RGD Reference Report - Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk. - Rat Genome Database

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Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk.

Authors: Schabath, MB  Delclos, GL  Martynowicz, MM  Greisinger, AJ  Lu, C  Wu, X  Spitz, MR 
Citation: Schabath MB, etal., Am J Epidemiol. 2005 Mar 1;161(5):412-22.
RGD ID: 5131088
Pubmed: PMID:15718477   (View Abstract at PubMed)
DOI: DOI:10.1093/aje/kwi063   (Journal Full-text)

The authors compared histories of nonmalignant respiratory diseases (asthma, bronchitis, emphysema, hay fever, and pneumonia) in 1,553 lung cancer patients and 1,375 healthy controls enrolled in a Texas case-control study from 1995 to 2003. They incorporated data on two biologically relevant polymorphic genes, matrix metalloproteinase-1 and myeloperoxidase. Emphysema was associated with a statistically significant increased lung cancer risk (odds ratio (OR) = 2.87, 95% confidence interval (CI): 2.20, 3.76), while hay fever had a significant protective effect (OR = 0.58, 95% CI: 0.48, 0.70). Odds ratios were consistent after exclusion of respiratory disease diagnoses made up to 10 years before interview. There was little association between other respiratory diseases and lung cancer risk. Among carriers of "protective" genotypes, emphysema was associated with a 1.7-fold increased risk (95% CI: 0.84, 3.50), as compared with the substantially higher risk for persons possessing one (OR = 4.98, 95% CI: 2.94, 8.44) or two (OR = 4.23, 95% CI: 1.84, 9.73) "adverse" genotypes. For hay fever, significantly decreased risks were evident with one (OR = 0.32, 95% CI: 0.21, 0.50) or two (OR = 0.35, 95% CI: 0.19, 0.66) protective genotypes as compared with none (OR = 0.69, 95% CI: 0.30, 1.59). The biologic role of respiratory disease in lung cancer is unclear. Further study may yield new insights for identification of susceptible subgroups.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lung cancer  IAGP 5131088; 5131088associated with Respiratory Tract DiseasesRGD 
lung cancer  ISOMMP1 (Homo sapiens)5131088; 5131088associated with Respiratory Tract DiseasesRGD 
lung cancer  ISOMPO (Homo sapiens)5131088; 5131088associated with Respiratory Tract DiseasesRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp1  (matrix metallopeptidase 1)
Mpo  (myeloperoxidase)

Genes (Mus musculus)
Mmp1a  (matrix metallopeptidase 1a (interstitial collagenase))
Mpo  (myeloperoxidase)

Genes (Homo sapiens)
MMP1  (matrix metallopeptidase 1)
MPO  (myeloperoxidase)


Additional Information