A2m (alpha-2-macroglobulin) - Rat Genome Database

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Gene: A2m (alpha-2-macroglobulin) Rattus norvegicus
Analyze
Symbol: A2m
Name: alpha-2-macroglobulin
RGD ID: 2004
Description: Enables endopeptidase inhibitor activity; identical protein binding activity; and neurotrophin binding activity. Involved in several processes, including acute inflammatory response; embryonic liver development; and response to prostaglandin E. Located in extracellular space. Used to study hemolytic anemia and toxic shock syndrome. Biomarker of several diseases, including liver disease (multiple); membranous glomerulonephritis; osteonecrosis; peritonitis; and trypanosomiasis. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; Alzheimer's disease pathway; immune response pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (S)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A2m1; A2maa; A2MAC1; A2mb; AI893533; alpha-2-M; alpha-2-macroglobulin-like; alpha-2-macroglobulin-P; LOC100911545; Mam; MGC114358; RATA2MAC1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Plsm2  
Candidate Gene For: Plsm2 Bp353
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84156,570,163 - 156,619,870 (+)NCBIGRCr8
mRatBN7.24154,897,770 - 154,947,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4154,897,877 - 154,947,786 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4161,158,697 - 161,208,341 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04156,942,158 - 156,991,802 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04155,571,666 - 155,634,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04154,309,426 - 154,359,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,309,426 - 154,359,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,423,209 - 154,472,924 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04221,393,233 - 221,442,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44158,103,711 - 158,153,423 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14158,348,624 - 158,398,358 (+)NCBI
Celera4143,730,195 - 143,781,190 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-amphetamine  (EXP)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-aminohexanoate  (ISO)
6-aminohexanoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
7-NITROINDAZOLE  (EXP)
acrylamide  (ISO)
Actein  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
antimony(0)  (ISO)
apigenin  (EXP)
arotinoid acid  (ISO)
arsenous acid  (ISO)
bacitracin  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carnosic acid  (ISO)
CHIR 99021  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (ISO)
cholate  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycidyl methacrylate  (ISO)
herbicide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (EXP)
isoniazide  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
melamine  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N(6),N(6)-dimethyladenine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
naphthalene  (EXP,ISO)
nickel atom  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
olanzapine  (ISO)
orphenadrine  (EXP)
ouabain  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
prednisone  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrethrins  (EXP)
pyrogallol  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
XAV939  (ISO)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Role of prostaglandins in acute phase proteins in inflammation. Anbalagan K and Sadique J, Biochem Med. 1984 Apr;31(2):236-45.
2. Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat. Andrejko KM, etal., Am J Physiol. 1998 Dec;275(6 Pt 1):G1423-9.
3. Carbon dioxide pneumoperitoneum alters acute-phase response induced by lipopolysaccharide. Are C, etal., Surg Endosc. 2002 Oct;16(10):1464-7. Epub 2002 Jun 4.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Cancer-related anemia in a rat model: alpha2-macroglobulin from Yoshida sarcoma shortens erythrocyte survival. Bhanushali AA, etal., Eur J Haematol 2002 Jan;68(1):42-8.
6. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Blacker D, etal., Nat Genet 1998 Aug;19(4):357-60.
7. Alpha 2 macroglobulin activity in rats infected with Typanosoma lewisi and treated with cyclophosphamide and its effect on the malignancy of the disease. Budovsky A, etal., J Vector Borne Dis. 2007 Jun;44(2):128-36.
8. Association of alpha 2-macroglobulin polymorphisms and Alzheimer disease in Mainland Han Chinese. Chen D, etal., J Neurol Sci. 2004 Jan 15;217(1):13-5.
9. Gene expression profiles of livers from thermally injured rats. Dasu MR, etal., Gene. 2004 Feb 18;327(1):51-60.
10. Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK. Dow DJ, etal., Nat Genet 1999 May;22(1):16-7; author reply 21-2.
11. The development of rat alpha 2-macroglobulin. Studies in vivo and in cultured fetal rat hepatocytes. Fletcher S, etal., Eur J Biochem. 1988 Feb 1;171(3):703-9.
