 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604732,869,286 - 32,872,957 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccl17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,655,801 - 28,657,470 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,655,288 - 28,657,563 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CCL17
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q13-22.2(chr16:56883592-71279975)x3 copy number gain See cases [RCV000052405] Chr16:56883592..71279975 [GRCh38]
Chr16:56917504..71313878 [GRCh37]
Chr16:55475005..69871379 [NCBI36]
Chr16:16q13-22.2
pathogenic
GRCh38/hg38 16q12.2-21(chr16:55457477-63841622)x1 copy number loss See cases [RCV000133738] Chr16:55457477..63841622 [GRCh38]
Chr16:55491389..63875526 [GRCh37]
Chr16:54048890..62433027 [NCBI36]
Chr16:16q12.2-21
pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3
pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Breast ductal adenocarcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3
uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Breast ductal adenocarcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2
likely pathogenic|uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
GRCh37/hg19 16p11.2-q21(chr16:34197492-64509054)x3 copy number gain See cases [RCV000511791] Chr16:34197492..64509054 [GRCh37]
Chr16:16p11.2-q21
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3
pathogenic
GRCh37/hg19 16q13-21(chr16:56950941-60203590)x1 copy number loss not provided [RCV000683823] Chr16:56950941..60203590 [GRCh37]
Chr16:16q13-21
pathogenic|likely pathogenic
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q12.2-21(chr16:53455650-64006604)x3 copy number gain not provided [RCV000848548] Chr16:53455650..64006604 [GRCh37]
Chr16:16q12.2-21
uncertain significance
Single allele duplication not provided [RCV001542388] Chr16:46385317..61223349 [GRCh38]
Chr16:16q11.2-21
pathogenic
NM_002987.3(CCL17):c.84T>C (p.Asn28=) single nucleotide variant not provided [RCV000890630] Chr16:57415094 [GRCh38]
Chr16:57449006 [GRCh37]
Chr16:16q21
benign
GRCh37/hg19 16q13-21(chr16:57292407-59103985)x1 copy number loss not provided [RCV001259855] Chr16:57292407..59103985 [GRCh37]
Chr16:16q13-21
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46503968-90155062)x3 copy number gain not provided [RCV002221458] Chr16:46503968..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
NC_000016.9:g.(?_56226148)_(58768132_?)del deletion Bardet-Biedl syndrome [RCV003119976]|Early infantile epileptic encephalopathy with suppression bursts [RCV003109791] Chr16:56226148..58768132 [GRCh37]
Chr16:16q12.2-21
pathogenic
NC_000016.9:g.(?_57016057)_(58768132_?)del deletion not provided [RCV003122679] Chr16:57016057..58768132 [GRCh37]
Chr16:16q13-21
pathogenic
Single allele deletion not provided [RCV002266766] Chr16:53818483..57631312 [GRCh38]
Chr16:16q12.2-21
pathogenic
GRCh37/hg19 16q11.2-21(chr16:46503573-62203182)x3 copy number gain not provided [RCV002472562] Chr16:46503573..62203182 [GRCh37]
Chr16:16q11.2-21
pathogenic
NM_002987.3(CCL17):c.119G>A (p.Gly40Glu) single nucleotide variant not specified [RCV004209451] Chr16:57415129 [GRCh38]
Chr16:57449041 [GRCh37]
Chr16:16q21
uncertain significance
NM_002987.3(CCL17):c.205G>A (p.Gly69Ser) single nucleotide variant not specified [RCV004206163] Chr16:57415781 [GRCh38]
Chr16:57449693 [GRCh37]
Chr16:16q21
uncertain significance
NM_002987.3(CCL17):c.92G>A (p.Arg31Gln) single nucleotide variant not specified [RCV004083830] Chr16:57415102 [GRCh38]
Chr16:57449014 [GRCh37]
Chr16:16q21
uncertain significance
NM_002987.3(CCL17):c.121G>A (p.Ala41Thr) single nucleotide variant not specified [RCV004353465] Chr16:57415131 [GRCh38]
Chr16:57449043 [GRCh37]
Chr16:16q21
