Mmp1 (matrix metallopeptidase 1) - Rat Genome Database

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Gene: Mmp1 (matrix metallopeptidase 1) Rattus norvegicus
Analyze
Symbol: Mmp1
Name: matrix metallopeptidase 1
RGD ID: 1307917
Description: Enables peptidase activity. Involved in several processes, including cellular response to cytokine stimulus; female gonad development; and positive regulation of cell migration. Located in extracellular space. Used to study several diseases, including artery disease (multiple); degenerative disc disease; liver cirrhosis; pulmonary fibrosis; and ulcerative colitis. Biomarker of several diseases, including chronic obstructive pulmonary disease; liver cirrhosis; scoliosis; tendinitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1); PARTICIPATES IN atherosclerosis pathway; endothelin signaling pathway; syndecan signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; alpha-naphthoflavone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Clgn; fibroblast collagenase; interstitial collagenase; LOC300339; matrix metallopeptidase 1 (interstitial collagenase); matrix metallopeptidase 1a; matrix metallopeptidase 1a (interstitial collagenase); matrix metalloproteinase 1; matrix metalloproteinase 1a (interstitial collagenase); matrix metalloproteinase-1; MMP-1; Mmp1a; myocardial collagenase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8812,943,453 - 12,963,966 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl812,943,453 - 12,963,964 (+)EnsemblGRCr8
mRatBN7.284,658,588 - 4,679,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,658,588 - 4,679,097 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx88,618,256 - 8,638,758 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,916,028 - 6,936,530 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,918,249 - 4,938,764 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,703,206 - 5,723,593 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,703,206 - 5,723,591 (+)Ensemblrn6Rnor6.0
Rnor_5.085,706,054 - 5,726,441 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.484,333,773 - 4,354,284 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera86,218,410 - 6,238,921 (+)NCBICelera
RGSC_v3.184,333,814 - 4,353,725 (+)NCBI
Cytogenetic Map8q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Adult Cerebral Astrocytoma  (ISO)
Airway Obstruction  (ISO)
Amaurosis Fugax  (ISO)
amyotrophic lateral sclerosis  (ISO)
Aneurysm  (ISO)
aortic valve stenosis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Barrett's esophagus  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
cervical cancer  (ISO)
cholesteatoma of middle ear  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Periodontitis  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Nephrotic Syndrome with or without Ocular Abnormalities  (ISO)
congestive heart failure  (IDA,ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
degenerative disc disease  (IDA)
dermatomyositis  (ISO)
dilated cardiomyopathy  (ISO)
Dissecting Aneurysm  (ISO)
Emphysema  (ISO)
end stage renal disease  (ISO)
epidermolysis bullosa dystrophica  (ISO)
esophagus adenocarcinoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (IDA,IEP)
Experimental Autoimmune Uveitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fetal Hypoxia  (IEP)
glomerulosclerosis  (IDA,IEP)
Head and Neck Neoplasms  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
Hyperplasia  (IDA)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
idiopathic pulmonary fibrosis  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
intermediate coronary syndrome  (ISO)
interstitial lung disease 2  (ISO)
Kidney Neoplasms  (ISO)
Knee Osteoarthritis  (IEP)
liver cirrhosis  (IDA,IEP)
localized scleroderma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
obstructive lung disease  (ISO)
ocular hypertension  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
ovarian cancer  (ISO)
periodontitis  (ISO)
polymyositis  (ISO)
preterm premature rupture of the membranes  (ISO)
primary open angle glaucoma  (ISO)
psoriatic arthritis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IDA)
pulmonary hypertension  (IDA)
recessive dystrophic epidermolysis bullosa  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
rheumatoid arthritis  (ISO)
scoliosis  (IEP)
Sepsis  (IEP)
skin melanoma  (ISO)
stomach carcinoma  (ISO)
stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sudden Hearing Loss  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
tendinitis  (IEP)
thoracic aortic aneurysm  (ISO)
thrombosis  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
ulcerative colitis  (IDA)
urinary bladder cancer  (ISO)
varicose veins  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3-hydroxypicolinic acid  (ISO)
3-Methoxynobiletin  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetaldehyde  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP,ISO)
aluminium oxide  (ISO)
amitrole  (ISO)
Ammothamnine  (ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
Arg-Gly-Asp  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asiatic acid  (ISO)
Azaspiracid  (ISO)
azithromycin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
benzylpenicillin  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (ISO)