12. Hormonal regulation and tissue-specific localization of alpha 2-macroglobulin in rat ovarian follicles and corpora lutea. Gaddy-Kurten D, etal., Endocrinology. 1989 Dec;125(6):2985-95.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Alpha 2-macroglobulin synthesis in an astrocyte subpopulation. Gebicke-Haerter PJ, etal., J Neurochem. 1987 Oct;49(4):1139-45.
15. Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA. Gehring MR, etal., J Biol Chem 1987 Jan 5;262(1):446-54.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis. Gori AM, etal., J Cereb Blood Flow Metab. 2017 Sep;37(9):3253-3261. doi: 10.1177/0271678X17695572. Epub 2017 Mar 7.
18. 6-sulphanilamidoindazole arthritis of rats: relation between acute-phase proteins, degree of arthritis and treatment with soybean trypsin inhibitor. Hirschelmann R, etal., Agents Actions. 1980 Nov;10(5):431-4.
19. Isolation of bona fide differentially expressed genes in the 18-hour sepsis liver by suppression subtractive hybridization. Hsieh YC, etal., Shock. 2004 Jun;21(6):549-55.
20. Disorders of vesicles of lysosomal lineage: the Hermansky-Pudlak syndromes. Huizing M and Gahl WA, Curr Mol Med. 2002 Aug;2(5):451-67.
21. Suppression of experimental allergic encephalomyelitis by alpha 2-macroglobulin. Hunter N, etal., Immunology. 1991 May;73(1):58-63.
22. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
23. Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model. Kendrick JE, etal., Gynecol Oncol. 2008 Mar;108(3):591-7. Epub 2008 Jan 4.
24. New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model. Kerachian MA, etal., Arthritis Res Ther. 2010;12(3):R124. doi: 10.1186/ar3062. Epub 2010 Jun 25.
25. Kupffer cell stimulation of alpha 2-macroglobulin synthesis in rat hepatocytes and the role of glucocorticoid. Kurokawa S, etal., Cell Struct Funct. 1987 Feb;12(1):35-42.
26. Ontology searching and browsing at the Rat Genome Database. Laulederkind SJ, etal., Database (Oxford). 2012 Mar 20;2012:bas016. Print 2012.
27. Induction and modulation of acute-phase response by protein malnutrition in rats: comparative effect of systemic and localized inflammation on interleukin-6 and acute-phase protein synthesis. Lyoumi S, etal., J Nutr. 1998 Feb;128(2):166-74.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. Purification and properties of rat alpha 2 acute-phase macroglobulin. Nieuwenhuizen W, etal., Biochim Biophys Acta. 1979 Sep 29;580(1):129-39.
32. Structure and acute-phase regulation of the rat alpha 2-macroglobulin gene. Northemann W, etal., Biochemistry 1988 Dec 27;27(26):9194-203.
33. Molecular cloning of cDNA sequences for rat alpha 2-macroglobulin and measurement of its transcription during experimental inflammation. Northemann W, etal., J Biol Chem 1985 May 25;260(10):6200-5.
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. The Rat Genome Database pathway portal. Petri V, etal., Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. Detection of an alteration of the alpha 2-macroglobulin gene in a patient with chronic lung disease and serum alpha 2-macroglobulin deficiency. Poller W, etal., Hum Genet 1989 Aug;83(1):93-6.
39. alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons. Qiu Z, etal., J Biol Chem 2002 Apr 26;277(17):14458-66.
40. Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart. Rajan S, etal., Basic Res Cardiol 2003 Feb;98(1):39-49.
41. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Comprehensive gene review and curation RGD comprehensive gene curation
46. Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Saunders AJ, etal., Hum Mol Genet. 2003 Nov 1;12(21):2765-76. Epub 2003 Sep 9.
47. No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis. Schweer D, etal., J Neuroimmunol 2001 Aug 30;118(2):300-3.
48. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
49. No genetic association between alpha-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimer's disease. Shibata N, etal., Neurosci Lett. 2000 Aug 25;290(2):154-6.
50. Transplacental transport of alpha 2-macroglobulin (alpha 2M) and induction of alpha 2M in maternal and neonatal rats with acute inflammation. Shimizu M, etal., Exp Anim. 2002 Jul;51(4):361-5.
