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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp1
Name: matrix metallopeptidase 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp1decreases expressionISOMMP1 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of MMP1 mRNAPMID:25047013
Mmp1decreases secretionISOMMP1 (Homo sapiens)6480464CTDDexamethasone results in decreased secretion of MMP1 proteinPMID:15698539
Mmp1multiple interactionsISOMMP1 (Homo sapiens)6480464CTDDexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in decreased secretion of MMP1 protein]PMID:15698539 PMID:20858459
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