Igf1r (insulin-like growth factor 1 receptor) - Rat Genome Database

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Gene: Igf1r (insulin-like growth factor 1 receptor) Rattus norvegicus
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Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
RGD ID: 2869
Description: Enables G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor receptor activity. Involved in several processes, including cellular response to ketone; cellular response to peptide hormone stimulus; and negative regulation of apoptotic process. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); carcinoma (multiple); diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and toxic encephalopathy. Orthologous to human IGF1R (insulin like growth factor 1 receptor); PARTICIPATES IN insulin-like growth factor signaling pathway; E-cadherin signaling pathway; endocytosis pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (S)-nicotine; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IGF-1 receptor; IGF-I receptor; IGFIRC; Igfr1; insulin-like growth factor I receptor; JTK13; type-I IGF receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHRSP.WKY-(Igf1r-D1Rat36)/IzmTkyo
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81130,959,787 - 131,248,664 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1130,959,997 - 131,248,664 (+)EnsemblGRCr8
mRatBN7.21121,549,831 - 121,838,548 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1121,550,743 - 121,831,777 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1129,548,259 - 129,834,935 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01136,718,334 - 137,005,027 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01129,519,288 - 129,805,989 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01128,924,921 - 129,213,816 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1128,924,966 - 129,206,516 (+)Ensemblrn6Rnor6.0
Rnor_5.01129,985,761 - 130,272,589 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41122,704,976 - 122,990,007 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1113,751,636 - 114,029,884 (+)NCBICelera
RGSC_v3.11122,783,318 - 123,068,350 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP)
adrenocortical carcinoma  (ISO)
alcoholic neuropathy  (IEP)
Alzheimer's disease  (IEP,IMP,ISO)
amyotrophic lateral sclerosis  (IEP)
atrial fibrillation  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Burns  (IEP)
Cardiomegaly  (ISO)
cardiomyopathy  (IEP)
Carotid Artery Injuries  (IEP)
Choroidal Neovascularization  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital diaphragmatic hernia  (ISO)
coronary stenosis  (IEP)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
cryptorchidism  (IEP)
dementia  (ISO)
Desbuquois dysplasia  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (IEP)
Dwarfism  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP)
fetal alcohol spectrum disorder  (IEP)
Fetal Growth Retardation  (IEP,ISO)
gastrinoma  (ISO)
gastroschisis  (IEP)
genetic disease  (ISO)
gestational diabetes  (IEP)
Graves' disease  (ISO)
Growth Disorders  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperphagia  (IMP)
hypertension  (IEP)
hyperthyroidism  (IEP)
hypertrophic cardiomyopathy  (ISO)
IgA glomerulonephritis  (ISO)
IGF1R-RELATED DISORDER  (ISO)
intellectual disability  (ISO)
juvenile rheumatoid arthritis  (ISO)
keratoconus  (ISO)
Kidney Reperfusion Injury  (IEP)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
lung disease  (ISO)
Malocclusion  (IEP)
Metabolic Bone Diseases  (IEP)
metabolic dysfunction-associated steatotic liver disease  (IEP)
myeloid neoplasm  (ISO)
myocardial infarction  (IEP)
NATURAL KILLER CELL ENTEROPATHY  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (IEP)
Optic Nerve Injuries  (IEP,IMP)
osteoarthritis  (ISO)
osteoporosis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (IMP,ISO)
peripheral nervous system disease  (ISO)
portal vein thrombosis  (ISO)
Premature Aging  (ISO)
prostate adenocarcinoma  (IMP,ISO)
prostate cancer  (ISO)
prostate carcinoma  (IEP)
prostatic hypertrophy  (ISO)
Pulmonary Arterial Hypertension  (IEP)
renal cell carcinoma  (IEP)
respiratory failure  (ISO)
Right Ventricular Hypertrophy  (IDA)
Skin Neoplasms  (ISO)
stroke  (ISO)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (IEP)
ulcerative colitis  (ISO)
vascular dementia  (ISO)
vesicoureteral reflux  (ISO)
Zollinger-Ellison syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
(Z)-ligustilide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-Di-O-caffeoylquinic acid  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5,6,7,8-tetrahydrofolic acid  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
acetazolamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amino acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
AP20187  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
Azoxymethane  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Bisphenol Z  (ISO)
BMS-754807  (EXP,ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
Chimaphylin  (ISO)
chitin  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP)
cisplatin  (ISO)
clodronic acid  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
dapsone  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dihydrofolic acid  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
diquat  (ISO)
Doramectin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enzacamene  (EXP)
enzalutamide  (ISO)
equol  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
everolimus  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (EXP,ISO)
gallic acid  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
glucose  (ISO)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
herbicide  (EXP)
hexachlorobenzene  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (EXP)
isoflurane  (EXP)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
leuprolide  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP)
lovastatin  (EXP)
lycopene  (ISO)
manganese(II) chloride  (EXP)
maslinic acid  (ISO)
masoprocol  (ISO)
melatonin  (EXP)
menadione  (ISO)
metformin  (EXP,ISO)
methcathinone  (ISO)
methimazole  (EXP,ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (EXP,ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (EXP,ISO)
