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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-ornithine
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Accession:CHEBI:15729 term browser browse the term
Definition:An optically active form of ornithine having L-configuration.
Synonyms:related_synonym: (2S)-2,5-diaminopentanoic acid;   (S)-2,5-Diaminopentanoate;   (S)-2,5-Diaminopentanoic acid;   (S)-2,5-diaminovaleric acid;   (S)-alpha,delta-diaminovaleric acid;   (S)-ornithine;   Formula=C5H12N2O2;   InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1;   InChIKey=AHLPHDHHMVZTML-BYPYZUCNSA-N;   SMILES=NCCC[C@H](N)C(O)=O
 alt_id: CHEBI:13148;   CHEBI:21367;   CHEBI:6280
 xref: Beilstein:1722298;   CAS:70-26-8;   DrugBank:DB00129;   Drug_Central:3401;   Gmelin:327282;   HMDB:HMDB0000214;   KEGG:C00077;   KEGG:D08302;   KNApSAcK:C00001384;   MetaCyc:ORNITHINE;   PDBeChem:ORN;   PMID:15576628;   PMID:17190852;   PMID:18676473;   PMID:19083482;   PMID:19173225;   PMID:22033378;   PMID:22133808;   PMID:22387109;   PMID:22735334;   Reaxys:1722298;   Wikipedia:Ornithine
 cyclic_relationship: is_conjugate_acid_of CHEBI:46914;   is_conjugate_base_of CHEBI:46911;   is_enantiomer_of CHEBI:16176



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rhodotorulic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
ISO Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
S-methyl-L-thiocitrulline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] CTD PMID:16380457 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases activity
EXP
ISO
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine
CTD PMID:11006970 PMID:12511180 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:17683483 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
sinefungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 decreases activity ISO sinefungin results in decreased activity of DNMT1 protein CTD PMID:23671287 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases activity ISO sinefungin results in decreased activity of DNMT3A protein CTD PMID:23671287 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      application 19679
        pharmaceutical 19495
          drug 19520
            protective agent 18202
              hepatoprotective agent 5543
                L-ornithine 6
                  L-Orn-D-Asp 0
                  L-Orn-D-Glu 0
                  L-ornithine derivative + 4
                  L-ornithine residue + 0
                  L-ornithine-d6 0
                  L-ornithyl group 0
                  N(2)-L-ornithino group 0
                  N(5)-L-ornithino group 0
                  sinefungin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    main group molecular entity 19806
                      s-block molecular entity 19616
                        hydrogen molecular entity 19596
                          hydrides 19108
                            inorganic hydride 18111
                              pnictogen hydride 18100
                                nitrogen hydride 18008
                                  azane 17815
                                    ammonia 17837
                                      organic amino compound 17814
                                        amino acid 15950
                                          alpha-amino acid 13859
                                            non-proteinogenic alpha-amino acid 3793
                                              ornithine 7
                                                L-ornithine 6
                                                  L-Orn-D-Asp 0
                                                  L-Orn-D-Glu 0
                                                  L-ornithine derivative + 4
                                                  L-ornithine residue + 0
                                                  L-ornithine-d6 0
                                                  L-ornithyl group 0
                                                  N(2)-L-ornithino group 0
                                                  N(5)-L-ornithino group 0
                                                  sinefungin 2
paths to the root