51. Comparative binding of biotinylated neurotrophins to alpha(2)-macroglobulin family of proteins: relationship between cytokine-binding and neuro-modulatory activities of the macroglobulins. Skornicka EL, etal., J Neurosci Res. 2002 Feb 1;67(3):346-53.
52. Beneficial effects of Psidium guajava leaf extract on diabetic myocardium. Soman S, etal., Exp Toxicol Pathol. 2013 Jan;65(1-2):91-5. doi: 10.1016/j.etp.2011.06.005. Epub 2011 Jul 13.
53. Role of nitric oxide in the regulation of activity of proteinase inhibitors alpha(1)-antitrypsin and alpha(2)-macroglobulin by capsaicin-sensitive nerves. Spiridonov VK and Tolochko ZS, Bull Exp Biol Med. 2008 Sep;146(3):375-8.
54. Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are increased in hypoalbuminemia by post-transcriptional mechanisms. Stevenson FT, etal., Kidney Int. 1998 Jan;53(1):67-75.
55. Cardiac isoform of alpha 2 macroglobulin and its reliability as a cardiac marker in HIV patients. Subbiah R, etal., Heart Lung Circ. 2010 Feb;19(2):93-5. doi: 10.1016/j.hlc.2009.10.005. Epub 2009 Dec 11.
56. alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. Sukata T, etal., Am J Pathol 2004 Nov;165(5):1479-88.
57. Alpha-2 macroglobulin I1000 V polymorphism in Chinese sporadic Alzheimer's disease and Parkinson's disease. Tang G, etal., Neurosci Lett. 2002 Aug 9;328(2):195-7.
58. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
59. Sequence analysis of the putative regulatory region of rat alpha 2-macroglobulin gene. Tsuchiya Y, etal., Gene 1987;57(1):73-80.
60. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
61. Alpha 2 macroglobulin of the rat, an acute phase protein, mitigates the early course of endotoxin shock. van Vugt H, etal., Br J Exp Pathol. 1986 Jun;67(3):313-9.
62. Fever and acute phase reactants in the rat. van Vugt H, etal., Br J Exp Pathol. 1988 Aug;69(4):577-88.
63. Alpha-2-macroglobulin and albumin are useful serum proteins to detect subclinical peritonitis in the rat. van Westrhenen R, etal., Perit Dial Int. 2006 Jan-Feb;26(1):101-7.
64. Improvement of visual acuity in patients suffering from diabetic retinopathy after membrane differential filtration: a pilot study. Widder RA, etal., Transfus Sci. 1999 Dec;21(3):201-6.
Additional References at PubMed
PMID:1725450   PMID:2414291   PMID:2466233   PMID:2473946   PMID:9398211   PMID:9714181   PMID:10880251   PMID:11435418   PMID:12223092   PMID:12477932   PMID:12538697   PMID:15226301  
PMID:15272003   PMID:15489334   PMID:17071617   PMID:17487688   PMID:17565389   PMID:18485748   PMID:18701465   PMID:19796622   PMID:20458337   PMID:20848291   PMID:21188621   PMID:21362503  
PMID:21642630   PMID:21669904   PMID:22516433   PMID:23376485   PMID:23533145   PMID:26746007   PMID:26895739   PMID:27301375   PMID:29476059   PMID:36894970  


Genomics

Comparative Map Data
A2m
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84156,570,163 - 156,619,870 (+)NCBIGRCr8
mRatBN7.24154,897,770 - 154,947,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4154,897,877 - 154,947,786 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4161,158,697 - 161,208,341 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04156,942,158 - 156,991,802 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04155,571,666 - 155,634,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04154,309,426 - 154,359,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,309,426 - 154,359,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,423,209 - 154,472,924 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04221,393,233 - 221,442,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44158,103,711 - 158,153,423 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14158,348,624 - 158,398,358 (+)NCBI
Celera4143,730,195 - 143,781,190 (+)NCBICelera
Cytogenetic Map4q42NCBI
A2M
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38129,067,708 - 9,116,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl129,067,664 - 9,116,229 (-)EnsemblGRCh38hg38GRCh38
GRCh37129,220,304 - 9,268,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,111,571 - 9,159,825 (-)NCBINCBI36Build 36hg18NCBI36
Build 34129,111,576 - 9,159,754NCBI
Celera1210,757,430 - 10,805,676 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef129,000,837 - 9,049,088 (-)NCBIHuRef
