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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2004
Species: Rattus norvegicus
RGD Object: Gene
Symbol: A2m
Name: alpha-2-macroglobulin
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
A2maffects expressionEXP 6480464CTDbisphenol A affects the expression of A2M mRNAPMID:25181051 PMID:32145629
A2mdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of A2M mRNAPMID:34947998
A2mincreases expressionEXP 6480464CTDbisphenol A results in increased expression of A2M mRNAPMID:30816183
A2maffects expressionISOA2M (Homo sapiens)6480464CTDbisphenol A affects the expression of A2M mRNAPMID:30903817
A2mdecreases expressionISOA2m (Mus musculus)6480464CTDbisphenol A results in decreased expression of A2M mRNAPMID:32156529 PMID:35479511
A2mincreases expressionISOA2m (Mus musculus)6480464CTDbisphenol A results in increased expression of A2ML1 mRNA; bisphenol A results in increased expression of PZP mRNAPMID:30245210 PMID:32156529
A2mincreases methylationISOA2m (Mus musculus)6480464CTDbisphenol A results in increased methylation of A2M promoter; bisphenol A results in increased methylation of A2ML1 promoterPMID:27312807
A2mmultiple interactionsISOA2M (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of A2M mRNAPMID:28628672
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