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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp1
Name: matrix metallopeptidase 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp1decreases expressionISOMMP1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of MMP1 mRNAPMID:15761015 PMID:23253724
Mmp1multiple interactionsISOMMP1 (Homo sapiens)6480464CTD[acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased activity of MMP1 protein; [acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased expression of MMP1 mRNA; [acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased secretion of MMP1 protein; Arsenic Trioxide inhibits the reaction [TNF protein results in increased expression of MMP1 mRNA]; Arsenic Trioxide inhibits the reaction [TNF protein results in increased secretion of and results in increased activity of MMP1 protein]PMID:21078271 PMID:23253724
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