CHM1_1129,189,284 - 9,237,532 (-)NCBICHM1_1
T2T-CHM13v2.0129,049,893 - 9,098,416 (-)NCBIT2T-CHM13v2.0
A2m
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396121,612,920 - 121,656,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6121,612,335 - 121,656,186 (+)EnsemblGRCm39 Ensembl
GRCm386121,636,165 - 121,679,238 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6121,635,376 - 121,679,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv376121,586,191 - 121,629,256 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366121,593,574 - 121,644,846 (+)NCBIMGSCv36mm8
MGSCv366122,445,338 - 122,497,328 (+)NCBIMGSCv36mm8
Celera6123,474,284 - 123,517,770 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.49NCBI
LOC102021956
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554136,019,082 - 6,062,529 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554136,019,457 - 6,062,366 (+)NCBIChiLan1.0ChiLan1.0
LOC100979269
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21014,596,200 - 14,644,826 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,592,959 - 14,641,585 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0129,154,457 - 9,202,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,385,359 - 9,434,011 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,385,359 - 9,433,979 (-)Ensemblpanpan1.1panPan2
A2M
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,654,328 - 36,695,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,920,641 - 9,962,291 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,002,478 - 37,044,674 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,002,374 - 37,044,672 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12736,883,699 - 36,925,608 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,918,717 - 36,960,000 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0279,452,043 - 9,493,920 (-)NCBIUU_Cfam_GSD_1.0
LOC101959212
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,303,198 - 98,346,620 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936870424,951 - 468,167 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936870424,832 - 468,303 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
A2M
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,440,810 - 62,483,678 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,406,928 - 62,483,690 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,274,903 - 65,320,342 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in A2m
209 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000019346
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat

Markers in Region
D4Mit20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24154,902,669 - 154,902,892 (+)MAPPERmRatBN7.2
Rnor_6.04154,314,020 - 154,314,242NCBIRnor6.0
Rnor_6.04154,427,762 - 154,427,984NCBIRnor6.0
Rnor_5.04221,510,881 - 221,511,103UniSTSRnor5.0
Rnor_5.04221,397,827 - 221,398,049UniSTSRnor5.0
RGSC_v3.44158,108,304 - 158,108,528RGDRGSC3.4
RGSC_v3.44158,108,305 - 158,108,527UniSTSRGSC3.4
RGSC_v3.14158,353,240 - 158,353,464RGD
Celera4143,736,074 - 143,736,296UniSTS
Celera4143,734,692 - 143,736,296UniSTS
RH 3.4 Map4997.54RGD
RH 3.4 Map4997.54UniSTS
RH 2.0 Map41012.9RGD
Cytogenetic Map4q42UniSTS
D4Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24154,896,195 - 154,896,338 (+)MAPPERmRatBN7.2
Rnor_6.04154,421,288 - 154,421,430NCBIRnor6.0
Rnor_6.04154,307,546 - 154,307,688NCBIRnor6.0
Rnor_5.04221,504,407 - 221,504,549UniSTSRnor5.0
Rnor_5.04221,391,353 - 221,391,495UniSTSRnor5.0
RGSC_v3.44158,101,830 - 158,101,973RGDRGSC3.4
RGSC_v3.44158,101,831 - 158,101,973UniSTSRGSC3.4
RGSC_v3.14158,346,766 - 158,346,909RGD
Celera4143,728,315 - 143,728,457UniSTS
RH 3.4 Map4997.91UniSTS
RH 3.4 Map4997.91RGD
Cytogenetic Map4q42UniSTS
D4Arb15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24154,896,113 - 154,896,328 (+)MAPPERmRatBN7.2
Rnor_6.04154,307,464 - 154,307,678NCBIRnor6.0
Rnor_6.04154,421,206 - 154,421,420NCBIRnor6.0
Rnor_5.04221,391,271 - 221,391,485UniSTSRnor5.0
Rnor_5.04221,504,325 - 221,504,539UniSTSRnor5.0
RGSC_v3.44158,101,748 - 158,101,963RGDRGSC3.4
RGSC_v3.44158,101,749 - 158,101,963UniSTSRGSC3.4
RGSC_v3.14158,346,684 - 158,346,899RGD
Celera4143,728,233 - 143,728,447UniSTS
RH 3.4 Map4997.5UniSTS
RH 3.4 Map4997.5RGD
RH 2.0 Map4989.4RGD
