RGD Reference Report - Cardiac isoform of alpha 2 macroglobulin and its reliability as a cardiac marker in HIV patients. - Rat Genome Database

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Cardiac isoform of alpha 2 macroglobulin and its reliability as a cardiac marker in HIV patients.

Authors: Subbiah, R  Chengat, V  Clifton, JD  Rathinavel, A  Bidulescu, A  Tharmarajan, R  Selvam, GS 
Citation: Subbiah R, etal., Heart Lung Circ. 2010 Feb;19(2):93-5. doi: 10.1016/j.hlc.2009.10.005. Epub 2009 Dec 11.
RGD ID: 10046031
Pubmed: PMID:20005173   (View Abstract at PubMed)
DOI: DOI:10.1016/j.hlc.2009.10.005   (Journal Full-text)

BACKGROUND: Cardiac isoform of alpha 2 macroglobulin (CA2M), a serum protein (182000Mr) has been used as a diagnostic molecular marker for cardiac manifestations in HIV and diabetic patients. This study investigates the reliability of CA2M as an early diagnostic marker for cardiac manifestations in HIV patients and factors that could possibly influence their levels. METHODS: A total of 206 serum samples were analysed from HIV patients with cardiac diseases (68), with non-cardiac ailments (48), opportunistic infections (34) and without other co-morbidities (56). The immuno-cross-reactivity between human serum CA2M and anti-rat CA2M antibody was tested and quantified by sandwich enzyme linked immunosorbent assay (ELISA). RESULTS: The CA2M levels were high in HIV patients with cardiac diseases irrespective of the manifestations. The CA2M levels were not influenced by opportunistic infections, non-cardiac ailments and patient parameters like age, sex, duration of illness, past history of other co-morbidities. CONCLUSION: CA2M can be used as a reliable early diagnostic marker in HIV patients with cardiac manifestations. CA2M levels were not influenced by other patient parameters.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
heart disease  IEP 10046031associated with HIV Infections and protein:increased expression:serumRGD 
heart disease  ISOA2M (Homo sapiens)10046031; 10046031associated with HIV Infections and protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
A2m  (alpha-2-macroglobulin)

Genes (Mus musculus)
A2m  (alpha-2-macroglobulin)

Genes (Homo sapiens)
A2M  (alpha-2-macroglobulin)


Additional Information