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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-ornithine
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Accession:CHEBI:15729 term browser browse the term
Definition:An optically active form of ornithine having L-configuration.
Synonyms:related_synonym: (2S)-2,5-diaminopentanoic acid;   (S)-2,5-Diaminopentanoate;   (S)-2,5-Diaminopentanoic acid;   (S)-2,5-diaminovaleric acid;   (S)-alpha,delta-diaminovaleric acid;   (S)-ornithine;   Formula=C5H12N2O2;   InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1;   InChIKey=AHLPHDHHMVZTML-BYPYZUCNSA-N;   SMILES=NCCC[C@H](N)C(O)=O
 alt_id: CHEBI:13148;   CHEBI:21367;   CHEBI:6280
 xref: Beilstein:1722298;   CAS:70-26-8;   DrugBank:DB00129;   Drug_Central:3401;   Gmelin:327282;   HMDB:HMDB0000214;   KEGG:C00077;   KEGG:D08302;   KNApSAcK:C00001384;   MetaCyc:ORNITHINE;   PDBeChem:ORN;   PMID:15576628;   PMID:17190852;   PMID:18676473;   PMID:19083482;   PMID:19173225;   PMID:22033378;   PMID:22133808;   PMID:22387109;   PMID:22735334;   Reaxys:1722298;   Wikipedia:Ornithine
 cyclic_relationship: is_conjugate_acid_of CHEBI:46914;   is_conjugate_base_of CHEBI:46911;   is_enantiomer_of CHEBI:16176


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rhodotorulic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
ISO Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
S-methyl-L-thiocitrulline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] CTD PMID:16380457 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases activity
EXP
ISO
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine
CTD PMID:11006970, PMID:12511180 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:17683483 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
sinefungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 decreases activity ISO sinefungin results in decreased activity of DNMT1 protein CTD PMID:23671287 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases activity ISO sinefungin results in decreased activity of DNMT3A protein CTD PMID:23671287 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            protective agent 16363
              hepatoprotective agent 3847
                L-ornithine 6
                  L-Orn-D-Asp 0
                  L-Orn-D-Glu 0
                  L-ornithine derivative + 4
                  L-ornithine residue + 0
                  L-ornithyl group 0
                  N(2)-L-ornithino group 0
                  N(5)-L-ornithino group 0
                  sinefungin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        amino acid 14085
                                          alpha-amino acid 11550
                                            non-proteinogenic alpha-amino acid 1545
                                              ornithine 7
                                                L-ornithine 6
                                                  L-Orn-D-Asp 0
                                                  L-Orn-D-Glu 0
                                                  L-ornithine derivative + 4
                                                  L-ornithine residue + 0
                                                  L-ornithyl group 0
                                                  N(2)-L-ornithino group 0
                                                  N(5)-L-ornithino group 0
                                                  sinefungin 2
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