RGD Reference Report - 6-sulphanilamidoindazole arthritis of rats: relation between acute-phase proteins, degree of arthritis and treatment with soybean trypsin inhibitor. - Rat Genome Database

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6-sulphanilamidoindazole arthritis of rats: relation between acute-phase proteins, degree of arthritis and treatment with soybean trypsin inhibitor.

Authors: Hirschelmann, R  Schade, R  Bekemeier, H 
Citation: Hirschelmann R, etal., Agents Actions. 1980 Nov;10(5):431-4.
RGD ID: 10046032
Pubmed: PMID:6163339   (View Abstract at PubMed)

During 6-sulphanilamidoindazole (6-SAI) arthritis a significant increase of serum levels of the protease inhibitor alpha 2 macroglobulin (= alpha 2 acute phase globulin) and of Darcy's glycoprotein was found, whereas the content of female specific protein and of sulfhydryl groups was proved to be significantly decreased. Intravenous administration of 5 mg/kg soybean trypsin inhibitor, twice daily for 4 days, was without any inhibitory effect on paw swelling in 6-SAI arthritis but it caused increased serum levels of alpha 2 macroglobulin and Darcy's glycoprotein. Thus, spontaneous remission of 6-SAI arthritis occurring, despite continued administration of 6-SAI, seems hardly likely to be caused by acute-phase reactants, e.g. via protease inhibition. Evidence is presented which shows that spontaneous remission of 6-SAI arthritis could be due to local processes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Arthritis  ISOA2m (Rattus norvegicus)10046032; 10046032protein:increased expression:serumRGD 
Experimental Arthritis  IEP 10046032protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
A2m  (alpha-2-macroglobulin)

Genes (Mus musculus)
A2m  (alpha-2-macroglobulin)

Genes (Homo sapiens)
A2M  (alpha-2-macroglobulin)


Additional Information