The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A pyrrolopyrazole that is 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole which is substituted at positions 2 and 3 by 6-methylpyridin-2-yl and 6-(aminocarbonyl)quinolin-4-yl groups, respectively. A Transforming growth factor-betaRI (TGF-betaRI) kinase inhibitor, it blocks TGF-beta-mediated tumor growth in glioblastoma.
[ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein
[ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA]; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA]; LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
browse the term
