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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307917 Species: Rattus norvegicus RGD Object: Gene Symbol: Mmp1 Name: matrix metallopeptidase 1 (interstitial collagenase)

Acc ID: CHEBI:100241 Term: ciprofloxacin Definition: Quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively. CasRN: 85721-33-1 Chemical ID: MESH:D002939

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1317388	6480464	CTD	Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]	PMID:16148020 PMID:12428247
multiple interactions	ISO	RGD:1317388	6480464	CTD	Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]	PMID:12428247 PMID:16148020
multiple interactions	ISO	RGD:1317388	6480464	CTD	Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]	PMID:16148020
increases expression	ISO	RGD:1317388	6480464	CTD	Ciprofloxacin results in increased expression of MMP1 mRNA	PMID:12428247