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ornithine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ornithine
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Accession:CHEBI:18257 term browser browse the term
Definition:An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5.
Synonyms:related_synonym: 2,5-Diaminopentanoic acid;   2,5-Diaminovaleric acid;   DL-Ornithine;   Formula=C5H12N2O2;   InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9);   InChIKey=AHLPHDHHMVZTML-UHFFFAOYSA-N;   Orn;   SMILES=NCCCC(N)C(O)=O
 alt_id: CHEBI:7784
 xref: CAS:616-07-9;   Gmelin:847696;   KEGG:C01602;   KNApSAcK:C00001384
 xref_mesh: MESH:D009952
 xref: PMID:15449570;   PMID:17190852;   PMID:22264337;   Reaxys:1722296
 cyclic_relationship: is_conjugate_acid_of CHEBI:32964;   is_conjugate_base_of CHEBI:46912


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ornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Ornithine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Ornithine] CTD PMID:39172838 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine] CTD PMID:22689575 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Ornithine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Ornithine] CTD PMID:39172838 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
eflornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mdm2 MDM2 proto-oncogene decreases expression EXP Eflornithine results in decreased expression of MDM2 mRNA CTD PMID:11502571 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP [[Eflornithine results in decreased abundance of Polyamines] which results in decreased expression of and results in decreased activity of PLCG1 protein] which results in decreased abundance of Inositol 1,4,5-Trisphosphate; [Eflornithine results in decreased abundance of Polyamines] which results in decreased expression of and results in decreased activity of PLCG1 protein; [Eflornithine results in decreased abundance of Polyamines] which results in decreased expression of PLCG1 mRNA CTD PMID:16973916 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases stability
increases expression
EXP Spermidine inhibits the reaction [Eflornithine results in increased expression of TP53 mRNA]
Eflornithine results in increased stability of TP53 mRNA; Eflornithine results in increased stability of TP53 protein
CTD PMID:11502571 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
rhodotorulic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
ISO Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
S-methyl-L-thiocitrulline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] CTD PMID:16380457 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases activity
EXP
ISO
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine
CTD PMID:11006970 PMID:12511180 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:17683483 NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
sinefungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 decreases activity ISO sinefungin results in decreased activity of DNMT1 protein CTD PMID:23671287 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases activity ISO sinefungin results in decreased activity of DNMT3A protein CTD PMID:23671287 NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:26,822,609...26,896,687
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          metabolite 19554
            eukaryotic metabolite 19381
              algal metabolite 16154
                ornithine 12
                  D-ornithine + 0
                  L-ornithine + 6
                  N(2)-ornithino group + 0
                  N(5)-ornithino group + 0
                  eflornithine + 3
                  ornithine derivative + 4
                  ornithine residue + 0
                  ornithyl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    main group molecular entity 19824
                      s-block molecular entity 19658
                        hydrogen molecular entity 19640
                          hydrides 19145
                            inorganic hydride 18162
                              pnictogen hydride 18152
                                nitrogen hydride 18059
                                  azane 17869
                                    ammonia 17868
                                      organic amino compound 17868
                                        amino acid 16061
                                          non-proteinogenic amino acid 4017
                                            non-proteinogenic alpha-amino acid 3811
                                              ornithine 12
                                                D-ornithine + 0
                                                L-ornithine + 6
                                                N(2)-ornithino group + 0
                                                N(5)-ornithino group + 0
                                                eflornithine + 3
                                                ornithine derivative + 4
                                                ornithine residue + 0
                                                ornithyl group + 0
paths to the root