RGD Reference Report - Role of nitric oxide in the regulation of activity of proteinase inhibitors alpha(1)-antitrypsin and alpha(2)-macroglobulin by capsaicin-sensitive nerves. - Rat Genome Database

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Role of nitric oxide in the regulation of activity of proteinase inhibitors alpha(1)-antitrypsin and alpha(2)-macroglobulin by capsaicin-sensitive nerves.

Authors: Spiridonov, VK  Tolochko, ZS 
Citation: Spiridonov VK and Tolochko ZS, Bull Exp Biol Med. 2008 Sep;146(3):375-8.
RGD ID: 7411612
Pubmed: PMID:19240864   (View Abstract at PubMed)

Regulation of activity of serine proteinase inhibitor a1-antitrypsin and nonspecific proteinase inhibitor alpha(2)-macroglobulin in the blood by nitric oxide was studied in intact rats and animals with damage to capsaicin-sensitive nerves. Nonselective nitric oxide synthase inhibitor L-NAME produced a dose-dependent increase in alpha(1)-antitrypsin activity in intact animals. Neuronal NO synthase inhibitor 7-nitroindazole increased alpha(2)-macroglobulin activity. Deafferentation with capsaicin was followed by a decrease in alpha(1)-antitrypsin activity. Both inhibitors of nitric oxide synthase increased activity of alpha(1)-antitrypsin in capsaicin-receiving rats. Nitric oxide precursor L-arginine had a normalizing effect on reduced activity of alpha(1)-antitrypsin after capsaicin deafferentation. Our results suggest that nitric oxide has a modulatory effect on activity of proteinase inhibitors and is involved in the effector influence of capsaicin-sensitive nerves on alpha(1)-antitrypsin activity.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of endopeptidase activity  IDA 7411612 RGD 
negative regulation of serine-type endopeptidase activity  IDA 7411612 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endopeptidase inhibitor activity  IDA 7411612 RGD 
serine-type endopeptidase inhibitor activity  IDA 7411612 RGD 

Objects Annotated

Genes (Rattus norvegicus)
A2m  (alpha-2-macroglobulin)
Serpina1  (serpin family A member 1)


Additional Information