Myrtucommulone A  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-phosphocreatine  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
nicotine  (EXP)
nilutamide  (EXP)
nitrofen  (EXP)
nitrogen mustard  (ISO)
ochratoxin A  (EXP)
Octicizer  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picolinic acid  (EXP)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
piperine  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
propiconazole  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
RU 58668  (ISO)
rutin  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sophoraflavanone B  (EXP)
sorafenib  (ISO)
soybean oil  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tanespimycin  (EXP,ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
amyloid-beta clearance  (ISO)
animal organ morphogenesis  (ISO)
axonogenesis  (IMP)
brain development  (ISO)
cardiac atrium development  (IEP)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to aldosterone  (IEP)
cellular response to amyloid-beta  (ISO)
cellular response to angiotensin  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to glucose stimulus  (IBA,IEA,IEP,ISO)
cellular response to insulin stimulus  (IEA,IEP,ISO)
cellular response to insulin-like growth factor stimulus  (IEP,IPI)
cellular response to mechanical stimulus  (IEP)
cellular response to progesterone stimulus  (IEP)
cellular response to testosterone stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IPI)
cellular response to zinc ion starvation  (IEP)
cellular senescence  (IEP)
cerebellum development  (IEP,IMP)
dendritic spine maintenance  (IGI)
epidermis development  (ISO)
establishment of cell polarity  (IMP)
estrous cycle  (IMP)
exocrine pancreas development  (ISO)
hippocampus development  (IEP)
immune response  (ISO)
insulin receptor signaling pathway  (IBA,IMP)
insulin-like growth factor receptor signaling pathway  (IBA,IEA,ISO,ISS)
male sex determination  (ISO)
mammary gland development  (ISO)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of cholangiocyte apoptotic process  (IMP)
negative regulation of hepatocyte apoptotic process  (IMP)
negative regulation of MAPK cascade  (ISO,ISS)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
neuron projection development  (IDA)
obsolete negative regulation of DNA-binding transcription factor activity  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
positive regulation of axon regeneration  (IMP)
positive regulation of cell cycle process  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytokinesis  (IMP)
positive regulation of developmental growth  (ISO)
positive regulation of DNA metabolic process  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of meiotic cell cycle  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IEA,IMP,ISO)
positive regulation of protein-containing complex disassembly  (IGI)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of steroid hormone biosynthetic process  (IMP)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prostate gland epithelium morphogenesis  (ISO)
protein autophosphorylation  (ISO,ISS)
protein phosphorylation  (ISO)
regulation of JNK cascade  (IBA,ISO,ISS)
response to alkaloid  (IEP)
response to ethanol  (IDA,IEP)
response to hormone  (IEP)
response to insulin  (IEP)
response to L-glutamate  (IDA)
response to nicotine  (IEP)
response to nutrient levels  (IEP)
response to vitamin E  (IEP)
transcytosis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. Abuzzahab MJ, etal., N Engl J Med. 2003 Dec 4;349(23):2211-22.
2. IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer. Aleksic T, etal., Br J Cancer. 2017 Nov 21;117(11):1600-1606. doi: 10.1038/bjc.2017.337. Epub 2017 Oct 3.
3. Effect of testicular damage induced by cryptorchidism on insulin-like growth factor I receptors in rat Sertoli cells. Antich M, etal., J Reprod Fertil. 1995 Jul;104(2):267-75.
4. Myocardial infarction and the myocyte IGF1 autocrine system. Anversa P, etal., Eur Heart J. 1995 Dec;16 Suppl N:37-45.
5. Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine. Araujo AS, etal., Mol Cell Biochem. 2007 Sep;303(1-2):89-95. Epub 2007 Apr 20.
6. Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition. Bielen A, etal., Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1267-76. doi: 10.1073/pnas.1105034109. Epub 2012 Apr 23.
7. IGF-I binding proteins, IGF-I binding protein mRNA and IGF-I receptor mRNA in rats with acute renal failure given IGF-I. Bohe J, etal., Kidney Int. 1998 Oct;54(4):1070-82.
8. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Broyl A, etal., Lancet Oncol. 2010 Nov;11(11):1057-65. Epub 2010 Sep 21.
9. Expression of insulin-like growth factor 1 receptor in rat retina following optic nerve injury. Bu SY, etal., Acta Ophthalmol. 2013 Sep;91(6):e427-31. doi: 10.1111/aos.12096. Epub 2013 May 7.
10. The role of gut-liver axis in the restriction of intrauterine growth in a model of experimental gastroschisis. Bueno MP, etal., Acta Cir Bras. 2013;28 Suppl 1:3-7.
11. Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo. Burfeind P, etal., Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7263-8.
12. Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes. Calderari S, etal., Diabetologia. 2007 Jul;50(7):1463-71. Epub 2007 May 3.
13. Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease? Carro E, etal., Neurobiol Aging. 2006 Nov;27(11):1618-31. Epub 2005 Nov 7.
14. Insulin-like growth factor-1 receptor polymorphism and ischemic stroke: a case-control study in Chinese population. Cheng J, etal., Acta Neurol Scand. 2008 Nov;118(5):333-8. Epub 2008 May 9.
15. Insulin-like growth factor-1 expression in reflux nephropathy. Chertin B, etal., Pediatr Surg Int. 2004 Apr;20(4):283-9. Epub 2004 Feb 4.
16. Progesterone and dexamethasone differentially regulate the IGF-system in glial cells. Chesik D and De Keyser J, Neurosci Lett. 2010 Jan 14;468(3):178-82. doi: 10.1016/j.neulet.2009.10.051. Epub 2009 Oct 22.
17. Enhancement of AG1024-induced H9c2 cardiomyoblast cell apoptosis via the interaction of IGF2R with Galpha proteins and its downstream PKA and PLC-beta modulators by IGF-II. Chu CH, etal., Chin J Physiol. 2009 Feb 28;52(1):31-7.