uncertain significance
GRCh37/hg19 16q12.2-22.1(chr16:55329260-67180113)x1 copy number loss not specified [RCV003987196] Chr16:55329260..67180113 [GRCh37]
Chr16:16q12.2-22.1
pathogenic
NM_002987.3(CCL17):c.46G>A (p.Ala16Thr) single nucleotide variant not specified [RCV004430541] Chr16:57413978 [GRCh38]
Chr16:57447890 [GRCh37]
Chr16:16q21
uncertain significance
NM_002987.3(CCL17):c.28G>T (p.Val10Phe) single nucleotide variant not specified [RCV004604757] Chr16:57413960 [GRCh38]
Chr16:57447872 [GRCh37]
Chr16:16q21
uncertain significance
NM_002987.3(CCL17):c.77G>T (p.Gly26Val) single nucleotide variant not specified [RCV004604756] Chr16:57415087 [GRCh38]
Chr16:57448999 [GRCh37]
Chr16:16q21
uncertain significance
NC_000016.9:g.(?_48799549)_(70756330_?)dup duplication Chromosome 16q12 duplication syndrome [RCV004595820] Chr16:48799549..70756330 [GRCh37]
Chr16:16q12.1-22.1
likely pathogenic
NM_002987.3(CCL17):c.182C>T (p.Ala61Val) single nucleotide variant not specified [RCV004604758] Chr16:57415192 [GRCh38]
Chr16:57449104 [GRCh37]
Chr16:16q21
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:302
Count of miRNA genes:285
Interacting mature miRNAs:297
Transcripts:ENST00000219244
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407262918GWAS911894_HCCL17 measurement QTL GWAS911894 (human)3e-29CCL17 measurement165740923457409235Human
406950995GWAS599971_Hfractalkine measurement QTL GWAS599971 (human)3e-27chemokine amount (VT:0008721)165740022857400229Human
407343524GWAS992500_HC-C motif chemokine 17 measurement QTL GWAS992500 (human)8e-28C-C motif chemokine 17 measurement165740827957408280Human
407038033GWAS687009_Hblood protein measurement QTL GWAS687009 (human)6e-30blood protein measurementblood protein measurement (CMO:0000028)165741009057410091Human
407233379GWAS882355_HCCL17 measurement QTL GWAS882355 (human)9e-49CCL17 measurement165740827957408280Human
406953686GWAS602662_HC-C motif chemokine 17 measurement QTL GWAS602662 (human)1e-78C-C motif chemokine 17 measurement165741009057410091Human
407212860GWAS861836_Hblood protein measurement QTL GWAS861836 (human)3e-133blood protein measurementblood protein measurement (CMO:0000028)165739942957399430Human
407288351GWAS937327_HC-C motif chemokine 17 measurement QTL GWAS937327 (human)2e-23C-C motif chemokine 17 measurement165740877757408778Human
407167214GWAS816190_HC-C motif chemokine 17 measurement QTL GWAS816190 (human)4e-15C-C motif chemokine 17 measurement165740905657409057Human
406953690GWAS602666_HC-C motif chemokine 17 measurement QTL GWAS602666 (human)3e-26C-C motif chemokine 17 measurement165741146457411465Human
407109691GWAS758667_Heosinophil count QTL GWAS758667 (human)1e-14eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)165741009057410091Human

Markers in Region
RH80761  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371657,449,768 - 57,449,961UniSTSGRCh37
Build 361656,007,269 - 56,007,462RGDNCBI36
Celera1641,949,763 - 41,949,956RGD
Cytogenetic Map16q13UniSTS
HuRef1643,317,648 - 43,317,841UniSTS
GeneMap99-GB4 RH Map16372.39UniSTS
RH66539  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371657,449,776 - 57,449,907UniSTSGRCh37
Build 361656,007,277 - 56,007,408RGDNCBI36
Celera1641,949,771 - 41,949,902RGD
Cytogenetic Map16q13UniSTS
HuRef1643,317,656 - 43,317,787UniSTS
GeneMap99-GB4 RH Map16373.25UniSTS
NCBI RH Map16450.7UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
889 1574 1937 1274 3913 1250 1909 3 537 1292 378 2047 4658 4136 9 2673 713 1320 1320 168