Bis-(1-chloro-2-propyl) phosphate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bufalin  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carazolol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chalcones  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chloropicrin  (ISO)
chlorothalonil  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dichloromethane  (ISO)
Didecyldimethylammonium  (ISO)
dieckol  (ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (ISO)
famotidine  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gadodiamide hydrate  (ISO)
gefitinib  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
Glabrene  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
Goe 6976  (ISO)
Heliotrine  (ISO)
hemin  (ISO)
heparin  (ISO)
herbimycin  (ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
homocysteine  (EXP)
HU-308  (ISO)
hyaluronic acid  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
ibuprofen  (ISO)
ilomastat  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cystathionine  (ISO)
L-cysteine  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (EXP,ISO)
loliolide  (ISO)
lucanthone  (ISO)
luteolin  (ISO)
LY294002  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
Methanandamide  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
mevalonic acid  (ISO)
mibolerone  (ISO)
mifepristone  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
moxifloxacin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
norfloxacin  (ISO)
NSC 23766  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PD 0325901  (ISO)
pentanal  (ISO)
peptidoglycan  (ISO)
perfluorodecanoic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphocholine  (ISO)
phosphorylcholine chloride  (ISO)
pifithrin-alpha hydrobromide  (ISO)
platycodin D  (ISO)
polymyxin B2  (ISO)
potassium chromate  (ISO)
Praeruptorin A  (ISO)
progesterone  (ISO)
propanal  (ISO)
protein kinase inhibitor  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
Ruscogenin  (ISO)
Rutecarpine  (ISO)
ruthenium red  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selumetinib  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (ISO)
sotorasib  (ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
thymidine  (ISO)
thymine  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
topotecan  (ISO)
trametinib  (ISO)
Tremulacin  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tubocurarine  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
Ulipristal  (EXP)
Ursonic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanadyl sulfate  (ISO)
varespladib methyl  (ISO)
vemurafenib  (ISO)
vincaleukoblastine  (ISO)
wortmannin  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Local delivery of matrix metalloproteinase gene prevents the onset of renal sclerosis in streptozotocin-induced diabetic mice. Aoyama T, etal., Tissue Eng. 2003 Dec;9(6):1289-99.
2. The involvement of oxidants and NF-kappaB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells. Ben-David D, etal., Inflamm Res. 2012 Jul;61(7):673-88. doi: 10.1007/s00011-012-0461-7. Epub 2012 Mar 13.
3. MMP-1 expression has an independent prognostic value in breast cancer. Bostrom P, etal., BMC Cancer. 2011 Aug 11;11:348. doi: 10.1186/1471-2407-11-348.
4. Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis. Bradbury PA, etal., Carcinogenesis. 2009 May;30(5):793-8. doi: 10.1093/carcin/bgp065. Epub 2009 Mar 25.
5. Low-level laser therapy in experimental model of collagenase-induced tendinitis in rats: effects in acute and chronic inflammatory phases. Casalechi HL, etal., Lasers Med Sci. 2013 May;28(3):989-95. doi: 10.1007/s10103-012-1189-x. Epub 2012 Aug 28.
6. Regulation of collagen degradation in the rat myocardium after infarction. Cleutjens JP, etal., J Mol Cell Cardiol. 1995 Jun;27(6):1281-92.
7. Glomerular Protein Levels of Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 Are Lower in Diabetic Subjects. Cornish TC, etal., J Histochem Cytochem. 2009 Jun 8.
8. Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients. Cozzolino M, etal., Nephrol Dial Transplant. 2009 Jul;24(7):2207-12. doi: 10.1093/ndt/gfp061. Epub 2009 Feb 16.
9. MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population. de Souza AP, etal., J Clin Periodontol. 2003 Feb;30(2):154-8.
10. Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis. Decock J, etal., BMC Cancer. 2008 Mar 20;8:77.
11. Genetic determinants of emphysema distribution in the national emphysema treatment trial. DeMeo DL, etal., Am J Respir Crit Care Med. 2007 Jul 1;176(1):42-8. Epub 2007 Mar 15.
12. [Effect of Bushen Huoxue recipe on the state of extracellular matrix in glomerulosclerosis rats model]. Duan XH, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Nov;30(11):1197-200.
13. Prognostic significance of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in voided urine samples from patients with transitional cell carcinoma of the bladder. Durkan GC, etal., Clin Cancer Res. 2001 Nov;7(11):3450-6.
14. Matrix metalloproteinases in patients with myocardial infarction and percutaneous revascularization. Eckart RE, etal., J Interv Cardiol. 2004 Feb;17(1):27-31.
15. Downregulation of vascular matrix metalloproteinase inducer and activator proteins in hypertensive patients. Ergul A, etal., Am J Hypertens. 2004 Sep;17(9):775-82.
16. A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support. Felkin LE, etal., J Heart Lung Transplant. 2006 Dec;25(12):1413-9.
17. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
18. Differential gene expression of MMP-1, TIMP-1 and HGF in clinically involved and uninvolved skin in South Africans with SSc. Frost J, etal., Rheumatology (Oxford). 2012 Jun;51(6):1049-52. doi: 10.1093/rheumatology/ker367. Epub 2012 Jan 27.
19. Total glucosides of Danggui Buxue Tang attenuates bleomycin-induced pulmonary fibrosis via inhibition of extracellular matrix remodelling. Gao J, etal., J Pharm Pharmacol. 2012 Jun;64(6):811-20. doi: 10.1111/j.2042-7158.2012.01490.x. Epub 2012 Apr 5.
20. [The expressions of TNF-alpha and MMP-9 in serum and MMP-1 mRNA in the bone tissue in chronic obstructive pulmonary disease patients of cold dryness syndrome in northwest China]. Gao Z, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Aug;32(8):1103-6.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Treatment of sheep steroid-induced ocular hypertension with a glucocorticoid-inducible MMP1 gene therapy virus. Gerometta R, etal., Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3042-8. doi: 10.1167/iovs.09-4920. Epub 2010 Jan 20.
23. Matrix metalloproteinase-1 promoter polymorphism 1G/2G is correlated with colorectal cancer invasiveness. Ghilardi G, etal., Clin Cancer Res. 2001 Aug;7(8):2344-6.
24. A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility. Ghilardi G, etal., Clin Cancer Res. 2002 Dec;8(12):3820-3.
25. Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. Ghilardi G, etal., Stroke. 2002 Oct;33(10):2408-12.
26. Varicose veins possess greater quantities of MMP-1 than normal veins and demonstrate regional variation in MMP-1 and MMP-13. Gillespie DL, etal., J Surg Res. 2002 Aug;106(2):233-8.
27. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
28. Changes in matrix metalloproteinases during the evolution of interstitial renal fibrosis in a rat experimental model. Gonzalez-Avila G, etal., Pathobiology. 1998;66(5):196-204.
29. Expression of matrix metalloproteinase-1 (MMP-1) in Wistar rat's intervertebral disc after experimentally induced scoliotic deformity. Grivas TB, etal., Scoliosis. 2011 May 9;6(1):9. doi: 10.1186/1748-7161-6-9.
30. Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices. Guo Y, etal., Clin Exp Pharmacol Physiol. 2010 Dec;37(12):1107-13. doi: 10.1111/j.1440-1681.2010.05450.x.
31. Protective effect of sodium ferulate on acetaldehyde-treated precision-cut rat liver slices. Guo Y, etal., J Med Food. 2012 Jun;15(6):557-62. doi: 10.1089/jmf.2011.1915. Epub 2012 Mar 9.
32. Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis. Handy JA, etal., Biochem J. 2011 Dec 15;440(3):385-95. doi: 10.1042/BJ20102148.
33. Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3). Handy JA, etal., J Cell Biochem. 2010 Aug 1;110(5):1195-207. doi: 10.1002/jcb.22634.
34. Lipodermatosclerosis is characterized by elevated expression and activation of matrix metalloproteinases: implications for venous ulcer formation. Herouy Y, etal., J Invest Dermatol. 1998 Nov;111(5):822-7.
35. Interstitial fibrosis in the heart: differences in extracellular matrix proteins and matrix metalloproteinases in end-stage dilated, ischaemic and valvular cardiomyopathy. Herpel E, etal., Histopathology. 2006 May;48(6):736-47.
36. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter is associated with conventional renal cell carcinoma. Hirata H, etal., Int J Cancer. 2003 Sep 1;106(3):372-4.
37. Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease. Horne BD, etal., Am Heart J. 2007 Oct;154(4):751-8.
38. Protective effects of berberine in an experimental rat osteoarthritis model. Hu PF, etal., Phytother Res. 2011 Jun;25(6):878-85. doi: 10.1002/ptr.3359. Epub 2010 Nov 24.
39. Matrix metalloproteinase-1 polymorphism is associated with persistent airway obstruction in asthma in the Taiwanese population. Huang CD, etal., J Asthma. 2009 Feb;46(1):41-6.
40. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
41. Circulating matrix metalloproteinase-1 and -3 in patients with an acute coronary syndrome. Inoue T, etal., Am J Cardiol. 2003 Dec 15;92(12):1461-4.
42. Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis. Itagaki M, etal., J Clin Periodontol. 2004 Sep;31(9):764-9.
43. Proteolytic cleavage of type I collagen generates an autoantigen in autoimmune uveitis. Jha P, etal., J Biol Chem. 2009 Nov 6;284(45):31401-11. doi: 10.1074/jbc.M109.033381. Epub 2009 Sep 15.
44. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Joos L, etal., Hum Mol Genet. 2002 Mar 1;11(5):569-76.
45. Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis. Kaden JJ, etal., Cardiovasc Pathol. 2005 Mar-Apr;14(2):80-7.
46. Correlation between expression of the matrix metalloproteinase-1 gene in ovarian cancers and an insertion/deletion polymorphism in its promoter region. Kanamori Y, etal., Cancer Res. 1999 Sep 1;59(17):4225-7.
47. Levels of matrix metalloproteinase-1 in patients with and without coronary artery disease and relation to complex and noncomplex coronary plaques. Kato R, etal., Am J Cardiol. 2005 Jan 1;95(1):90-2.
48. Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage. Keeling J and Herrera GA, Kidney Int. 2005 Oct;68(4):1590-603.
49. Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers. Keyszer G, etal., J Rheumatol. 1999 Feb;26(2):251-8.
50. Expression of specific matrix metalloproteinases in inflammatory myopathies. Kieseier BC, etal., Brain. 2001 Feb;124(Pt 2):341-51.
51. Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women. Klinchid J, etal., Cancer Genet Cytogenet. 2009 Dec;195(2):143-9.
52. Evidence for vascular macrophage migration inhibitory factor in destabilization of human atherosclerotic plaques. Kong YZ, etal., Cardiovasc Res. 2005 Jan 1;65(1):272-82.
53. Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections. Koullias GJ, etal., Ann Thorac Surg. 2004 Dec;78(6):2106-10; discussion 2110-1.
54. Matrix metalloproteinase and cytokine profiles in monocytes over the course of stroke. Kouwenhoven M, etal., J Clin Immunol. 2001 Sep;21(5):365-75.
55. Evaluation of enzymes involved in proteoglycan degradation in the wall of abdominal aortic aneurysms. Kowalewski R, etal., J Vasc Res. 2006;43(1):95-100. Epub 2005 Nov 16.
56. CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis. Laragione T, etal., Arthritis Rheum. 2011 Nov;63(11):3274-83. doi: 10.1002/art.30573.
57. The vitamin D receptor regulates rheumatoid arthritis synovial fibroblast invasion and morphology. Laragione T, etal., Mol Med. 2012 Mar 27;18:194-200. doi: 10.2119/molmed.2011.00410.
58. ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis. Lemaitre V, etal., J Clin Invest. 2001 May;107(10):1227-34.
59. Physiological loading of joints prevents cartilage degradation through CITED2. Leong DJ, etal., FASEB J. 2011 Jan;25(1):182-91. Epub 2010 Sep 8.
60. [Effects of yiqi huoxue compound combined with exercise therapy on MMP-1 and collagen type III expressions of cardiac muscle in chronic heart failure rats]. Li H, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Jul;31(7):955-60.
61. Periodontal ligament remodeling and alveolar bone resorption during orthodontic tooth movement in rats with diabetes. Li X, etal., Diabetes Technol Ther. 2010 Jan;12(1):65-73. doi: 10.1089/dia.2009.0085.
62. Functional polymorphisms in matrix metalloproteinases-1, -3, -9 are associated with arteriovenous fistula patency in hemodialysis patients. Lin CC, etal., Clin J Am Soc Nephrol. 2010 Oct;5(10):1805-14. doi: 10.2215/CJN.01500210. Epub 2010 Jul 8.
63. Controlled release of matrix metalloproteinase-1 plasmid DNA prevents left ventricular remodeling in chronic myocardial infarction of rats. Lin X, etal., Circ J. 2009 Dec;73(12):2315-21. Epub 2009 Oct 2.
64. Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression. Liu H, etal., Melanoma Res. 2012 Apr;22(2):169-75. doi: 10.1097/CMR.0b013e32834fc46b.
65. [The expression of matrix metalloproteinase-1 and interleukin-1-alpha messenger ribonucleic acid in human middle ear cholesteatoma]. Liu J, etal., Zhonghua Er Bi Yan Hou Ke Za Zhi. 2002 Feb;37(1):30-3.
66. MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardioversion in patients with persistent atrial fibrillation. Lombardi F, etal., J Cardiovasc Med (Hagerstown). 2011 Jan;12(1):37-42. doi: 10.2459/JCM.0b013e3283403366.
67. Myocardial collagen turnover in hypertrophic cardiomyopathy. Lombardi R, etal., Circulation. 2003 Sep 23;108(12):1455-60. Epub 2003 Sep 2.
68. Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China. Lu Z, etal., J Neurooncol. 2007 Oct;85(1):65-73. Epub 2007 May 15.