18. Region-specific alterations in insulin-like growth factor receptor type I in the cerebral cortex and hippocampus of aged rats. Chung YH, etal., Brain Res 2002 Aug 16;946(2):307-13.
19. Age-related upregulation of insulin-like growth factor receptor type I in rat cerebellum. Chung YH, etal., Neurosci Lett 2002 Sep 13;330(1):65-8.
20. Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model. Cohen AC, etal., Alcohol Clin Exp Res. 2007 Sep;31(9):1558-73. Epub 2007 Jul 11.
21. Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development. Colon E, etal., Endocrinology. 2007 Jan;148(1):128-39. Epub 2006 Oct 5.
22. Shared pathways of osteoblast mitogenesis induced by amylin, adrenomedullin, and IGF-1. Cornish J, etal., Biochem Biophys Res Commun. 2004 May 21;318(1):240-6.
23. Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice. Corrochano S, etal., PLoS One. 2014 Aug 20;9(8):e105595. doi: 10.1371/journal.pone.0105595. eCollection 2014.
24. Astrocytes regulate the expression of insulin-like growth factor 1 receptor (IGF1-R) in primary cortical neurons during in vitro senescence. Costantini C, etal., J Mol Neurosci. 2010 Mar;40(3):342-52. doi: 10.1007/s12031-009-9305-5. Epub 2009 Oct 28.
25. si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder. de la Monte SM, etal., Mol Brain. 2011 Mar 28;4:13. doi: 10.1186/1756-6606-4-13.
26. Nicotine-induced retardation of chondrogenesis through down-regulation of IGF-1 signaling pathway to inhibit matrix synthesis of growth plate chondrocytes in fetal rats. Deng Y, etal., Toxicol Appl Pharmacol. 2013 May 15;269(1):25-33. doi: 10.1016/j.taap.2013.02.008. Epub 2013 Feb 27.
27. Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome proliferator-activated receptor gamma2. Dieudonne MN, etal., Endocrinology. 2000 Feb;141(2):649-56.
28. Renal carcinogenesis in models of diabetes in rats: metabolic changes are closely related to neoplastic development. Dombrowski F, etal., Diabetologia. 2007 Dec;50(12):2580-90. Epub 2007 Oct 19.
29. Decreased expression of Wilms' tumor gene WT-1 and elevated expression of insulin growth factor-II (IGF-II) and type 1 IGF receptor genes in prostatic stromal cells from patients with benign prostatic hyperplasia. Dong G, etal., J Clin Endocrinol Metab. 1997 Jul;82(7):2198-203.
30. B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. Douglas RS, etal., J Immunol. 2008 Oct 15;181(8):5768-74.
31. Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 system. Drudi Metalli V, etal., Dig Liver Dis. 2007 Jul;39(7):654-62. Epub 2007 May 24.
32. G-protein and tyrosine kinase receptor cross-talk in rat aortic smooth muscle cells: thrombin- and angiotensin II-induced tyrosine phosphorylation of insulin receptor substrate-1 and insulin-like growth factor 1 receptor. Du J, etal., Biochem Biophys Res Commun. 1996 Jan 26;218(3):934-9.
33. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
34. The insulin-like growth factor 1 receptor is essential for axonal regeneration in adult central nervous system neurons. Dupraz S, etal., PLoS One. 2013;8(1):e54462. doi: 10.1371/journal.pone.0054462. Epub 2013 Jan 18.
35. Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor. Economou MA, etal., Acta Ophthalmol. 2008 Nov;86 Thesis 4:42-9. doi: 10.1111/j.1755-3768.2008.01185.x.
36. Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. Freude S, etal., FASEB J. 2009 Oct;23(10):3315-24. doi: 10.1096/fj.09-132043. Epub 2009 Jun 1.
37. Increased expression of insulin-like growth factor I and/or its receptor in gastrinomas is associated with low curability, increased growth, and development of metastases. Furukawa M, etal., Clin Cancer Res. 2005 May 1;11(9):3233-42.
38. Association of insulin-like growth factor-1 receptor polymorphism in dementia. Garcia J, etal., Dement Geriatr Cogn Disord. 2006;22(5-6):439-44. Epub 2006 Sep 15.
39. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
40. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
41. Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta. Gårdebjer EM, etal., Placenta. 2014 Jan;35(1):50-7. doi: 10.1016/j.placenta.2013.10.008. Epub 2013 Nov 5.
42. The effects of induced type-I diabetes on developmental regulation of insulin & insulin like growth factor-1 (IGF-1) receptors in the cerebellum of rat neonates. Haghir H, etal., Metab Brain Dis. 2013 Sep;28(3):397-410. doi: 10.1007/s11011-013-9386-2. Epub 2013 Feb 10.
43. Polymorphisms of insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) contribute to pathologic progression in childhood IgA nephropathy. Hahn WH, etal., Growth Factors. 2011 Feb;29(1):8-13. doi: 10.3109/08977194.2010.532126. Epub 2010 Nov 4.
44. Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. Hakam A, etal., Dig Dis Sci. 2003 Oct;48(10):1972-8.
45. Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes. Hallak H, etal., Hepatology 2002 Dec;36(6):1509-18.
46. Sex differences and left-right asymmetries in expression of insulin and insulin-like growth factor-1 receptors in developing rat hippocampus. Hami J, etal., Brain Struct Funct. 2012 Apr;217(2):293-302. doi: 10.1007/s00429-011-0358-1. Epub 2011 Nov 1.
47. The effects of maternal diabetes on expression of insulin-like growth factor-1 and insulin receptors in male developing rat hippocampus. Hami J, etal., Brain Struct Funct. 2013 Jan;218(1):73-84. doi: 10.1007/s00429-011-0377-y. Epub 2012 Jan 13.
48. Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells. Hayashi K, etal., J Biol Chem. 2004 Sep 24;279(39):40807-18. Epub 2004 Jul 21.
49. Insulin-like growth factor-1 receptor expression in the placentae of diabetic and normal pregnancies. Hayati AR, etal., Early Hum Dev. 2007 Jan;83(1):41-6. Epub 2006 Jun 5.
50. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
51. Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation. Hie M, etal., Int J Mol Med. 2011 Sep;28(3):455-62. doi: 10.3892/ijmm.2011.697. Epub 2011 May 11.
52. Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate. Huynh H, etal., J Endocrinol 2001 Oct;171(1):109-18.
53. Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors. Ibarra C, etal., Circ Res. 2013 Jan 18;112(2):236-45. doi: 10.1161/CIRCRESAHA.112.273839. Epub 2012 Nov 1.
54. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Isshiki K, etal., Kidney Int. 2008 Dec;74(11):1434-43. doi: 10.1038/ki.2008.403. Epub 2008 Aug 13.
55. Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61.
56. Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor. Kato H, etal., Biochem Biophys Res Commun. 2015 May 22;461(1):115-21. doi: 10.1016/j.bbrc.2015.03.178. Epub 2015 Apr 7.
57. Premature aging in vitamin D receptor mutant mice. Keisala T, etal., J Steroid Biochem Mol Biol. 2009 Jul;115(3-5):91-7. doi: 10.1016/j.jsbmb.2009.03.007. Epub 2009 Mar 31.
58. Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Kim J, etal., Mol Endocrinol. 2008 Nov;22(11):2531-43. Epub 2008 Sep 18.
59. The potential role of IGF-I receptor mRNA in rats with diabetic retinopathy. Kuang H, etal., Chin Med J (Engl). 2003 Mar;116(3):478-80.
60. [The relationship of blood glucose and the expression of insulin-like growth factor-1 receptor mRNA in diabetic cardiomyopathy: a preliminary study with rats] Kuang HY, etal., Zhonghua Yi Xue Za Zhi. 2007 May 15;87(18):1249-51.
61. Insulin-like growth factor-I and its receptor in neovascular age-related macular degeneration. Lambooij AC, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):2192-8.
62. Disruption of growth hormone secretion alters Ca2+ current density and expression of Ca2+ channel and insulin-like growth factor genes in rat atria. Larsen JK, etal., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H829-38. Epub 2004 Oct 14.
63. Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor. Liu G, etal., Exp Cell Res. 2011 Oct 15;317(17):2420-8. doi: 10.1016/j.yexcr.2011.07.016. Epub 2011 Aug 9.
64. Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats. Liu P, etal., Neurosci Lett. 2013 May 24;543:115-20. doi: 10.1016/j.neulet.2013.02.065. Epub 2013 Apr 3.
65. Genetic variation in insulin-like growth factors and brain tumor risk. Lonn S, etal., Neuro Oncol. 2008 Aug;10(4):553-9. Epub 2008 Jun 18.
66. Insulin-like growth factor-I activation of Akt survival cascade in neuronal cells requires the presence of its cognate receptor in caveolae. Lu X, etal., Exp Cell Res. 2008 Jan 15;314(2):342-51. Epub 2007 Oct 26.
67. Expression of GH receptor, IGF-I receptor and IGF-I mRNA in the kidney and liver of rats recovering from unilateral renal ischemia. Matejka GL Growth Horm IGF Res. 1998 Feb;8(1):77-82.
68. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
69. Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1 beta (IL-1 beta), and IL-6 mRNA expression in osteoarthritic and normal human cartilage. Middleton J, etal., J Histochem Cytochem. 1996 Feb;44(2):133-41.
70. Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer. Min Y, etal., Cancer Res. 2003 Oct 1;63(19):6432-41.
71. TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells. Mincione G, etal., Exp Cell Res. 2003 Jul 15;287(2):411-23.
72. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .
73. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
74. Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistance. Nguyen VA, etal., Nutrients. 2012 Aug;4(8):1042-57. Epub 2012 Aug 17.
75. Fetal programming of gene expression in growth-restricted rats depends on the cause of low birth weight. Nüsken KD, etal., Endocrinology. 2011 Apr;152(4):1327-35. doi: 10.1210/en.2010-1116. Epub 2011 Jan 25.
76. Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo. Ofer P, etal., Mol Endocrinol. 2015 Dec;29(12):1694-707. doi: 10.1210/me.2015-1073. Epub 2015 Oct 9.
77. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
78. Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas. Ouban A, etal., Hum Pathol. 2003 Aug;34(8):803-8.
79. Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605. Pappano WN, etal., BMC Cancer. 2009 Sep 4;9:314.
80. Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death. Pehar M, etal., Aging Cell. 2010 Apr;9(2):174-90.
81. Chromium improves protein deposition through regulating the mRNA levels of IGF-1, IGF-1R, and Ub in rat skeletal muscle cells. Peng Z, etal., Biol Trace Elem Res. 2010 Nov;137(2):226-34. doi: 10.1007/s12011-009-8579-3. Epub 2009 Dec 15.
82. Abnormalities of insulin-like growth factor-I signaling and impaired cell proliferation in osteoblasts from subjects with osteoporosis. Perrini S, etal., Endocrinology. 2008 Mar;149(3):1302-13. Epub 2007 Dec 13.
83. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
84. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
85. Uptake of circulating insulin-like growth factors (IGFs) into cerebrospinal fluid appears to be independent of the IGF receptors as well as IGF-binding proteins. Pulford BE and Ishii DN, Endocrinology 2001 Jan;142(1):213-20.
86. The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling. Razuvaev A, etal., J Vasc Surg. 2007 Jul;46(1):108-15.
87. Impairment of myocyte contractility following coronary artery narrowing is associated with activation of the myocyte IGF1 autocrine system, enhanced expression of late growth related genes, DNA synthesis, and myocyte nuclear mitotic division in rats. Reiss K, etal., Exp Cell Res. 1993 Aug;207(2):348-60.
88. Reduced contractile response to insulin and IGF-I in ventricular myocytes from genetically obese Zucker rats. Ren J, etal., Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1708-14.
89. GOA pipeline RGD automated data pipeline
90. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
91. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
92. Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. Rotem-Yehudar R, etal., J Biol Chem. 2001 Aug 31;276(35):33054-60. Epub 2001 Jun 21.
93. Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle. Saito T, etal., Zoolog Sci 2003 Apr;20(4):441-7.
94. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. Schubert M, etal., J Neurosci 2003 Aug 6;23(18):7084-92.
95. Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. Shen L, etal., Toxicol Appl Pharmacol. 2014 Jan 15;274(2):263-73. doi: 10.1016/j.taap.2013.11.009. Epub 2013 Nov 22.
96. Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor. Sherajee SJ, etal., Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):257-63. doi: 10.1161/ATVBAHA.111.240697. Epub 2011 Dec 15.
97. Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis. Sipos F, etal., Scand J Gastroenterol. 2008 Mar;43(3):289-98.
98. IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity. Sosa L, etal., Nat Neurosci. 2006 Aug;9(8):993-5. Epub 2006 Jul 16.
99. Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain. Soscia SJ, etal., Cell Mol Life Sci. 2006 Sep;63(17):2039-56.
100. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. Sunters A, etal., J Biol Chem. 2010 Mar 19;285(12):8743-58. doi: 10.1074/jbc.M109.027086. Epub 2009 Dec 30.
101. Axonal regeneration induced by repetitive electrical stimulation of crushed optic nerve in adult rats. Tagami Y, etal., Jpn J Ophthalmol. 2009 May;53(3):257-66. Epub 2009 May 31.
102. Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Tanno B, etal., Clin Cancer Res. 2006 Nov 15;12(22):6772-80.
103. Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats. Todd BJ, etal., Biol Reprod. 2007 Sep;77(3):492-503. Epub 2007 Jun 13.
104. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. Tong M, etal., J Alzheimers Dis. 2009;16(3):585-99.
105. Insulin-like growth factor-I receptor and estrogen receptor crosstalk mediates hormone-induced neurite outgrowth in PC12 cells. Topalli I and Etgen AM, Brain Res 2004 Dec 24;1030(1):116-24.
106. Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer. Ueda S, etal., Mod Pathol. 2006 Jun;19(6):788-96.
107. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Ueki K, etal., Nat Genet. 2006 May;38(5):583-8. Epub 2006 Apr 23.
108. Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1. Vargas MR, etal., J Neurosci Res. 2008 Dec;86(16):3515-25. doi: 10.1002/jnr.21797.
109. Localization of insulin-like growth factor-1 receptor in human normal and osteoarthritic cartilage in relation to proteoglycan synthesis and content. Verschure PJ, etal., Br J Rheumatol. 1996 Nov;35(11):1044-55.
110. Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity. Viana-Huete V, etal., Endocrinology. 2016 Apr;157(4):1495-511. doi: 10.1210/en.2015-1623. Epub 2016 Feb 24.
111. RGS-GAIP-interacting protein controls breast cancer progression. Wang L, etal., Mol Cancer Res. 2010 Dec;8(12):1591-600. doi: 10.1158/1541-7786.MCR-10-0209. Epub 2010 Oct 27.
112. Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin. Wang R, etal., Mol Ther Nucleic Acids. 2018 Dec 7;13:44-54. doi: 10.1016/j.omtn.2018.08.015. Epub 2018 Aug 24.
113. MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Wang XH, etal., Clin Exp Pharmacol Physiol. 2009 Feb;36(2):181-8. Epub 2008 Sep 26.
114. Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor and its intervention by interleukin-10 in experimental hepatic fibrosis. Wang XZ, etal., World J Gastroenterol. 2003 Jun;9(6):1287-91.
115. Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat. Wang Z, etal., Endocrinology. 2008 Mar;149(3):1366-76. doi: 10.1210/en.2007-1410. Epub 2007 Dec 13.
116. Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product. Werner H, etal., Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5828-32.
117. Interaction between the renin-angiotensin system and insulin-like growth factor I in aorto-caval fistula-induced cardiac hypertrophy in rats. Wåhlander H, etal., Acta Physiol Scand. 1999 Feb;165(2):143-54.
118. Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma. Xie HY, etal., Tissue Antigens. 2014 Sep;84(3):264-70. doi: 10.1111/tan.12360. Epub 2014 Apr 23.
119. Nicotine-induced over-exposure to maternal glucocorticoid and activated glucocorticoid metabolism causes hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic alterations in fetal rats. Xu D, etal., Toxicol Lett. 2012 Mar 25;209(3):282-90. doi: 10.1016/j.toxlet.2012.01.006. Epub 2012 Jan 14.
120. Insulin-Like growth factor 1 related pathways and high-fat diet promotion of transgenic adenocarcinoma mouse prostate (TRAMP) cancer progression. Xu H, etal., Actas Urol Esp. 2015 Apr;39(3):161-8. doi: 10.1016/j.acuro.2014.05.014. Epub 2014 Oct 28.
121. Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway. Xu L, etal., Br J Pharmacol. 2009 Oct;158(3):738-48. Epub 2009 Aug 24.
122. [Studies on insulin-like growth factor I receptor in fetal rats with intrauterine growth retardation]. Yang F, etal., Hua Xi Yi Ke Da Xue Xue Bao. 2001 Sep;32(3):402-4.
123. Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer. Yang X, etal., Pathol Oncol Res. 2017 Jan;23(1):73-77. doi: 10.1007/s12253-016-0086-1. Epub 2016 Jul 13.
124. Differential expression of IGF1, IGFR1 and IGFBP3 in mandibular condylar cartilage between male and female rats applied with malocclusion. Yu S, etal., J Oral Rehabil. 2012 Oct;39(10):727-36. doi: 10.1111/j.1365-2842.2012.02332.x. Epub 2012 Jul 3.
125. High levels of glucose induce apoptosis in cardiomyocyte via epigenetic regulation of the insulin-like growth factor receptor. Yu XY, etal., Exp Cell Res. 2010 Oct 15;316(17):2903-9. doi: 10.1016/j.yexcr.2010.07.004. Epub 2010 Jul 13.
126. The effects of mesenchymal stem cells on c-kit up-regulation and cell-cycle re-entry of neonatal cardiomyocytes are mediated by activation of insulin-like growth factor 1 receptor. Yu XY, etal., Mol Cell Biochem. 2009 Jun 9.
127. miR-194 Promotes burn-induced hyperglycemia via attenuating IGF-IR expression. Yu Y, etal., Shock. 2014 Dec;42(6):578-84. doi: 10.1097/SHK.0000000000000258.
128. Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer. Yuen JS, etal., Mol Cancer Ther. 2009 Jun;8(6):1448-59. doi: 10.1158/1535-7163.MCT-09-0101. Epub 2009 Jun 9.
129. Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period. Zakaria R, etal., Acta Histochem. 2009;111(1):52-60. Epub 2008 Aug 3.
130. Immunohistochemical localisation of growth hormone (GH), GH receptor (GHR), insulin-like growth factor I (IGF-I) and type I IGF-I receptor, and gene expression of GH and GHR in rat pre-antral follicles. Zhao J, etal., Zygote 2002 Feb;10(1):85-94.
131. Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. Zhao WQ, etal., J Biol Chem. 2009 Jul 10;284(28):18742-53. doi: 10.1074/jbc.M109.011015. Epub 2009 Apr 30.
132. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. Zheng D, etal., Mol Carcinog. 2010 Feb;49(2):200-9.
133. Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons. Zheng WH and Quirion R, J Biol Chem. 2009 Jan 9;284(2):855-61. Epub 2008 Nov 3.
Additional References at PubMed
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Genomics

Comparative Map Data
Igf1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81130,959,787 - 131,248,664 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1130,959,997 - 131,248,664 (+)EnsemblGRCr8
mRatBN7.21121,549,831 - 121,838,548 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1121,550,743 - 121,831,777 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1129,548,259 - 129,834,935 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01136,718,334 - 137,005,027 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01129,519,288 - 129,805,989 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01128,924,921 - 129,213,816 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1128,924,966 - 129,206,516 (+)Ensemblrn6Rnor6.0
Rnor_5.01129,985,761 - 130,272,589 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41122,704,976 - 122,990,007 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1113,751,636 - 114,029,884 (+)NCBICelera
RGSC_v3.11122,783,318 - 123,068,350 (+)NCBI
Cytogenetic Map1q22NCBI
IGF1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381598,648,539 - 98,964,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1598,648,539 - 98,964,530 (+)Ensemblhg38GRCh38
GRCh371599,191,768 - 99,507,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361597,010,284 - 97,325,282 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341597,010,287 - 97,319,034NCBI
Celera1575,609,678 - 75,924,704 (+)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1575,320,348 - 75,635,223 (+)NCBIHuRef
CHM1_11599,034,201 - 99,349,171 (+)NCBICHM1_1
T2T-CHM13v2.01596,412,912 - 96,728,919 (+)NCBIT2T-CHM13v2.0
Igf1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39767,601,486 - 67,883,416 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl767,602,575 - 67,883,416 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38767,952,257 - 68,233,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl767,952,827 - 68,233,668 (+)Ensemblmm10GRCm38
MGSCv37775,097,143 - 75,378,553 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36767,826,372 - 68,100,293 (+)NCBIMGSCv36mm8
Celera765,407,649 - 65,690,413 (+)NCBICelera
Cytogenetic Map7CNCBI
cM Map737.27NCBI
Igf1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541626,102,628 - 26,382,666 (-)Ensembl
ChiLan1.0NW_00495541626,101,090 - 26,382,660 (-)NCBIChiLan1.0ChiLan1.0
IGF1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21688,195,825 - 88,510,506 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11591,892,588 - 92,207,137 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01577,332,926 - 77,648,474 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11596,576,930 - 96,832,974 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1596,535,164 - 96,832,974 (+)EnsemblpanPan2panpan1.1
