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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307917 Species: Rattus norvegicus RGD Object: Gene Symbol: Mmp1 Name: matrix metallopeptidase 1 (interstitial collagenase)

Acc ID: CHEBI:29865 Term: benzo[a]pyrene Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. CasRN: 50-32-8 Chemical ID: MESH:D001564

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1317388	6480464	CTD	Benzo(a)pyrene results in increased expression of MMP1 mRNA	PMID:15808406 PMID:18061397
multiple interactions	EXP		6480464	CTD	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP1 mRNA]	PMID:19022365
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of MMP1 mRNA	PMID:19022365
increases expression	ISO	RGD:1317388	6480464	CTD	Benzo(a)pyrene results in increased expression of MMP1 mRNA	PMID:18061397 PMID:15808406
increases expression	ISO	RGD:1317388	6480464	CTD	Benzo(a)pyrene results in increased expression of MMP1 mRNA	PMID:18061397 PMID:15808406 PMID:21871943
increases expression	ISO	RGD:1317388	6480464	CTD	Benzo(a)pyrene results in increased expression of MMP1 mRNA	PMID:15808406 PMID:18061397 PMID:21871943
increases expression	ISO	RGD:1317388	6480464	CTD	Benzo(a)pyrene results in increased expression of MMP1 mRNA	PMID:21871943 PMID:15808406 PMID:18061397
increases expression	ISO	RGD:1317389	6480464	CTD	Benzo(a)pyrene results in increased expression of MMP1A mRNA	PMID:22228805
increases expression	ISO	RGD:1317388	6480464	CTD	Benzo(a)pyrene results in increased expression of MMP1 protein	PMID:22581694
increases expression	ISO	RGD:1317388	6480464	CTD	Benzo(a)pyrene results in increased expression of MMP1 mRNA	PMID:15808406 PMID:18061397 PMID:21871943 PMID:22581694