69. Analysis of the association of an MMP1 promoter polymorphism and transcript levels with chronic periodontitis and end-stage renal disease in a Brazilian population. Luczyszyn SM, etal., Arch Oral Biol. 2012 Jul;57(7):954-63. doi: 10.1016/j.archoralbio.2012.01.013. Epub 2012 Mar 7.
70. Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction. Lui PP, etal., Eur Cell Mater. 2013 Jan 16;25:78-96.
71. Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia. Mairuae N, etal., Neurosci Lett. 2011 Aug 1;500(1):36-40. doi: 10.1016/j.neulet.2011.06.001. Epub 2011 Jun 12.
72. Matrix metalloproteinases and their impact on sinusal extension in chronic rhinosinusitis with nasal polyps. Malinsky RR, etal., Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1345-8. doi: 10.1007/s00405-012-2219-9. Epub 2012 Oct 12.
73. Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency. McAloon CJ, etal., Ther Adv Respir Dis. 2009 Feb;3(1):23-30.
74. Benzopyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells. Meng D, etal., Toxicol Lett. 2009 Jan 10;184(1):44-9. doi: 10.1016/j.toxlet.2008.10.016. Epub 2008 Oct 28.
75. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
76. Polymorphisms in matrix metalloproteinases MMP1 and MMP9 are associated with primary open-angle and angle closure glaucoma in a Pakistani population. Micheal S, etal., Mol Vis. 2013;19:441-7. Epub 2013 Feb 20.
77. The MMP1 (-16071G/2G) single nucleotide polymorphism associates with the HAART-related lipodystrophic syndrome. Montes AH, etal., AIDS. 2010 Oct 23;24(16):2499-506. doi: 10.1097/QAD.0b013e32833e922c.
78. Differences in matrix metalloproteinase-1 and matrix metalloproteinase-12 transcript levels among carotid atherosclerotic plaques with different histopathological characteristics. Morgan AR, etal., Stroke. 2004 Jun;35(6):1310-5. Epub 2004 Apr 8.
79. Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas. Mossbock G, etal., Mol Vis. 2010 Aug 28;16:1764-70.
80. Elevation of serum levels of metalloproteinase-1, tissue inhibitor of metalloproteinase-1 and type IV collagen, and plasma levels of metalloproteinase-9 in polycystic kidney disease. Nakamura T, etal., Am J Nephrol. 2000 Jan-Feb;20(1):32-6.
81. A polymorphism at -1607 2G in the matrix metalloproteinase-1 (MMP-1) increased risk of sudden deafness in Korean population but not at -519A/G in MMP-1. Nam SI, etal., Laryngoscope. 2011 Jan;121(1):171-5. doi: 10.1002/lary.21334.
82. Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Niebroj-Dobosz I, etal., Eur J Neurol. 2010 Feb;17(2):226-31. doi: 10.1111/j.1468-1331.2009.02775.x. Epub 2009 Oct 1.
83. A relationship between Matrix metalloproteinase-1 (MMP-1) promoter polymorphism and cervical cancer progression. Nishioka Y, etal., Cancer Lett. 2003 Oct 8;200(1):49-55.
84. Collagenase, gelatinase, and proteoglycanase messenger ribonucleic acid expression and activity during luteal development, maintenance, and regression in the pseudopregnant rat ovary. Nothnick WB, etal., Biol Reprod. 1996 Mar;54(3):616-24.
85. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
86. Haplotype effect of the matrix metalloproteinase-1 gene on risk of myocardial infarction. Pearce E, etal., Circ Res. 2005 Nov 11;97(10):1070-6. Epub 2005 Oct 6.
87. Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies. Peng B, etal., Mutagenesis. 2010 Jan;25(1):41-8. doi: 10.1093/mutage/gep041. Epub 2009 Oct 20.
88. Lack of association between matrix metalloproteinase-1 (MMP-1) promoter polymorphism and risk of renal cell carcinoma. Piccoli MF, etal., Int Braz J Urol. 2007 Sep-Oct;33(5):622-9.
89. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
90. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
91. ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat. Podesser BK, etal., Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H984-91.
92. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
93. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
94. Comprehensive gene review and curation RGD comprehensive gene curation
95. MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. Rosas IO, etal., PLoS Med. 2008 Apr 29;5(4):e93.
96. KITENIN is associated with tumor progression in human gastric cancer. Ryu HS, etal., Anticancer Res. 2010 Sep;30(9):3479-86.
97. Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk. Schabath MB, etal., Am J Epidemiol. 2005 Mar 1;161(5):412-22.
98. Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy. Schwartzkopff B, etal., Eur J Heart Fail. 2002 Aug;4(4):439-4.
99. Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1. Shi ZD, etal., Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1225-34. doi: 10.1152/ajpheart.00369.2009. Epub 2009 May 22.
100. Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism. Shi ZD, etal., Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H127-35. doi: 10.1152/ajpheart.00732.2009. Epub 2009 Oct 30.
101. Expression of metalloproteinases and interleukins on anastomoses in septic rats. Silva SM, etal., J Surg Res. 2013 Aug;183(2):777-82. doi: 10.1016/j.jss.2013.02.012. Epub 2013 Mar 4.
102. Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis. So JS, etal., Life Sci. 2011 Feb 14;88(7-8):358-66. doi: 10.1016/j.lfs.2010.12.013. Epub 2010 Dec 16.
103. Cathepsin C, matrix metalloproteinases, and their tissue inhibitors in gingiva and gingival crevicular fluid from periodontitis-affected patients. Soell M, etal., J Dent Res. 2002 Mar;81(3):174-8.
104. Enhanced angiotensin II-mediated effects in fibroblasts of patients with familial hypercholesterolemia. Solini A, etal., J Hypertens. 2005 Feb;23(2):367-74.
105. Nanoparticle-mediated local delivery of an antisense TGF-beta1 construct inhibits intimal hyperplasia in autogenous vein grafts in rats. Sun DX, etal., PLoS One. 2012;7(7):e41857. doi: 10.1371/journal.pone.0041857. Epub 2012 Jul 30.
106. A single-nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances bladder cancer susceptibility. Tasci AI, etal., BJU Int. 2008 Feb;101(4):503-7. Epub 2007 Nov 6.
107. A frequent functional SNP in the MMP1 promoter is associated with higher disease severity in recessive dystrophic epidermolysis bullosa. Titeux M, etal., Hum Mutat. 2008 Feb;29(2):267-76.
108. Maternal hypoxia alters matrix metalloproteinase expression patterns and causes cardiac remodeling in fetal and neonatal rats. Tong W, etal., Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2113-21. doi: 10.1152/ajpheart.00356.2011. Epub 2011 Aug 19.
109. The association of serum matrix metalloproteinases and their tissue inhibitor levels with scleroderma disease severity. Toubi E, etal., Clin Exp Rheumatol. 2002 Mar-Apr;20(2):221-4.
110. Ibuprofen upregulates expressions of matrix metalloproteinase-1, -8, -9, and -13 without affecting expressions of types I and III collagen in tendon cells. Tsai WC, etal., J Orthop Res. 2010 Apr;28(4):487-91. doi: 10.1002/jor.21009.
111. Decreased matrix metalloproteinase activity in the kidneys of hereditary nephrotic mice (ICGN strain). Uchio K, etal., Nephron. 2000 Oct;86(2):145-51.
112. Extracellular matrix disturbances in acute myocardial infarction: relation between disease severity and matrix metalloproteinase-1, and effects of magnesium pretreatment on reperfusion injury. Ueshima K, etal., Magnes Res. 2003 Jun;16(2):120-6.
113. Increased expression of matrix metalloproteinases in the murine zymosan-induced multiple organ dysfunction syndrome. Volman TJ, etal., J Pathol. 2004 Aug;203(4):968-75.
114. Promoter polymorphisms in matrix metallopeptidase 1 and risk of cutaneous melanoma. Wang LE, etal., Eur J Cancer. 2011 Jan;47(1):107-15. doi: 10.1016/j.ejca.2010.06.129. Epub 2010 Jul 23.
115. [Effects of electroacupuncture at Jiaji (EX-B 2) on extracellular matrix MMP-1, MMP-3 and TIMP-1 levels in the degenerated cervical intervertebral disc in rats]. Wang XX, etal., Zhen Ci Yan Jiu. 2009 Aug;34(4):248-51.
116. Protective effect of ilomastat on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats. Wang YD and Wang W, World J Gastroenterol. 2008 Oct 7;14(37):5683-8.
117. Therapeutic effects of p75 tumor necrosis factor receptor monoclonal antibody on a rat model of traumatic arthritis. Wang YX, etal., J Surg Res. 2014 Jan;186(1):234-9. doi: 10.1016/j.jss.2013.07.047. Epub 2013 Aug 20.
118. Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families. Wojciechowski R, etal., Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4989-95. doi: 10.1167/iovs.10-5474. Epub 2010 May 19.
119. Effect of hyperglycemia on apoptosis of notochordal cells and intervertebral disc degeneration in diabetic rats. Won HY, etal., J Neurosurg Spine. 2009 Dec;11(6):741-8. doi: 10.3171/2009.6.SPINE09198.
120. [Precondition with doxycycline administration abates ischemia/reperfusion injury and reduces the expression of matrix metalloproteinase-1/9 in myocardium in rat in vivo]. Wu LM, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 Nov;19(11):679-82.