IGF1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1341,795,337 - 42,096,255 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl341,794,623 - 42,090,387 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha344,494,039 - 44,797,005 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0342,203,106 - 42,506,274 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl342,203,091 - 42,501,470 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1341,727,974 - 42,030,799 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0341,958,900 - 42,261,698 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0342,179,556 - 42,481,580 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Igf1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640141,474,253 - 141,770,018 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364834,564,512 - 4,852,925 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364834,563,995 - 4,860,231 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1137,387,825 - 137,691,058 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11137,383,623 - 137,691,038 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21153,523,944 - 153,853,776 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q17-q21NCBI
IGF1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12917,212,206 - 17,534,036 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2917,459,404 - 17,526,930 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605929,058,966 - 29,370,219 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igf1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247685,396,156 - 5,681,809 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247685,396,027 - 5,688,435 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Igf1r
2282 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir378rno-miR-378a-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI22367207

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:36
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000019267
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611131244255Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
D1Hmgc5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,550,195 - 121,550,322 (+)MAPPERmRatBN7.2
Rnor_6.01128,924,376 - 128,924,502NCBIRnor6.0
Rnor_5.01129,985,259 - 129,985,385UniSTSRnor5.0
RGSC_v3.41122,704,429 - 122,704,555UniSTSRGSC3.4
Celera1113,751,091 - 113,751,217UniSTS
RH 3.4 Map11447.71UniSTS
RH 3.4 Map11447.71RGD
Cytogenetic Map1q22UniSTS
RH143949  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,610,901 - 121,611,031 (+)MAPPERmRatBN7.2
Rnor_6.01128,985,452 - 128,985,581NCBIRnor6.0
Rnor_5.01130,045,545 - 130,045,674UniSTSRnor5.0
RGSC_v3.41122,765,365 - 122,765,494UniSTSRGSC3.4
Celera1113,808,998 - 113,809,127UniSTS
RH 3.4 Map11447.51UniSTS
Cytogenetic Map1q22UniSTS
D1Bda23  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81131,241,505 - 131,241,864 (+)Marker Load Pipeline
mRatBN7.21121,831,389 - 121,831,748 (+)MAPPERmRatBN7.2
Rnor_6.01129,206,658 - 129,207,016NCBIRnor6.0
Rnor_5.01130,265,431 - 130,265,789UniSTSRnor5.0
RGSC_v3.41122,989,611 - 122,989,969UniSTSRGSC3.4
Celera1114,029,488 - 114,029,846UniSTS
Cytogenetic Map1q22UniSTS
BE111364  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,617,712 - 121,617,863 (+)MAPPERmRatBN7.2
Rnor_6.01128,992,243 - 128,992,393NCBIRnor6.0
Rnor_5.01130,052,395 - 130,052,545UniSTSRnor5.0
RGSC_v3.41122,772,244 - 122,772,394UniSTSRGSC3.4
Celera1113,815,808 - 113,815,958UniSTS
RH 3.4 Map11447.01UniSTS
Cytogenetic Map1q22UniSTS
RH135226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,678,712 - 121,678,905 (+)MAPPERmRatBN7.2
Rnor_6.01129,053,503 - 129,053,695NCBIRnor6.0
Rnor_5.01130,113,131 - 130,113,323UniSTSRnor5.0
RGSC_v3.41122,832,903 - 122,833,095UniSTSRGSC3.4
Celera1113,877,067 - 113,877,259UniSTS
RH 3.4 Map11447.21UniSTS
Cytogenetic Map1q22UniSTS
BE119057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,585,764 - 121,585,920 (+)MAPPERmRatBN7.2
Rnor_6.01128,960,536 - 128,960,691NCBIRnor6.0
Rnor_5.01130,020,629 - 130,020,784UniSTSRnor5.0
RGSC_v3.41122,740,218 - 122,740,373UniSTSRGSC3.4
Celera1113,786,256 - 113,786,411UniSTS
RH 3.4 Map11450.09UniSTS
Cytogenetic Map1q22UniSTS
BM384925  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,668,713 - 121,668,915 (+)MAPPERmRatBN7.2
Rnor_6.01129,043,490 - 129,043,691NCBIRnor6.0
Rnor_5.01130,103,642 - 130,103,843UniSTSRnor5.0
RGSC_v3.41122,823,240 - 122,823,441UniSTSRGSC3.4
Celera1113,866,780 - 113,866,981UniSTS
RH 3.4 Map11445.91UniSTS
Cytogenetic Map1q22UniSTS
Igf1r  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,767,509 - 121,767,639 (+)MAPPERmRatBN7.2
Rnor_6.01129,142,678 - 129,142,807NCBIRnor6.0
Rnor_5.01130,201,338 - 130,201,467UniSTSRnor5.0
RGSC_v3.41122,924,226 - 122,924,355UniSTSRGSC3.4
Celera1113,965,994 - 113,966,123UniSTS
Cytogenetic Map1q22UniSTS
GDB:187366  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,550,241 - 121,550,343 (+)MAPPERmRatBN7.2
Rnor_6.01128,924,422 - 128,924,523NCBIRnor6.0
Rnor_5.01129,985,305 - 129,985,406UniSTSRnor5.0
RGSC_v3.41122,704,475 - 122,704,576UniSTSRGSC3.4
Celera1113,751,137 - 113,751,238UniSTS
Cytogenetic Map1q22UniSTS
TAMU_PKR0001  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,787,521 - 121,787,702 (+)MAPPERmRatBN7.2
Rnor_6.01129,162,783 - 129,162,963NCBIRnor6.0
Rnor_5.01130,221,443 - 130,221,623UniSTSRnor5.0
RGSC_v3.41122,944,321 - 122,944,501UniSTSRGSC3.4
Celera1113,985,952 - 113,986,132UniSTS
Cytogenetic Map1q22UniSTS
IGF1R  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,787,521 - 121,787,702 (+)MAPPERmRatBN7.2
Rnor_6.01129,162,783 - 129,162,963NCBIRnor6.0
Rnor_5.01130,221,443 - 130,221,623UniSTSRnor5.0
RGSC_v3.41122,944,321 - 122,944,501UniSTSRGSC3.4
Celera1113,985,952 - 113,986,132UniSTS
Cytogenetic Map1q22UniSTS
