RGD Reference Report - Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage. - Rat Genome Database

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Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage.

Authors: Zhang, B  Dhillon, S  Geary, I  Howell, WM  Iannotti, F  Day, IN  Ye, S 
Citation: Zhang B, etal., Stroke. 2001 Sep;32(9):2198-202.
RGD ID: 1582365
Pubmed: PMID:11546917   (View Abstract at PubMed)

BACKGROUND AND PURPOSE: Intracranial aneurysm, which underlies the vast majority of subarachnoid hemorrhage incidences, has a multifactorial etiology, and the importance of genetic factors is increasingly recognized. Development and rupture of intracranial aneurysms involve degradation and remodeling of the vascular wall matrix in which the matrix metalloproteinases (MMPs) play an important role. The possible impact of MMP gene polymorphisms on susceptibility to intracranial aneurysms is still controversial, with conflicting data from different reported studies. METHODS: In this study we analyzed 5 different functional promoter polymorphisms in the MMP-1, MMP-3, MMP-9, and MMP-12 genes in a sample of 92 patients with aneurysmal subarachnoid hemorrhage and 158 healthy control subjects, all from southern England. RESULTS: No significant difference was detected between the patient and control groups in genotype distribution of any of the polymorphisms studied. CONCLUSIONS: The data do not support the hypothesis that MMP gene variations influence the development of intracranial aneurysms in the population studied.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
intracranial aneurysm no_associationIAGP 1582365 RGD 
intracranial aneurysm no_associationISOMMP12 (Homo sapiens)1582365; 1582365 RGD 
Subarachnoid Hemorrhage no_associationIAGP 1582365 RGD 
Subarachnoid Hemorrhage no_associationISOMMP1 (Homo sapiens)1582365; 1582365 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp1  (matrix metallopeptidase 1)
Mmp12  (matrix metallopeptidase 12)

Genes (Mus musculus)
Mmp12  (matrix metallopeptidase 12)
Mmp1a  (matrix metallopeptidase 1a (interstitial collagenase))

Genes (Homo sapiens)
MMP1  (matrix metallopeptidase 1)
MMP12  (matrix metallopeptidase 12)


Additional Information