121. Chemical analysis of Hericium erinaceum polysaccharides and effect of the polysaccharides on derma antioxidant enzymes, MMP-1 and TIMP-1 activities. Xu H, etal., Int J Biol Macromol. 2010 Jul 1;47(1):33-6. doi: 10.1016/j.ijbiomac.2010.03.024. Epub 2010 Apr 7.
122. [Anti-angiogenic effects of genistein on synovium in a rat model of type II collagen-induced arthritis]. Xu JX, etal., Zhong Xi Yi Jie He Xue Bao. 2011 Feb;9(2):186-93.
123. Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis. Yang E, etal., Cancer Res. 2009 Aug 1;69(15):6223-31. doi: 10.1158/0008-5472.CAN-09-0187. Epub 2009 Jul 21.
124. Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro. Yang L, etal., Exp Mol Med. 2009 Jul 31;41(7):508-16. doi: 10.3858/emm.2009.41.7.056.
125. Effect of Danshao Huaxian capsule on expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in fibrotic liver of rats. Yang Q, etal., World J Gastroenterol. 2005 Aug 28;11(32):4953-6.
126. Matrix metalloproteinase-1 induces cleavage of exogenous alphaB-crystallin transduced by a cell-penetrating peptide. Yang SW, etal., J Cell Biochem. 2011 Sep;112(9):2454-62. doi: 10.1002/jcb.23167.
127. Simvastatin attenuates pulmonary vascular remodelling by down-regulating matrix metalloproteinase-1 and -9 expression in a carotid artery-jugular vein shunt pulmonary hypertension model in rats. Yao J, etal., Eur J Cardiothorac Surg. 2012 Nov;42(5):e121-7. doi: 10.1093/ejcts/ezs445.
128. Variation in the matrix metalloproteinase-1 gene and risk of coronary heart disease. Ye S, etal., Eur Heart J. 2003 Sep;24(18):1668-71.
129. Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage. Zhang B, etal., Stroke. 2001 Sep;32(9):2198-202.
130. Diagnostic value of platelet derived growth factor-BB, transforming growth factor-beta1, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosis. Zhang BB, etal., World J Gastroenterol. 2003 Nov;9(11):2490-6.
131. NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. Zhang C, etal., Antioxid Redox Signal. 2010 Oct 1;13(7):975-86. doi: 10.1089/ars.2010.3091.
132. Alterations of collagen-I, MMP-1 and TIMP-1 in the periodontal ligament of diabetic rats under mechanical stress. Zhang L, etal., J Periodontal Res. 2011 Aug;46(4):448-55. doi: 10.1111/j.1600-0765.2011.01359.x. Epub 2011 Apr 13.
133. [Expression and significance of matrix metalloproteinase-1,9, tissue inhibitor of metalloproteinase-4 and extracellular matrix metalloproteinase inducer in the myocardium of congestive heart failure in patients with rheumatic heart diseases]. Zhao Y, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Aug;34(8):790-5.
134. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. Zhu Y, etal., Cancer Res. 2001 Nov 1;61(21):7825-9.
Additional References at PubMed
PMID:8605638   PMID:9920899   PMID:11113146   PMID:12118097   PMID:12477932   PMID:14504039   PMID:15652546   PMID:15863497   PMID:16047157   PMID:17275272   PMID:17607299   PMID:17989988  
PMID:19022250   PMID:19250650   PMID:20923679   PMID:21342246   PMID:21637818   PMID:23086831   PMID:23845380   PMID:25073870   PMID:26087281   PMID:26191209   PMID:27339256   PMID:28220578  
PMID:28626073   PMID:32072839   PMID:32538742   PMID:33356628   PMID:38643908  


Genomics

Comparative Map Data
Mmp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8812,943,453 - 12,963,966 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl812,943,453 - 12,963,964 (+)EnsemblGRCr8
mRatBN7.284,658,588 - 4,679,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,658,588 - 4,679,097 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx88,618,256 - 8,638,758 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,916,028 - 6,936,530 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,918,249 - 4,938,764 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,703,206 - 5,723,593 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,703,206 - 5,723,591 (+)Ensemblrn6Rnor6.0
Rnor_5.085,706,054 - 5,726,441 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.484,333,773 - 4,354,284 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera86,218,410 - 6,238,921 (+)NCBICelera
RGSC_v3.184,333,814 - 4,353,725 (+)NCBI
Cytogenetic Map8q11NCBI
MMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,789,919 - 102,798,160 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,789,401 - 102,798,160 (-)Ensemblhg38GRCh38
GRCh3711102,660,650 - 102,668,891 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,165,861 - 102,174,104 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411102,165,860 - 102,174,104NCBI
Celera1199,822,300 - 99,830,624 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,588,616 - 98,596,940 (-)NCBIHuRef
CHM1_111102,543,487 - 102,551,813 (-)NCBICHM1_1
T2T-CHM13v2.011102,793,739 - 102,801,980 (-)NCBIT2T-CHM13v2.0
Mmp1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,367,670 - 7,388,026 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,368,239 - 7,388,047 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3897,367,670 - 7,388,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,368,239 - 7,388,047 (-)Ensemblmm10GRCm38
