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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Acc ID: CHEBI:75251
Term: picropodophyllotoxin
Definition: An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.
Chemical ID: MESH:C415032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rdecreases activityISOIGF1R (Homo sapiens)6480464CTDpicropodophyllin results in decreased activity of IGF1R proteinPMID:16166596
Igf1rmultiple interactionsISOIgf1r (Mus musculus)6480464CTDpicropodophyllin binds to and results in decreased activity of IGF1R proteinPMID:21371294
Igf1rmultiple interactionsISOIGF1R (Homo sapiens)6480464CTD[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; [picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]PMID:23673518
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