Igf1r  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21121,603,353 - 121,603,746 (+)MAPPERmRatBN7.2
Rnor_6.01128,978,121 - 128,978,513NCBIRnor6.0
Rnor_5.01130,038,214 - 130,038,606UniSTSRnor5.0
RGSC_v3.41122,757,817 - 122,758,209UniSTSRGSC3.4
Celera1113,801,551 - 113,801,943UniSTS
Cytogenetic Map1q22UniSTS


Related Rat Strains
The following Strains have been annotated to Igf1r
SHRSP.WKY-(Igf1r-D1Rat36)/IzmTkyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019267   ⟹   ENSRNOP00000019267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1131,010,204 - 131,248,664 (+)Ensembl
mRatBN7.2 Ensembl1121,550,743 - 121,831,777 (+)Ensembl
Rnor_6.0 Ensembl1128,924,966 - 129,206,516 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096947   ⟹   ENSRNOP00000106862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1130,959,997 - 131,248,664 (+)Ensembl
RefSeq Acc Id: NM_001414181   ⟹   NP_001401110
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,959,997 - 131,248,664 (+)NCBI
mRatBN7.21121,549,831 - 121,838,548 (+)NCBI
RefSeq Acc Id: NM_052807   ⟹   NP_434694
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,959,997 - 131,248,664 (+)NCBI
mRatBN7.21121,549,831 - 121,838,548 (+)NCBI
Rnor_6.01128,924,921 - 129,207,054 (+)NCBI
Rnor_5.01129,985,761 - 130,272,589 (+)NCBI
RGSC_v3.41122,704,976 - 122,990,007 (+)RGD
Celera1113,751,636 - 114,029,884 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759500   ⟹   XP_008757722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,959,792 - 131,248,664 (+)NCBI
mRatBN7.21121,549,842 - 121,838,545 (+)NCBI
Rnor_6.01128,924,923 - 129,213,816 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102217   ⟹   XP_038958145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,959,790 - 131,248,664 (+)NCBI
mRatBN7.21121,549,841 - 121,838,545 (+)NCBI
RefSeq Acc Id: XM_039102225   ⟹   XP_038958153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,959,787 - 131,212,975 (+)NCBI
mRatBN7.21121,549,839 - 121,801,744 (+)NCBI
RefSeq Acc Id: NP_434694   ⟸   NM_052807
- Peptide Label: isoform 2 precursor
- UniProtKB: P24062 (UniProtKB/Swiss-Prot),   A0A140TAB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757722   ⟸   XM_008759500
- Peptide Label: isoform X1
- UniProtKB: A0A140TAB8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019267   ⟸   ENSRNOT00000019267
RefSeq Acc Id: XP_038958153   ⟸   XM_039102225
- Peptide Label: isoform X3
- UniProtKB: A6JBU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958145   ⟸   XM_039102217
- Peptide Label: isoform X2
- UniProtKB: A0A140TAB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001401110   ⟸   NM_001414181
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A140TAB8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106862   ⟸   ENSRNOT00000096947
Protein Domains
Fibronectin type-III   Protein kinase   Receptor L-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24062-F1-model_v2 AlphaFold P24062 1-1370 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690112
Promoter ID:EPDNEW_R635
Type:single initiation site
Name:Igf1r_1
Description:insulin-like growth factor 1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01128,924,935 - 128,924,995EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2869 AgrOrtholog
BioCyc Gene G2FUF-58972 BioCyc
Ensembl Genes ENSRNOG00000014187 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019267 ENTREZGENE
  ENSRNOT00000019267.7 UniProtKB/Swiss-Prot
  ENSRNOT00000096947 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.80.20.20 UniProtKB/Swiss-Prot
  Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Furin-like_Cys-rich_dom UniProtKB/Swiss-Prot
  Furin_repeat UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Rcpt_L-dom UniProtKB/Swiss-Prot
  Rcpt_L-dom_sf UniProtKB/Swiss-Prot
  RTK UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_insulin-like_rcpt UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot
KEGG Report rno:25718 UniProtKB/Swiss-Prot
NCBI Gene 25718 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
Pfam Furin-like UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  Recep_L_domain UniProtKB/Swiss-Prot
PhenoGen Igf1r PhenoGen
PIRSF Insulin_receptor UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE FN3 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014187 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
  SM00261 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A140TAB8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L974_RAT UniProtKB/TrEMBL
  A6JBU4_RAT UniProtKB/TrEMBL
  A6JBU5 ENTREZGENE, UniProtKB/TrEMBL
  A6JBU6_RAT UniProtKB/TrEMBL
  IGF1R_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-06 Igf1r  insulin-like growth factor 1 receptor  Igf1r  insulin-like growth factor I receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Igf1r  insulin-like growth factor I receptor  Igf1r  insulin-like growth factor 1 receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Igf1r  insulin-like growth factor 1 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease overexpressed in most malignant tissues 61526
gene_disease overexpressed in most malignant tissues 70266
gene_process plays a role in transformation events 61526
gene_process plays a role in transformation events 70266
gene_process functions as an anti-apoptotic agent in malignant tissues 61526
gene_process functions as an anti-apoptotic agent in malignant tissues 70266
gene_regulation tyrosine phosphorylated by epidermal growth factor (EGF) 727470