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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Flavokawain A
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Accession:CHEBI:157725 term browser browse the term
Synonyms:exact_synonym: (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
 related_synonym: Formula=C18H18O5;   InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+;   InChIKey=CGIBCVBDFUTMPT-RMKNXTFCSA-N;   SMILES=O(C=1C(=C(O)C=C(OC)C1)C(=O)/C=C/C2=CC=C(OC)C=C2)C
 xref: Chemspider:4511445;   HMDB:0033586
 xref_mesh: MESH:C500809


show annotations for term's descendants           Sort by:
Flavokawain A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO flavokawain A inhibits the reaction [Lipopolysaccharides affects the localization of [JUN protein binds to FOS protein]] CTD PMID:23727179 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:23727179 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:23727179 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO flavokawain A inhibits the reaction [Lipopolysaccharides affects the localization of [JUN protein binds to FOS protein]]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein] CTD PMID:23727179 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO flavokawain A inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:23727179 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO flavokawain A inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:23727179 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO flavokawain A inhibits the reaction [Lipopolysaccharides promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:23727179 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO flavokawain A inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:23727179 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:23727179 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      atom 19839
        nonmetal atom 19777
          oxygen atom 19520
            oxygen molecular entity 19520
              flavonoids 11608
                chalcones 934
                  Flavokawain A 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbonyl compound 18898
                                    ketone 17187
                                      alpha,beta-unsaturated ketone 9969
                                        enone 9969
                                          chalcones 934
                                            Flavokawain A 9
paths to the root