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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2004
Species: Rattus norvegicus
RGD Object: Gene
Symbol: A2m
Name: alpha-2-macroglobulin
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
A2maffects expressionISOA2M (Homo sapiens)6480464CTDValproic Acid affects the expression of A2M mRNAPMID:25979313
A2mdecreases expressionISOA2M (Homo sapiens)6480464CTDValproic Acid results in decreased expression of A2M mRNAPMID:29154799 PMID:29501571
A2mdecreases methylationISOA2M (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of A2M genePMID:29154799
A2mincreases expressionISOA2M (Homo sapiens)6480464CTDValproic Acid results in increased expression of A2M mRNAPMID:28001369
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