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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:quinapril(1+)
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Accession:CHEBI:141523 term browser browse the term
Definition:An ammonium ion resulting from the protonation of the secondary amino group of quinapril.
Synonyms:exact_synonym: (2S)-N-{(2S)-1-[(3S)-3-carboxy-3,4-dihydroisoquinolin-2(1H)-yl]-1-oxopropan-2-yl}-1-ethoxy-1-oxo-4-phenylbutan-2-aminium
 related_synonym: Formula=C25H31N2O5;   InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/p+1/t17-,21-,22-/m0/s1;   InChIKey=JSDRRTOADPPCHY-HSQYWUDLSA-O;   SMILES=C1C2=C(C[C@H](N1C([C@@H]([NH2+][C@H](C(OCC)=O)CCC=3C=CC=CC3)C)=O)C(O)=O)C=CC=C2
 cyclic_relationship: is_conjugate_acid_of CHEBI:8173


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quinapril hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme decreases activity EXP
ISO		 Quinapril results in decreased activity of ACE protein CTD PMID:8227822 PMID:15728788 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ADM adrenomedullin decreases expression ISO Quinapril results in decreased expression of ADM protein CTD PMID:10334802 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397 		JBrowse link
G AGT angiotensinogen multiple interactions
decreases activity		 ISO Quinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]
Quinapril results in decreased activity of AGT protein		 CTD PMID:11709406 PMID:15728788 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases expression ISO Quinapril results in decreased expression of CXCL10 CTD PMID:15831368 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 decreases activity EXP Quinapril results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773 		JBrowse link
G EDN1 endothelin 1 decreases expression EXP Quinapril results in decreased expression of EDN1; Quinapril results in decreased expression of EDN1 protein CTD PMID:12149661 PMID:12425201 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G F2 coagulation factor II, thrombin decreases activity EXP Quinapril results in decreased activity of F2 protein CTD PMID:16907931 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506 		JBrowse link
G F5 coagulation factor V decreases activity EXP Quinapril results in decreased activity of F5 protein CTD PMID:16907931 NCBI chr 1:169,511,951...169,586,481
Ensembl chr 1:169,511,951...169,586,588 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Quinapril results in increased expression of FOS mRNA CTD PMID:8539265 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO [Tacrolimus co-treated with Quinapril] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Quinapril] results in increased expression of IL6 protein CTD PMID:16549154 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression ISO Quinapril results in increased expression of MYC mRNA CTD PMID:8539265 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NOS3 nitric oxide synthase 3 affects expression ISO Quinapril affects the expression of NOS3 mRNA CTD PMID:12176110 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NPPA natriuretic peptide A increases expression
increases secretion		 ISO Quinapril results in increased expression of NPPA mRNA; Quinapril results in increased expression of NPPA protein
Quinapril results in increased secretion of NPPA protein		 CTD PMID:14639023 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G PTHLH parathyroid hormone like hormone multiple interactions ISO Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733 		JBrowse link
G REN renin increases expression
multiple interactions		 ISO Quinapril results in increased expression of REN protein
Quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]		 CTD PMID:10334802 PMID:11709406 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324 		JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP Quinapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr13:98,683,801...98,752,672
Ensembl chr13:98,683,801...98,752,672 		JBrowse link
G SLC15A2 solute carrier family 15 member 2 multiple interactions EXP
ISO		 Quinapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr 3:121,894,401...121,944,188
Ensembl chr 3:121,894,401...121,944,188 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [Tacrolimus co-treated with Quinapril] results in increased expression of TGFB1 protein CTD PMID:16549154 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26503
    role 26325
      biological role 26304
        biochemical role 25517
          cofactor 19011
            ammonium 8218
              ammonium ion derivative 8213
                quinapril(1+) 18
                  quinapril hydrochloride 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 26503
    subatomic particle 26479
      composite particle 26479
        hadron 26479
          baryon 26479
            nucleon 26479
              atomic nucleus 26479
                atom 26479
                  main group element atom 26216
                    main group molecular entity 26216
                      s-block molecular entity 25453
                        hydrogen molecular entity 24860
                          hydrides 23080
                            inorganic hydride 20556
                              pnictogen hydride 20498
                                nitrogen hydride 20284
                                  ammonium 8218
                                    ammonium ion derivative 8213
                                      quinapril(1+) 18
                                        quinapril hydrochloride 18
paths to the root