RGD Reference Report - Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat. - Rat Genome Database

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Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat.

Authors: Andrejko, KM  Chen, J  Deutschman, CS 
Citation: Andrejko KM, etal., Am J Physiol. 1998 Dec;275(6 Pt 1):G1423-9.
RGD ID: 1598509
Pubmed: PMID:9843780   (View Abstract at PubMed)

Interleukin-6 (IL-6) regulates hepatic acute phase responses by activating the transcription factor signal transducer and activator of transcription (STAT)-3. IL-6 also may modulate septic pathophysiology. We hypothesize that 1) STAT-3 activation and transcription of alpha2-macroglobulin (A2M) correlate with recovery from sepsis and 2) STAT-3 activation and A2M transcription reflect intrahepatic and not serum IL-6. Nonlethal sepsis was induced in rats by single puncture cecal ligation and puncture (CLP) and lethal sepsis via double-puncture CLP. STAT-3 activation and A2M transcription were detected at 3-72 h and intrahepatic IL-6 at 24-72 h following single-puncture CLP. All were detected only at 3-16 h following double-puncture CLP and at lower levels than following single-puncture CLP. Loss of serum and intrahepatic IL-6 activity after double-puncture CLP correlated with mortality. Neither intrahepatic nor serum IL-6 levels correlated with intrahepatic IL-6 activity. STAT-3 activation following single-puncture CLP inversely correlated with altered transcription of gluconeogenic, ketogenic, and ureagenic genes. IL-6 may have both beneficial and detrimental effects in sepsis. Fulminant sepsis may decrease the ability of hepatocytes to respond to IL-6.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Sepsis  ISOA2m (Rattus norvegicus)1598509; 1598509 RGD 
Sepsis  IEP 1598509 RGD 

Objects Annotated

Genes (Rattus norvegicus)
A2m  (alpha-2-macroglobulin)

Genes (Mus musculus)
A2m  (alpha-2-macroglobulin)

Genes (Homo sapiens)
A2M  (alpha-2-macroglobulin)


Additional Information