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ONTOLOGY REPORT - ANNOTATIONS


Term:quinapril hydrochloride
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Accession:CHEBI:8714 term browser browse the term
Definition:A hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure.
Synonyms:exact_synonym: (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride;   (3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride;   (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
 related_synonym: Accupril;   Accuprin;   Accupro;   Acequin;   Acuitel;   CI-906;   Formula=C25H30N2O5.HCl;   Formula=C25H31ClN2O5;   Hemokvin;   InChI=1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1;   InChIKey=IBBLRJGOOANPTQ-JKVLGAQCSA-N;   Korec;   Quinazil;   SMILES=C1C2=C(C[C@H](N1C([C@@H](N[C@H](C(OCC)=O)CCC=3C=CC=CC3)C)=O)C(O)=O)C=CC=C2.Cl
 xref: Beilstein:5699760 "Beilstein";   CAS:82586-55-8 "ChemIDplus";   CAS:82586-55-8 "KEGG COMPOUND";   Drug_Central:2340 "DrugCentral";   KEGG:C07340;   KEGG:D00459
 xref_mesh: MESH:C041125
 xref: PMID:12749406 "Europe PMC";   PMID:16193811 "Europe PMC";   PMID:24081473 "Europe PMC";   PMID:29310224 "Europe PMC";   PMID:8959644 "Europe PMC";   Patent:US7482361;   Patent:WO2004087671


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quinapril hydrochloride term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:6480464
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Pthlh parathyroid hormone-like hormone JBrowse link 4 181,663,425 181,674,181 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Slc15a1 solute carrier family 15 member 1 JBrowse link 15 106,800,081 106,844,668 RGD:6480464
G Slc15a2 solute carrier family 15 member 2 JBrowse link 11 66,932,664 66,961,708 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      application 19353
        pharmaceutical 19222
          drug 19222
            cardiovascular drug 7584
              antihypertensive agent 1644
                quinapril hydrochloride 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    main group molecular entity 19637
                      s-block molecular entity 19397
                        hydrogen molecular entity 19386
                          hydrides 18356
                            inorganic hydride 17216
                              pnictogen hydride 17180
                                nitrogen hydride 17014
                                  ammonium 8225
                                    ammonium ion derivative 8220
                                      quinapril(1+) 18
                                        quinapril hydrochloride 18
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