RGD Reference Report - Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period. - Rat Genome Database

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Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period.

Authors: Zakaria, R  Rajikin, MH  Yaacob, NS  Nor, NM 
Citation: Zakaria R, etal., Acta Histochem. 2009;111(1):52-60. Epub 2008 Aug 3.
RGD ID: 2311502
Pubmed: PMID:18676006   (View Abstract at PubMed)
DOI: DOI:10.1016/j.acthis.2008.04.002   (Journal Full-text)

The aim of the present study was to analyze the immunolocalization of insulin-like growth factor (IGF)-1 and IGF-2 and their receptors in the oviduct and uterus of control and diabetic mice. Sexually mature female ICR mice aged 6-8 weeks were rendered diabetic by streptozotocin (200 mg/kg, administered intraperitoneally). Oviductal and uterine tissues were obtained from the superovulated control and diabetic mice at 48, 72 and 96 h post-human chorionic gonadotropin (hCG) treatment. Localization of IGF-1, IGF-2, IGF-1R and IGF-2R was determined by immunohistochemistry and a semi-quantitative scoring of immunolabelling was performed using a standardized 5-point system. The immunohistochemical scorings for both IGF-1 and IGF-1R were significantly decreased in the oviducts of diabetic mice at 96 h post-hCG treatment. The scores for IGF-2 were significantly increased in the oviducts of diabetic mice at 48 and 72 h post-hCG treatment, and for IGF-2R at 72 h post-hCG treatment. However, there was no significant difference in the scores of IGFs and their receptors in the uterus of control and diabetic mice. In conclusion, the oviductal immunolabelling for IGFs and their receptors was significantly altered by maternal diabetes, which may be of importance in the pathogenesis of preimplantation diabetic embryopathy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOIgf1 (Mus musculus)2311502; 2311502protein:decreased expression:oviductRGD 
Experimental Diabetes Mellitus  ISOIgf1r (Mus musculus)2311502; 2311502protein:decreased expression:oviductRGD 
Experimental Diabetes Mellitus  ISOIgf2 (Mus musculus)2311502; 2311502protein:increased expression:oviductRGD 
Experimental Diabetes Mellitus  ISOIgf2r (Mus musculus)2311502; 2311502protein:increased expression:oviductRGD 
Experimental Diabetes Mellitus  IEP 2311502; 2311502protein:decreased expression:oviductRGD 
Experimental Diabetes Mellitus  IEP 2311502; 2311502protein:increased expression:oviductRGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1  (insulin-like growth factor 1)
Igf1r  (insulin-like growth factor 1 receptor)
Igf2  (insulin-like growth factor 2)
Igf2r  (insulin-like growth factor 2 receptor)

Genes (Mus musculus)
Igf1  (insulin-like growth factor 1)
Igf1r  (insulin-like growth factor I receptor)
Igf2  (insulin-like growth factor 2)
Igf2r  (insulin-like growth factor 2 receptor)

Genes (Homo sapiens)
IGF1  (insulin like growth factor 1)
IGF1R  (insulin like growth factor 1 receptor)
IGF2  (insulin like growth factor 2)
IGF2R  (insulin like growth factor 2 receptor)


Additional Information