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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quinapril hydrochloride
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Accession:CHEBI:8714 term browser browse the term
Definition:A hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure.
Synonyms:exact_synonym: (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride;   (3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride;   (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
 related_synonym: Accupril;   Accuprin;   Accupro;   Acequin;   Acuitel;   CI-906;   Formula=C25H30N2O5.HCl;   Formula=C25H31ClN2O5;   Hemokvin;   InChI=1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1;   InChIKey=IBBLRJGOOANPTQ-JKVLGAQCSA-N;   Korec;   Quinazil;   SMILES=C1C2=C(C[C@H](N1C([C@@H](N[C@H](C(OCC)=O)CCC=3C=CC=CC3)C)=O)C(O)=O)C=CC=C2.Cl
 xref: Beilstein:5699760;   CAS:82586-55-8;   Drug_Central:2340;   KEGG:C07340;   KEGG:D00459
 xref_mesh: MESH:C041125
 xref: PMID:12749406;   PMID:16193811;   PMID:24081473;   PMID:29310224;   PMID:8959644;   Patent:US7482361;   Patent:WO2004087671


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quinapril hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP
ISO
Quinapril results in decreased activity of ACE protein CTD PMID:8227822 PMID:15728788 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Adm adrenomedullin decreases expression EXP Quinapril results in decreased expression of ADM protein CTD PMID:10334802 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Agt angiotensinogen decreases activity
multiple interactions
EXP Quinapril results in decreased activity of AGT protein
Quinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]
CTD PMID:11709406 PMID:15728788 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Quinapril results in decreased expression of CXCL10 CTD PMID:15831368 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Quinapril results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Quinapril results in decreased expression of EDN1; Quinapril results in decreased expression of EDN1 protein CTD PMID:12149661 PMID:12425201 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G F2 coagulation factor II decreases activity ISO Quinapril results in decreased activity of F2 protein CTD PMID:16907931 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F5 coagulation factor V decreases activity ISO Quinapril results in decreased activity of F5 protein CTD PMID:16907931 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Quinapril results in increased expression of FOS mRNA CTD PMID:8539265 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Tacrolimus co-treated with Quinapril] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Quinapril] results in increased expression of IL6 protein CTD PMID:16549154 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Quinapril results in increased expression of MYC mRNA CTD PMID:8539265 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nos3 nitric oxide synthase 3 affects expression EXP Quinapril affects the expression of NOS3 mRNA CTD PMID:12176110 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A increases expression
increases secretion
EXP Quinapril results in increased expression of NPPA mRNA; Quinapril results in increased expression of NPPA protein
Quinapril results in increased secretion of NPPA protein
CTD PMID:14639023 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ren renin multiple interactions
increases expression
EXP Quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]
Quinapril results in increased expression of REN protein
CTD PMID:10334802 PMID:11709406 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Quinapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP
ISO
Quinapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Tacrolimus co-treated with Quinapril] results in increased expression of TGFB1 protein CTD PMID:16549154 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link

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  CHEBI ontology 19817
    role 19767
      application 19445
        pharmaceutical 19319
          drug 19319
            cardiovascular drug 7665
              antihypertensive agent 1835
                quinapril hydrochloride 18
Path 2
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  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    main group molecular entity 19705
                      s-block molecular entity 19458
                        hydrogen molecular entity 19451
                          hydrides 18730
                            inorganic hydride 17476
                              pnictogen hydride 17450
                                nitrogen hydride 17296
                                  ammonium 8225
                                    ammonium ion derivative 8221
                                      quinapril(1+) 18
                                        quinapril hydrochloride 18
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