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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1raffects expressionEXP 6480464CTDNicotine affects the expression of IGF1R mRNAPMID:31972234
Igf1rdecreases expressionEXP 6480464CTDNicotine results in decreased expression of IGF1R mRNA; Nicotine results in decreased expression of IGF1R proteinPMID:20960268 PMID:22265867
Igf1rincreases expressionEXP 6480464CTDNicotine results in increased expression of IGF1R mRNAPMID:20426880
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