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011523256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB088475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB089192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC009052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC112066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC112068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE061171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D43767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000219244   ⟹   ENSP00000219244
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1657,404,767 - 57,416,063 (+)Ensembl
Ensembl Acc Id: ENST00000616880   ⟹   ENSP00000480147
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1657,413,869 - 57,416,062 (+)Ensembl
RefSeq Acc Id: NM_002987   ⟹   NP_002978
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,404,767 - 57,416,063 (+)NCBI
GRCh371657,438,679 - 57,449,974 (+)ENTREZGENE
Build 361655,996,180 - 56,007,475 (+)NCBI Archive
HuRef1643,306,559 - 43,317,854 (+)ENTREZGENE
CHM1_11658,846,760 - 58,858,057 (+)NCBI
T2T-CHM13v2.01663,199,942 - 63,211,239 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011523256   ⟹   XP_011521558
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,396,093 - 57,416,063 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017023530   ⟹   XP_016879019
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,396,093 - 57,416,063 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047434448   ⟹   XP_047290404
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,413,869 - 57,416,063 (+)NCBI
RefSeq Acc Id: XM_054313597   ⟹   XP_054169572
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01663,191,214 - 63,211,239 (+)NCBI
RefSeq Acc Id: XM_054313598   ⟹   XP_054169573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01663,191,214 - 63,211,239 (+)NCBI
RefSeq Acc Id: NP_002978   ⟸   NM_002987
- Peptide Label: precursor
- UniProtKB: A0N0Q9 (UniProtKB/Swiss-Prot),   Q2M287 (UniProtKB/Swiss-Prot),   Q92583 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011521558   ⟸   XM_011523256
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016879019   ⟸   XM_017023530
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000219244   ⟸   ENST00000219244
Ensembl Acc Id: ENSP00000480147   ⟸   ENST00000616880
RefSeq Acc Id: XP_047290404   ⟸   XM_047434448
- Peptide Label: isoform X3
- UniProtKB: Q92583 (UniProtKB/Swiss-Prot),   A0N0Q9 (UniProtKB/Swiss-Prot),   Q2M287 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054169572   ⟸   XM_054313597
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054169573   ⟸   XM_054313598
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q92583-F1-model_v2 AlphaFold Q92583 1-94 view protein structure

Promoters
RGD ID:7232321
Promoter ID:EPDNEW_H21907
Type:multiple initiation site
Name:CCL17_1
Description:C-C motif chemokine ligand 17
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,413,869 - 57,413,929EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10615 AgrOrtholog
COSMIC CCL17 COSMIC
Ensembl Genes ENSG00000102970 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000219244 ENTREZGENE
  ENST00000219244.9 UniProtKB/Swiss-Prot
  ENST00000616880 ENTREZGENE
  ENST00000616880.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
GTEx ENSG00000102970 GTEx
HGNC ID HGNC:10615 ENTREZGENE
Human Proteome Map CCL17 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:6361 UniProtKB/Swiss-Prot
NCBI Gene 6361 ENTREZGENE
OMIM 601520 OMIM
PANTHER C-C MOTIF CHEMOKINE 17 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35548 PharmGKB
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt A0N0Q9 ENTREZGENE
  CCL17_HUMAN UniProtKB/Swiss-Prot
  Q2M287 ENTREZGENE
  Q92583 ENTREZGENE
UniProt Secondary A0N0Q9 UniProtKB/Swiss-Prot
  Q2M287 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CCL17  C-C motif chemokine ligand 17  CCL17  chemokine (C-C motif) ligand 17  Symbol and/or name change 5135510 APPROVED