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dopaminechrome (enol form) - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dopaminechrome (enol form)
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Accession:CHEBI:188999 term browser browse the term
Definition:A member of the class of indolones that is 3,5-dihydro-2H-indole substituted by an oxo group at position 5 and a hydroxy group at position 6.
Synonyms:related_synonym: 2,3-dihydro-6-hydroxy-5H-indol-5-one;   6-hydroxy-2,3-dihydroindol-5-one;   6-hydroxy-3,5-dihydro-2H-indol-5-one;   Formula=C8H7NO2;   InChI=1S/C8H7NO2/c10-7-3-5-1-2-9-6(5)4-8(7)11/h3-4,11H,1-2H2;   InChIKey=KAZWRYIEJRERSG-UHFFFAOYSA-N;   SMILES=OC1=CC2=NCCC2=CC1=O;   aminochrome;   aminochrome 1;   dopaminochrome
 xref: CAS:39984-17-3
 xref_mesh: MESH:C091584
 xref: PMID:34388859;   PMID:8405659
 cyclic_relationship: is_tautomer_of CHEBI:189002

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dopaminechrome (enol form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor, type 2 decreases expression EXP aminochrome 1 results in decreased expression of AGTR2 mRNA CTD PMID:18522901 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity 		EXP [aminochrome 1 co-treated with Dicumarol] results in increased activity of CASP3 protein
aminochrome 1 results in increased activity of CASP3 protein 		CTD PMID:21427056 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP [aminochrome 1 co-treated with Dicumarol] affects the localization of CYCS protein CTD PMID:21427056 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Gdnf glial cell derived neurotrophic factor decreases expression EXP aminochrome 1 results in decreased expression of GDNF mRNA CTD PMID:29588162 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP aminochrome 1 results in decreased expression of GFAP protein CTD PMID:29588162 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Il1b interleukin 1 beta increases expression EXP aminochrome 1 results in increased expression of IL1B mRNA; aminochrome 1 results in increased expression of IL1B protein CTD PMID:29588162 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ngf nerve growth factor decreases expression EXP aminochrome 1 results in decreased expression of NGF mRNA CTD PMID:29588162 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects response to substance
multiple interactions 		EXP
ISO 		NQO1 protein affects the susceptibility to aminochrome 1
NQO1 protein inhibits the reaction [aminochrome 1 promotes the reaction [SNCA protein binds to SNCA protein]] 		CTD PMID:20849151 PMID:25634539 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Snca synuclein alpha multiple interactions ISO aminochrome 1 promotes the reaction [SNCA protein binds to SNCA protein]; NQO1 protein inhibits the reaction [aminochrome 1 promotes the reaction [SNCA protein binds to SNCA protein]] CTD PMID:25634539 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Th tyrosine hydroxylase decreases expression EXP aminochrome 1 results in decreased expression of TH protein CTD PMID:29588162 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP aminochrome 1 results in increased expression of TNF mRNA; aminochrome 1 results in increased expression of TNF protein CTD PMID:29588162 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    chemical entity 19885
      molecular entity 19884
        polyatomic entity 19835
          heteroatomic molecular entity 19790
            hydroxides 19361
              organic hydroxy compound 18971
                enol 750
                  dopaminechrome (enol form) 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  organic heteropolycyclic compound 18302
                                    organic heterobicyclic compound 17242
                                      benzopyrrole 9750
                                        indoles 9440
                                          indolones 5940
                                            dopaminechrome (enol form) 11
paths to the root