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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rincreases expressionEXP 6480464CTDresveratrol results in increased expression of IGF1R mRNAPMID:23848300
Igf1rmultiple interactionsEXP 6480464CTDResveratrol inhibits the reaction [bisphenol A results in decreased expression of IGF1R mRNA]PMID:37570835
Igf1rdecreases expressionISOIGF1R (Homo sapiens)6480464CTDresveratrol results in decreased expression of IGF1R mRNA; resveratrol results in decreased expression of IGF1R proteinPMID:18586690 PMID:20504360 PMID:23810794 PMID:25667456
Igf1rdecreases phosphorylationISOIGF1R (Homo sapiens)6480464CTDresveratrol results in decreased phosphorylation of IGF1R proteinPMID:26394120
Igf1rincreases expressionISOIgf1r (Mus musculus)6480464CTDresveratrol results in increased expression of IGF1R mRNA; resveratrol results in increased expression of IGF1R proteinPMID:17675339 PMID:23525482 PMID:24330398
Igf1rmultiple interactionsISOIgf1r (Mus musculus)6480464CTDresveratrol inhibits the reaction [IGF1 protein binds to and results in increased phosphorylation of and results in increased activity of IGF1R protein]PMID:24782617
Igf1rmultiple interactionsISOIGF1R (Homo sapiens)6480464CTDresveratrol inhibits the reaction [bisphenol A results in increased expression of IGF1R mRNA]; resveratrol inhibits the reaction [Estradiol results in increased expression of IGF1R mRNA]; resveratrol inhibits the reaction [IGF1 protein binds to and results in increased phosphorylation of and results in increased activity of IGF1R protein]; resveratrol inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]PMID:18586690 PMID:23810794 PMID:24782617
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