GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Igf1r | increases expression | EXP | | 6480464 | CTD | Hexachlorobenzene results in increased expression of IGF1R protein | PMID:16237195 | Igf1r | multiple interactions | EXP | | 6480464 | CTD | Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein] | PMID:16237195 | Igf1r | increases expression | ISO | IGF1R (Homo sapiens) | 6480464 | CTD | Hexachlorobenzene results in increased expression of IGF1R protein | PMID:19879930 | Igf1r | multiple interactions | ISO | IGF1R (Homo sapiens) | 6480464 | CTD | [Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased phosphorylation of IGF1R protein; Fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of IGF1R protein] | PMID:19879930 PMID:33571556 | |
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