SHRSP x BN Map475.9499RGD
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 22 22 1
Low 2 11 10 1 10 23 29
Below cutoff 15 6 13 6 1 1 51 15 11 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY887133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY919611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY921651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000019346   ⟹   ENSRNOP00000019346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4154,897,877 - 154,947,786 (+)Ensembl
Rnor_6.0 Ensembl4154,309,426 - 154,359,137 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075799   ⟹   ENSRNOP00000066130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4154,899,373 - 154,945,739 (+)Ensembl
Rnor_6.0 Ensembl4154,423,209 - 154,472,924 (+)Ensembl
RefSeq Acc Id: NM_012488   ⟹   NP_036620
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84156,570,163 - 156,619,870 (+)NCBI
mRatBN7.24154,898,076 - 154,947,787 (+)NCBI
Rnor_6.04154,309,426 - 154,359,138 (+)NCBI
Rnor_5.04221,393,233 - 221,442,945 (+)NCBI
RGSC_v3.44158,103,711 - 158,153,423 (+)RGD
Celera4143,730,195 - 143,781,190 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036620   ⟸   NM_012488
- Peptide Label: precursor
- UniProtKB: Q4FZY3 (UniProtKB/Swiss-Prot),   P06238 (UniProtKB/Swiss-Prot),   A6ILD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019346   ⟸   ENSRNOT00000019346
RefSeq Acc Id: ENSRNOP00000066130   ⟸   ENSRNOT00000075799
Protein Domains
Alpha-2-macroglobulin   Alpha-2-macroglobulin bait region   Alpha-macroglobulin receptor-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06238-F1-model_v2 AlphaFold P06238 1-1472 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2004 AgrOrtholog
BioCyc Gene G2FUF-43173 BioCyc
Ensembl Genes ENSRNOG00000028896 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000045772 Ensembl
Ensembl Transcript ENSRNOT00000019346 ENTREZGENE
  ENSRNOT00000019346.7 UniProtKB/Swiss-Prot
  ENSRNOT00000075799.3 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.20.130.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.1540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1930 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1940 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7458629 IMAGE-MGC_LOAD
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_TED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglob_thiol-ester_cl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MacrogloblnA2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24153 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114358 IMAGE-MGC_LOAD
NCBI Gene 24153 ENTREZGENE
PANTHER ALPHA-2-MACROGLOBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MACROGLOBULIN / COMPLEMENT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A2M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TED_complement UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen A2m PhenoGen
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028896 RatGTEx
  ENSRNOG00000045772 RatGTEx
SMART A2M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiol-ester_cl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229016
  TC239648
UniProt A0A8L2QY59_RAT UniProtKB/TrEMBL
  A2MG_RAT UniProtKB/Swiss-Prot
  A6ILD0 ENTREZGENE, UniProtKB/TrEMBL
  A6ILD1_RAT UniProtKB/TrEMBL
  A6ILD2_RAT UniProtKB/TrEMBL
  P06238 ENTREZGENE
  Q4FZY3 ENTREZGENE
UniProt Secondary Q4FZY3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 A2m  alpha-2-macroglobulin  LOC100911545  alpha-2-macroglobulin-like  Data merged from RGD:6492449 737654 PROVISIONAL
2012-07-05 LOC100911545  alpha-2-macroglobulin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-16 A2m    A2m1  alpha-2-macroglobulin  Symbol updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 A2m  alpha-2-macroglobulin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression may be induced during the regeneration of hepatocytes after liver damage 67925
gene_expression may be induced during the regeneration of hepatocytes after liver damage 70249
gene_process has a role in the acute-phase response to tissue damage and infection 67925
gene_process has a role in the acute-phase response to tissue damage and infection 70249
gene_process inhibits proteinases 67925
gene_process inhibits proteinases 70249