MGSCv3797,367,670 - 7,388,026 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3697,368,237 - 7,387,993 (-)NCBIMGSCv36mm8
Celera94,767,814 - 4,788,756 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
MMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,583,360 - 103,592,135 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,671,553 - 104,680,228 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,730,545 - 97,739,190 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,221,393 - 101,230,104 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,221,393 - 101,230,104 (-)EnsemblpanPan2panpan1.1
MMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,978,385 - 28,986,644 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,978,473 - 28,986,648 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha528,926,897 - 28,935,120 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0529,029,643 - 29,038,059 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,029,685 - 29,075,950 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,064,653 - 29,073,076 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0528,944,064 - 28,952,288 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,119,065 - 29,127,510 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mmp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,361,179 - 86,368,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,168,044 - 5,174,857 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,167,909 - 5,175,149 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,411,065 - 33,420,076 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1933,411,738 - 33,420,205 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,358,454 - 37,367,107 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,167,507 - 94,177,357 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,167,219 - 94,176,767 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604331,701,312 - 31,710,000 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462487871,642 - 79,602 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462487871,642 - 79,660 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmp1
125 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:53
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000012595
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
AU049293  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.284,663,853 - 4,664,063 (+)MAPPERmRatBN7.2
Rnor_6.085,708,472 - 5,708,681NCBIRnor6.0
Rnor_5.085,711,320 - 5,711,529UniSTSRnor5.0
RGSC_v3.484,339,039 - 4,339,248UniSTSRGSC3.4
Celera86,223,676 - 6,223,885UniSTS
Cytogenetic Map8q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
2 1 25 16 11 4 16 4 2 38 28 1 13 4 48 7

Sequence


Ensembl Acc Id: ENSRNOT00000012595   ⟹   ENSRNOP00000012595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl812,943,453 - 12,963,964 (+)Ensembl
mRatBN7.2 Ensembl84,658,588 - 4,679,097 (+)Ensembl
Rnor_6.0 Ensembl85,703,206 - 5,723,591 (+)Ensembl
RefSeq Acc Id: NM_001134530   ⟹   NP_001128002
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8812,943,453 - 12,963,966 (+)NCBI
mRatBN7.284,658,588 - 4,679,099 (+)NCBI
Rnor_6.085,703,206 - 5,723,593 (+)NCBI
Rnor_5.085,706,054 - 5,726,441 (+)NCBI
RGSC_v3.484,333,773 - 4,354,284 (+)RGD
Celera86,218,410 - 6,238,921 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128002 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69019 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012595
GenBank Protein P81563 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001128002   ⟸   NM_001134530
- Peptide Label: precursor
- UniProtKB: B5DFD5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012595   ⟸   ENSRNOT00000012595
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFD5-F1-model_v2 AlphaFold B5DFD5 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307917 AgrOrtholog
BioCyc Gene G2FUF-31788 BioCyc
Ensembl Genes ENSRNOG00000032353 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012595 ENTREZGENE
NCBI Gene 300339 ENTREZGENE
PhenoGen Mmp1 PhenoGen
RatGTEx ENSRNOG00000032353 RatGTEx
UniProt B5DFD5 ENTREZGENE, UniProtKB/TrEMBL
  MMP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-04 Mmp1  matrix metallopeptidase 1  Mmp1  matrix metallopeptidase 1 (interstitial collagenase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-27 Mmp1  matrix metallopeptidase 1 (interstitial collagenase)  Mmp1a  matrix metallopeptidase 1a (interstitial collagenase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mmp1a  matrix metallopeptidase 1a (interstitial collagenase)   Mmp1a_predicted  matrix metallopeptidase 1a (interstitial collagenase) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Mmp1a_predicted  matrix metallopeptidase 1a (interstitial collagenase) (predicted)    matrix metalloproteinase 1a (interstitial collagenase) (predicted)  Name updated 1299863 APPROVED
2005-01-12 Mmp1a_predicted  matrix metalloproteinase 1a (interstitial collagenase) (predicted)      Symbol and Name status set to approved 70820 APPROVED