selinexor - Ontology Report - Rat Genome Database

[selinexor co-treated with INCB057643] results in decreased phosphorylation of ATM protein

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

Atr

ATR serine/threonine kinase

multiple interactions

[selinexor co-treated with INCB057643] results in decreased phosphorylation of ATR protein

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

Bbc3

Bcl-2 binding component 3

multiple interactions
increases expression

[INCB057643 co-treated with selinexor] results in increased expression of BBC3 protein
selinexor results in increased expression of BBC3 protein

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

Chek1

checkpoint kinase 1

multiple interactions

[selinexor co-treated with INCB057643] results in decreased phosphorylation of CHEK1 protein

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

Chek2

checkpoint kinase 2

multiple interactions

[selinexor co-treated with INCB057643] results in decreased phosphorylation of CHEK2 protein

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

H2ax

H2A.X variant histone

increases expression
multiple interactions

selinexor results in increased expression of H2AX protein
[selinexor co-treated with INCB057643] results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

Mdm2

MDM2 proto-oncogene

increases expression
multiple interactions

selinexor results in increased expression of MDM2 protein
[INCB057643 co-treated with selinexor] results in increased expression of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

Myc

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases expression

INCB057643 promotes the reaction [selinexor results in decreased expression of MYC mRNA]; INCB057643 promotes the reaction [selinexor results in decreased expression of MYC protein]; selinexor promotes the reaction [INCB057643 results in decreased expression of MYC mRNA]; selinexor promotes the reaction [INCB057643 results in decreased expression of MYC protein]
selinexor results in decreased expression of MYC mRNA; selinexor results in decreased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

Pmaip1

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

[INCB057643 co-treated with selinexor] results in increased expression of PMAIP1 protein

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

Tp53

tumor protein p53

increases expression
multiple interactions

selinexor results in increased expression of TP53 protein
[INCB057643 co-treated with selinexor] results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Tp73

tumor protein p73

increases expression

selinexor results in increased expression of TP73 protein

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

Wee1

WEE1 G2 checkpoint kinase

multiple interactions

[selinexor co-treated with INCB057643] results in decreased phosphorylation of WEE1 protein